- published: 10 Aug 2016
- views: 4059933
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Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. The only thing we know for sure is that things will change irreversibly.
Support us on Patreon so we can make more videos (and get cool stuff in return): https://www.patreon.com/Kurzgesagt?ty=h
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Thanks to Volker Henn, James Gurney and (prefers anonymity) for help with this video!
THANKS A LOT TO OUR LOVELY PATRONS FOR SUPPORTING US:
Jeffrey Schneider, Konstantin Kaganovich, Tom Leiser, Archie Castillo, Russell Eishard, Ben Kershaw, Marius Stollen, Henry Bowman, Ben Johns, Bogdan Radu, Sam Toland, Pierre Thalamy, Christopher Morgan, Rocks Arent People, Ross Devereux, Pascal Michaud, Derek DuBreuil, Sofia Quintero, Robert Swiniarski, Merkt Kızılırmak, Michelle Rowley, Andy Dong, Saphir Patel, Harris Rotto, Thomas Huzij, Ryan James Burke, NTRX, Chaz Lewis, Amir Resali, The War on Stupid, John Pestana, Lucien Delbert, iaDRM, Jacob Edwards, Lauritz Klaus, Jason Hunt, Marcus : ), Taylor Lau, Rhett H Eisenberg, Mr.Z, Jeremy Dumet, Fatman13, Kasturi Raghavan, Kousora, Rich Sekmistrz, Mozart Peter, Gaby Germanos, Andreas Hertle, Alena Vlachova, Zdravko Šašek
SOURCES AND FURTHER READING:
The best book we read about the topic: GMO Sapiens
https://goo.gl/NxFmk8
(affiliate link, we get a cut if buy the book!)
– Good Overview by Wired:
http://bit.ly/1DuM4zq
–timeline of computer development:
http://bit.ly/1VtiJ0N
– Selective breeding:
http://bit.ly/29GaPVS
– DNA:
http://bit.ly/1rQs8Yk
– Radiation research:
http://bit.ly/2ad6wT1
– inserting DNA snippets into organisms:
http://bit.ly/2apyqbj
– First genetically modified animal:
http://bit.ly/2abkfYO
– First GM patent:
http://bit.ly/2a5cCox
– chemicals produced by GMOs:
http://bit.ly/29UvTbh
http://bit.ly/2abeHwU
http://bit.ly/2a86sBy
– Flavr Savr Tomato:
http://bit.ly/29YPVwN
– First Human Engineering:
http://bit.ly/29ZTfsf
– glowing fish:
http://bit.ly/29UwuJU
– CRISPR:
http://go.nature.com/24Nhykm
– HIV cut from cells and rats with CRISPR:
http://go.nature.com/1RwR1xI
http://ti.me/1TlADSi
– first human CRISPR trials fighting cancer:
http://go.nature.com/28PW40r
first human CRISPR trial approved by Chinese for August 2016:
http://go.nature.com/29RYNnK
– genetic diseases:
http://go.nature.com/2a8f7ny
– pregnancies with Down Syndrome terminated:
http://bit.ly/2acVyvg
( 1999 European study)
– CRISPR and aging:
http://bit.ly/2a3NYAV
http://bit.ly/SuomTy
http://go.nature.com/29WpDj1
http://ti.me/1R7Vus9
Help us caption & translate this video!
