GPR63

GPR63
Identifiers
Aliases	GPR63, PSP24(beta), PSP24B, G protein-coupled receptor 63
External IDs	MGI: 2135884 HomoloGene: 12759 GeneCards: GPR63
Targeted by Drug
sphingosine 1-phosphate
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • receptor complex • membrane • nucleus • cytosol • plasma membrane Biological process • G-protein coupled receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81491	81006
Ensembl	ENSG00000112218	ENSMUSG00000040372
UniProt	Q9BZJ6	Q9EQQ3
RefSeq (mRNA)	NM_001143957 NM_030784	NM_030733
RefSeq (protein)	NP_001137429 NP_110411	NP_109658.2
Location (UCSC)	Chr 6: 96.79 – 96.84 Mb	Chr 4: 24.97 – 25.01 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]

Further reading

• Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574. 
• Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems.". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575. 
• Lee DK, George SR, Cheng R, et al. (2001). "Identification of four novel human G protein-coupled receptors expressed in the brain.". Brain Res. Mol. Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Niedernberg A, Tunaru S, Blaukat A, et al. (2004). "Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63". Cell. Signal. 15 (4): 435–46. doi:10.1016/S0898-6568(02)00119-5. PMID 12618218. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.