Catarrhini

ConPlan 8888 Planned Genocide

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• published: 02 Jul 2016
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Gene ID 8888 Official Symbol MCM3AP Full Name minichromosome maintenance complex component 3 associated protein provided by HGNC Primary source HGNC:HGNC:6946 See related Ensembl:ENSG00000160294 HPRD:04483; MIM:603294; Vega:OTTHUMG00000090630 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; HomoAlso known asGANP; SAC3; MAP80SummaryThe minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]