http://amara.org/v/USaR/
In this video Paul Andersen explains how the CRISPR/Cas immune system was identified in bacteria and how the CRISPR/Cas9 system was developed to edit genomes.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Music Attribution
Intro
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
Outro
Title: String Theory
Artist: Herman Jolly
http://sunsetvalley.bandcamp.com/track/string-theory
All of the images are licensed under creative commons and public domain licensing:
Adenosine. (2009). English: Artistic rendering of a T4 bacteriophage. The colours grey and orange do not signify anything, they are just used to illustrate structure. Created for Wikipedia. Retrieved from https://commons.wikimedia.org/wiki/File:PhageExterior.svg
E. coli Bacteria. (n.d.). Retrieved February 17, 2016, from https://www.flickr.com/photos/niaid/16598492368/
Fioretti, B. F. Hallbauer &. (2015). English: Director, Max Planck Institute for Infection Biology, Department of Regulation in Infection Biology. Visiting professor The Laboratory for Molecular Infection Medicine Sweden MIMS; http://www.mpiib-berlin.mpg.de/research/regulation_in_infection_biology. Retrieved from https://commons.wikimedia.org/wiki/File:Emmanuelle_Charpentier.jpg
Foresman, P. S. ([object HTMLTableCellElement]). English: Line art drawing of a chimera. Retrieved from https://commons.wikimedia.org/wiki/File:Chimera_(PSF).jpg
Magladem96. (2014). English: Picture of DNA Base Flipping. Retrieved from https://commons.wikimedia.org/wiki/File:Dna-base-flipping.svg
project, C. wiki. (2014). English: Crystal Structure of Cas9 bound to DNA based on the Anders et al 2014 Nature paper. Rendition was performed using UCSF’s chimera software. Retrieved from https://commons.wikimedia.org/wiki/File:Cas9_Anders_DNA_bound_structure.png
Providers, P. C. (1979). English: Photomicrograph of Streptococcus pyogenes bacteria, 900x Mag. A pus specimen, viewed using Pappenheim’s stain. Last century, infections by S. pyogenes claimed many lives especially since the organism was the most important cause of puerperal fever and scarlet fever. Streptococci. Retrieved from https://commons.wikimedia.org/wiki/File:Streptococcus_pyogenes.jpg
RRZEicons. (2010). English: zipper, open, close. Retrieved from https://commons.wikimedia.org/wiki/File:Zipper.svg
UC Berkeley. (n.d.). Gene editing with CRISPR-Cas9. Retrieved from https://www.youtube.com/watch?v=avM1Yg5oEu0
- published: 18 Feb 2016
- views: 179221
Any molecular biologist will tell you that genetic engineering is tricky. But up until recently we might be witnessing a new age in human development.
Hosted by: Michael Aranda
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Sources:
http://www.nature.com/news/crispr-gene-editing-is-just-the-beginning-1.19510
http://www.nature.com/news/crispr-the-disruptor-1.17673
http://www.nature.com/news/biologists-create-more-precise-molecular-scissors-for-genome-editing-1.18932
http://www.theatlantic.com/science/archive/2015/12/who-edits-the-gene-editors/418209/
http://www.nature.com/nbt/journal/v33/n9/abs/nbt.3290.html
http://www.theatlantic.com/science/archive/2016/01/the-most-exciting-uses-of-gene-editing-technology-involve-no-editing/422619/
http://www.nature.com/news/crispr-1.17547
https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr
http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/
http://www.yourgenome.org/facts/what-is-genetic-engineering
http://wyss.harvard.edu/staticfiles/newsroom/pressreleases/Gene%20drives%20FAQ%20FINAL.pdf
http://www.smithsonianmag.com/innovation/kill-all-mosquitos-180959069/?no-ist
https://www.jax.org/news-and-insights/jax-blog/2014/march/pros-and-cons-of-znfs-talens-and-crispr-cas
http://www.sciencemag.org/news/2016/06/human-crispr-trial-proposed
http://www.nature.com/news/chinese-scientists-to-pioneer-first-human-crispr-trial-1.20302?WT.mc_id=SFB_NNEWS_1508_RHBox
http://www.nature.com/news/uk-scientists-gain-licence-to-edit-genes-in-human-embryos-1.19270
http://www.nature.com/news/first-crispr-clinical-trial-gets-green-light-from-us-panel-1.20137
http://www.sciencemag.org/news/2016/04/crispr-debate-fueled-publication-second-human-embryo-editing-paper
http://www.sciencemag.org/news/2015/04/chinese-paper-embryo-engineering-splits-scientific-community
http://www.nature.com/news/gene-editing-method-tackles-hiv-in-first-clinical-test-1.14813
http://www.nature.com/nbt/journal/v34/n1/full/nbt.3439.html
Images:
https://sites.tufts.edu/crispr/crispr-background/
https://en.wikipedia.org/wiki/Anopheles#/media/File:Anopheles_stephensi.jpeg
- published: 31 Aug 2016
- views: 314548
Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, called CRISPR-Cas9. The tool allows scientists to make precise edits to DNA strands, which could lead to treatments for genetic diseases … but could also be used to create so-called "designer babies." Doudna reviews how CRISPR-Cas9 works — and asks the scientific community to pause and discuss the ethics of this new tool.
TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at http://www.ted.com/translate
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Like TED on Facebook: https://www.facebook.com/TED
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- published: 12 Nov 2015
- views: 230069
This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease. Feng Zhang, a leader in the development of this technology, is a faculty member at MIT, an investigator at the McGovern Institute for Brain Research, and a core member of the Broad Institute. Further information can be found on Prof. Zhang’s website at http://zlab.mit.edu .
Images and footage courtesy of Sputnik Animation, the Broad Institute of MIT and Harvard, Justin Knight and pond5.
- published: 05 Nov 2014
- views: 804766
Should we bring back the wooly mammoth? Or edit a human embryo? Or wipe out an entire species that we consider harmful? The genome-editing technology CRISPR has made extraordinary questions like these legitimate — but how does it work? Scientist and community lab advocate Ellen Jorgensen is on a mission to explain the myths and realities of CRISPR, hype-free, to the non-scientists among us.
TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at http://www.ted.com/translate
Follow TED news on Twitter: http://www.twitter.com/tednews
Like TED on Facebook: https://www.facebook.com/TED
Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector
- published: 24 Oct 2016
- views: 66322
What happens when you democratize science and give anyone the ability to edit DNA?
Subscribe to Reason TV for daily content like this: http://bit.ly/1Ocr2AL
See the full text at Reason.com: http://reason.com/reasontv/2016/06/17/biohacking-the-genome-for-just-140
MORE VIDEOS LIKE THIS:
3D Printing DNA and Hacking Life's Code:
https://youtu.be/PGyNyQ5IDUM?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd
WHAT OUT OF CONTROL BIOHACKING MEANS FOR THE FUTURE:
https://youtu.be/3kDLwbdjRfg?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd
---
"Are people dying and suffering needlessly because of all these committees and all these rules?" asks Josiah Zayner, a scientist, biohacker, and founder of the biotech company The Odin, which supplies low-cost CRISPR kits for the consumer market. "And what if people just say, 'F— you, I'm going to do it anyway'? And what if people start getting cured?"
CRISPR is a gene editing system that allows scientists to modify the DNA of organisms ranging from bacteria to plants and fungus to human beings. The Odin sells kits for the the modification of bacteria and yeast.
Reason TV visited Zayner in his garage lab to discuss the implications and ethics of bringing CRISPR to the masses, why he left a prestigious job in a NASA laboratory to start his own company, how regulation stifles scientific innovation, and why he believes that unregulated, decentralized experimentation will lead to the some the next great scientific breakthroughs.
Watch the full interview above, or click below for downloadable versions. Approximately 10 minutes. Produced by Zach Weissmueller. Camera by Alexis Garcia. Music by Kai Engel.
- published: 20 Jun 2016
- views: 31948
http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-birth-of-a-breakthrough-technology.html
Talk Overview:
Jennifer Doudna tells the story of how studying the way bacteria fight viral infection turned into a genomic engineering technology that has transformed molecular biology research. In 2013, Doudna and her colleagues developed the CRISPR-Cas9 gene expression system that, when introduced into animal cells, makes site-specific changes to intact genomes. CRISPR-Cas9 is more precise, more efficient, and less expensive than other genome editing tools and, as a result, has facilitated a wide range of studies that were previously unachievable.
