Toxicity

Toxicity is the degree to which a substance can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). By extension, the word may be metaphorically used to describe toxic effects on larger and more complex groups, such as the family unit or society at large.

A central concept of toxicology is that effects are dose-dependent; even water can lead to water intoxication when taken in too high a dose, whereas for even a very toxic substance such as snake venom there is a dose below which there is no detectable toxic effect. Toxicity is species-specific, making cross-species analysis problematic. Newer paradigms and metrics are evolving to bypass animal testing, while maintaining the concept of toxicity endpoints.

Types of toxicity

There are generally three types of toxic entities; chemical, biological, and physical:

System of a Down

System of a Down, often shortened to SOAD or System, is a four-piece Armenian-American rock band formed in 1994 in Glendale, California, in the United States. The band currently consists of Serj Tankian (lead vocals, keyboards), Daron Malakian (vocals, guitar), Shavo Odadjian (bass, backing vocals) and John Dolmayan (drums).

The band achieved commercial success with the release of five studio albums, three of which debuted at number one on the Billboard 200. System of a Down has been nominated for four Grammy Awards, and their song "B.Y.O.B." won the Best Hard Rock Performance of 2006. The group went on hiatus in August 2006 and reunited in November 2010, embarking on a tour for the following three years. System of a Down has sold over 40 million records worldwide.

History

Soil (1992–1994)

Serj Tankian and Daron Malakian attended Rose and Alex Pilibos Armenian School as children, although due to their eight-year age difference they did not meet until 1992 while working on separate projects at the same recording studio. They formed a band named Soil with Tankian on vocals and keyboards, Malakian on vocals and guitar, Dave Hakopyan (who later played in The Apex Theory/Mt. Helium) on bass and Domingo "Dingo" Laranio on drums. The band hired Shavo Odadjian (another Rose and Alex Pilibos alumnus) as manager, although he eventually joined Soil as rhythm guitarist. In 1994, after only one live show, and one jam session recording, Hakopyan and Laranio left the band, feeling that it was not going anywhere.