The duo reigns for the second time in three weeks. Meanwhile, The Chainsmokers move up to No. 2, and Bon Iver & Solange debut in the top 10.

Twenty One Pilots are back atop the Billboard Artist 100 chart (dated Oct. 22), crowning the ranking for the second time in three weeks as they rise 2-1. The Artist 100 measures artist activity across Billboard's most influential charts, including the Billboard Hot 100, Top Album Sales and the Social 50. The Artist 100 blends data measuring album and track sales, radio airplay, streaming and social media fan interaction to provide a weekly multi-dimensional ranking of artist popularity.

The duo's return to No. 1 comes two weeks after the pair set the record for longest climb to No. 1 (75 weeks), a feat that was then eclipsed by Shawn Mendes, who reigned for the first time in his 86th week on the chart the following week. (The chart began on July 19, 2014.)

Of Twenty One Pilots' Artist 100 chart points, the largest percentage is from album sales (45 percent), followed by radio airplay (27 percent), as their current single "Heathens" pushes 5-2 on Radio Songs with 12 million in audience, up 12 percent, according to Nielsen Music.

Rounding out the Artist 100's top five, The Chainsmokers leap 4-2, the duo's highest peak yet as its hit "Closer," featuring Halsey, continues to reign on the Billboard Hot 100; Drake holds at No. 3; The Weeknd rises 6-4; and Bon Iver debuts at No. 5, as the folk-rock act's third studio album, 22, A Million, debuts on the Billboard 200 at No. 2 with 71,000 equivalent album units, 58,000 of which are pure album sales (which contribute 89 percent of Bon Iver's Artist 100 chart points).

Just beyond the Artist 100's top five, Mendes, the previous No. 1, falls to No, 6, while Solange, whose new album A Seat at the Table debuts at No. 1 on the Billboard 200, marking her first chart-topper, debuts on the Artist 100 at No. 8. Like Bon Iver, the vast majority of her chart points (84 percent) stem from album sales.

Check out this week's entire Artist 100 here.