Speaker Biography:
Jennifer Doudna is Professor of the Departments of Chemistry and of Molecular and Cell Biology at University of California, Berkeley, and an Investigator of the Howard Hughes Medical Institute. Early in her career, she studied the structure and mechanism of ribozymes (enzymatic RNA molecules) and RNA-protein complexes, such as the signal recognition particle. Now her research focuses on understanding how RNA molecules control gene expression in bacteria, through the CRISPR-Cas9 system, and eukaryotic cells, through RNA interference and microRNA-mediated translational control. For her outstanding scientific contributions, she was elected into the American Academy of Arts and Sciences in 2002 and the National Academy of Sciences in 2003, and was awarded the 2015 Breakthrough Prize in the Life Sciences.
- published: 23 Mar 2015
- views: 240761
Gene-editing tool CRISPR is everywhere in the news, but what is it and could it eliminate disease?
Sign Up For The TestTube Newsletter Here ►►►► http://bit.ly/1myXbFG
Should We Make Designer Babies? ►►►►http://bit.ly/1WbDT5s
Read More:
CRISPR: A game-changing genetic engineering technique
http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/
Have you heard? A revolution has seized the scientific community. Within only a few years, research labs worldwide have adopted a new technology that facilitates making specific changes in the DNA of humans, other animals, and plants.
CRISPR gene therapy: Scientists call for more public debate around breakthrough technique
http://www.independent.co.uk/news/science/crispr-gene-therapy-scientists-call-for-more-public-debate-around-breakthrough-technique-8927606.html
The technique, known as CRISPR, could revolutionise human gene therapy and genetic engineering because it allows scientists for the first time to make the finest changes to the DNA of the chromosomes with relative ease.
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- published: 15 Jan 2016
- views: 93036
CRISPR: It’s the powerful gene editing technology transforming biomedical research. Fast, cheap and easy to use, it allows scientists to rewrite the DNA in just about any organism—including humans—with tests on human embryos already underway. The technique’s potential to radically reshape everything from disease prevention to the future of human evolution has driven explosive progress and heated debate. Join the world’s CRISPR pioneers to learn about the enormous possibilities and ethical challenges as we stand on the threshold of a brave new world of manipulating life’s fundamental code.
Subscribe to our YouTube Channel for all the latest from WSF.
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Original Program Date: June 3 2016
MODERATOR: Richard Besser
PARTICIPANTS: George Church, Luke Dow, Josephine Johnston, Ben Matthews, Harry Ostrer, Noel Sauer
What is CRISPR? 00:05
Introduction by Richard Besser 3:58
Participant Introductions. 5:02
What is so powerful about CRISPR? 7:25
How is CRISPR is used? 13:00
How will CRISPR help eliminate Zika Virus? 20:45
Modifying 60 genes at once in a pig. 26:02
What are potential agricultural advantages from CRISPR? 28:44
If you have eaten CRISPR cells? 35:00
Using a gene drives to eliminate virus? 37:40
Creating an off switch for CRISPR 40:27
How is it ethical to not rid the world of malaria? 42:55
What is the difference between editing a germ line and editing a cancer cell? 48:27
Why would the first CRISPR baby create backlash? 58:48
How do we regular CRISPR used in military applications? 1:06:33
What is the regulation to be expected from CRISPR? 1:13:09
What does a CRISPR-ised world look like? 1:16:00
- published: 09 Aug 2016
- views: 105058
CRISPR
Clustered regularly-interspaced short palindromic repeats (abbreviated as CRISPR, pronounced crisper) are segments of prokaryotic DNA containing short repetitions of base sequences. Each repetition is followed by short segments of "spacer DNA" from previous exposures to a bacterial virus or plasmid.
The CRISPR/Cas system is a prokaryotic immune system that confers resistance to foreign genetic elements such as plasmids and phages, and provides a form of acquired immunity. CRISPR spacers recognize and cut these exogenous genetic elements in a manner analogous to RNA interference in eukaryotic organisms. CRISPRs are found in approximately 40% of sequenced bacteria genomes and 90% of sequenced archaea.
The CRISPR interference technique has enormous potential application, including altering the germline of humans, animals and other organisms, and modifying the genes of food crops. By delivering the Cas9 protein and appropriate guide RNAs into a cell, the organism's genome can be cut at any desired location. CRISPRs have been used in concert with specific endonuclease enzymes for genome editing and gene regulation in species throughout the tree of life. Ethical concerns have been expressed about this nascent biotechnology and the prospect of editing the human germline.
