Brian Cox

Brian Cox may refer to:

See also

Cox (surname)

The surname Cox is of English or Welsh origin, and may have originated independently in several places in Great Britain, with the variations arriving at a standard spelling only later. There are also two native Irish surnames which were anglicised into Cox.

An early record of the surname dates from 1556 with the marriage of Alicea Cox at St. Martin in the Fields, Westminster, London. Cox is the 69th-most common surname in the United Kingdom.

Origin

One possibility of the origin is that it is a version of the Old English cocc which means "the little", and was sometimes put after the name of a leader or chieftain as a term of endearment. Surnames such as Wilcox, Willcocks and Willcox are examples of this practice: all are composed of the name William and the archaic word cocc, coming together to mean "little William". The suggestion is that only the element -cox may have endured as a surname for some families.

Another opinion is that the name is derived from the Old English cock, which means a "heap" or "mound", and was a topographic name for a man living near any heap, hill or other bundle. Names like Haycock or Haycox come from such practice, meaning from "the hay mounds" or "the hay fields". Again, the element -cox may have only been carried on in some families.

Cytochrome c oxidase subunit II

Cytochrome c oxidase subunit 2, also known as cytochrome c oxidase polypeptide II, is a protein that in humans is encoded by the MT-CO2 gene.

Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase.

Structure

Cytochrome c oxidase (EC 1.9.3.1) is an oligomeric enzymatic complex which is a component of the respiratory chain and is involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. The enzyme complex consists of 3-4 subunits (prokaryotes) to up to 13 polypeptides (mammals). In Leigh's disease, there may be an abnormality or deficiency of cytochrome oxidase.

Function

Subunit 2 (COII) transfers the electrons from cytochrome c to the catalytic subunit 1. It contains two adjacent transmembrane regions in its N-terminus and the major part of the protein is exposed to the periplasmic or to the mitochondrial intermembrane space, respectively. COII provides the substrate-binding site and contains a copper centre called Cu(A) (see IPR001505), probably the primary acceptor in cytochrome c oxidase. An exception is the corresponding subunit of the cbb3-type oxidase which lacks the copper A redox-centre. Several bacterial COII have a C-terminal extension that contains a covalently bound haem c.

PTGS1

Cyclooxygenase-1 (COX-1), also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1, is an enzyme that in humans is encoded by the PTGS1 gene.

History

Cyclooxygenase (COX) is the central enzyme in the biosynthetic pathway to prostaglandins from arachidonic acid. This protein was purified more than 20 years ago and cloned in 1988.

Gene and isozymes

There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described.

Professor (1972 film)

Professor is a 1972 Indian Malayalam film, directed and produced by P. Subramaniam . The film stars Sharada, Gemini Ganesan, Thikkurissi Sukumaran Nair and Baby Rajashree in lead roles. The film had musical score by G. Devarajan.

Cast

Soundtrack

The music was composed by G. Devarajan and lyrics was written by Vayalar Ramavarma.

References

External links

Professor (disambiguation)

A professor is a senior teacher, lecturer and researcher, usually in a college or university.

Professor may also refer to:

Entertainment

Fictional characters

Specific characters

Professor (highest academic rank)

Professor (informally also known as full professor) is the highest academic rank at universities and other institutions of higher education in parts of the world. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences; a teacher of the highest rank.

Description

Commonwealth and European usage

In most Commonwealth nations (such as the United Kingdom, Australia, New Zealand, South Africa, English-speaking Caribbean) and northern Europe, professor is the title of the most senior academics at a university, typically a department chair, or an awarded chair specifically bestowed recognizing an individual at a university or similar institution. A professor is a highly accomplished and recognized academic, and the title is in most cases awarded only after decades of scholarly work to senior academics.

North American usage

The word professor is also used in other, lower titles such as Assistant Professor and Associate Professor, particularly in United States and Canada. Full Professor is the North American equivalent of Professor in other countries and uniquely signifies that the academic has been awarded tenure.