This page contains text from Wikipedia, the Free Encyclopedia -
https://wn.com/CRISPR
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
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16:04Genetic Engineering Will Change Everything Forever – CRISPR
Genetic Engineering Will Change Everything Forever – CRISPRGenetic Engineering Will Change Everything Forever – CRISPR
Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. The only thing we know for sure is that things will change irreversibly. Support us on Patreon so we can make more videos (and get cool stuff in return): https://www.patreon.com/Kurzgesagt?ty=h Kurzgesagt merch here: http://bit.ly/1P1hQIH Get the music of the video here: soundcloud: http://bit.ly/2aRxNZd bandcamp: http://bit.ly/2berrSW http://www.epic-mountain.com Thanks to Volker Henn, James Gurney and (prefers anonymity) for help with this video! THANKS A LOT TO OUR LOVELY PATRONS FOR SUPPORTING US: Jeffrey Schneider, Konstantin Kaganovich, Tom Leiser, Archie Castillo, Russell Eishard, Ben Kershaw, Marius Stollen, Henry Bowman, Ben Johns, Bogdan Radu, Sam Toland, Pierre Thalamy, Christopher Morgan, Rocks Arent People, Ross Devereux, Pascal Michaud, Derek DuBreuil, Sofia Quintero, Robert Swiniarski, Merkt Kızılırmak, Michelle Rowley, Andy Dong, Saphir Patel, Harris Rotto, Thomas Huzij, Ryan James Burke, NTRX, Chaz Lewis, Amir Resali, The War on Stupid, John Pestana, Lucien Delbert, iaDRM, Jacob Edwards, Lauritz Klaus, Jason Hunt, Marcus : ), Taylor Lau, Rhett H Eisenberg, Mr.Z, Jeremy Dumet, Fatman13, Kasturi Raghavan, Kousora, Rich Sekmistrz, Mozart Peter, Gaby Germanos, Andreas Hertle, Alena Vlachova, Zdravko Šašek SOURCES AND FURTHER READING: The best book we read about the topic: GMO Sapiens https://goo.gl/NxFmk8 (affiliate link, we get a cut if buy the book!) – Good Overview by Wired: http://bit.ly/1DuM4zq –timeline of computer development: http://bit.ly/1VtiJ0N – Selective breeding: http://bit.ly/29GaPVS – DNA: http://bit.ly/1rQs8Yk – Radiation research: http://bit.ly/2ad6wT1 – inserting DNA snippets into organisms: http://bit.ly/2apyqbj – First genetically modified animal: http://bit.ly/2abkfYO – First GM patent: http://bit.ly/2a5cCox – chemicals produced by GMOs: http://bit.ly/29UvTbh http://bit.ly/2abeHwU http://bit.ly/2a86sBy – Flavr Savr Tomato: http://bit.ly/29YPVwN – First Human Engineering: http://bit.ly/29ZTfsf – glowing fish: http://bit.ly/29UwuJU – CRISPR: http://go.nature.com/24Nhykm – HIV cut from cells and rats with CRISPR: http://go.nature.com/1RwR1xI http://ti.me/1TlADSi – first human CRISPR trials fighting cancer: http://go.nature.com/28PW40r first human CRISPR trial approved by Chinese for August 2016: http://go.nature.com/29RYNnK – genetic diseases: http://go.nature.com/2a8f7ny – pregnancies with Down Syndrome terminated: http://bit.ly/2acVyvg ( 1999 European study) – CRISPR and aging: http://bit.ly/2a3NYAV http://bit.ly/SuomTy http://go.nature.com/29WpDj1 http://ti.me/1R7Vus9 Help us caption & translate this video! http://amara.org/v/USaR/ -
7:21What is CRISPR?
What is CRISPR?What is CRISPR?
In this video Paul Andersen explains how the CRISPR/Cas immune system was identified in bacteria and how the CRISPR/Cas9 system was developed to edit genomes. Do you speak another language? Help me translate my videos: http://www.bozemanscience.com/translations/ Music Attribution Intro Title: I4dsong_loop_main.wav Artist: CosmicD Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/ Creative Commons Atribution License Outro Title: String Theory Artist: Herman Jolly http://sunsetvalley.bandcamp.com/track/string-theory All of the images are licensed under creative commons and public domain licensing: Adenosine. (2009). English: Artistic rendering of a T4 bacteriophage. The colours grey and orange do not signify anything, they are just used to illustrate structure. Created for Wikipedia. Retrieved from https://commons.wikimedia.org/wiki/File:PhageExterior.svg E. coli Bacteria. (n.d.). Retrieved February 17, 2016, from https://www.flickr.com/photos/niaid/16598492368/ Fioretti, B. F. Hallbauer &. (2015). English: Director, Max Planck Institute for Infection Biology, Department of Regulation in Infection Biology. Visiting professor The Laboratory for Molecular Infection Medicine Sweden MIMS; http://www.mpiib-berlin.mpg.de/research/regulation_in_infection_biology. Retrieved from https://commons.wikimedia.org/wiki/File:Emmanuelle_Charpentier.jpg Foresman, P. S. ([object HTMLTableCellElement]). English: Line art drawing of a chimera. Retrieved from https://commons.wikimedia.org/wiki/File:Chimera_(PSF).jpg Magladem96. (2014). English: Picture of DNA Base Flipping. Retrieved from https://commons.wikimedia.org/wiki/File:Dna-base-flipping.svg project, C. wiki. (2014). English: Crystal Structure of Cas9 bound to DNA based on the Anders et al 2014 Nature paper. Rendition was performed using UCSF’s chimera software. Retrieved from https://commons.wikimedia.org/wiki/File:Cas9_Anders_DNA_bound_structure.png Providers, P. C. (1979). English: Photomicrograph of Streptococcus pyogenes bacteria, 900x Mag. A pus specimen, viewed using Pappenheim’s stain. Last century, infections by S. pyogenes claimed many lives especially since the organism was the most important cause of puerperal fever and scarlet fever. Streptococci. Retrieved from https://commons.wikimedia.org/wiki/File:Streptococcus_pyogenes.jpg RRZEicons. (2010). English: zipper, open, close. Retrieved from https://commons.wikimedia.org/wiki/File:Zipper.svg UC Berkeley. (n.d.). Gene editing with CRISPR-Cas9. Retrieved from https://www.youtube.com/watch?v=avM1Yg5oEu0 -
8:39CRISPR: A Gene-Editing Superpower
CRISPR: A Gene-Editing SuperpowerCRISPR: A Gene-Editing Superpower
Any molecular biologist will tell you that genetic engineering is tricky. But up until recently we might be witnessing a new age in human development. Hosted by: Michael Aranda ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Dooblydoo thanks go to the following Patreon supporters -- we couldn't make SciShow without them! Shout out to Patrick Merrithew, Will and Sonja Marple, Thomas J., Kevin Bealer, Chris Peters, charles george, Kathy & Tim Philip, Tim Curwick, Bader AlGhamdi, Justin Lentz, Patrick D. Ashmore, Mark Terrio-Cameron, Benny, Fatima Iqbal, Accalia Elementia, Kyle Anderson, and Philippe von Bergen. ---------- Like SciShow? Want to help support us, and also get things to put on your walls, cover your torso and hold your liquids? Check out our awesome products over at DFTBA Records: http://dftba.com/scishow ---------- Looking for SciShow elsewhere on the internet? Facebook: http://www.facebook.com/scishow Twitter: http://www.twitter.com/scishow Tumblr: http://scishow.tumblr.com Instagram: http://instagram.com/thescishow ---------- Sources: http://www.nature.com/news/crispr-gene-editing-is-just-the-beginning-1.19510 http://www.nature.com/news/crispr-the-disruptor-1.17673 http://www.nature.com/news/biologists-create-more-precise-molecular-scissors-for-genome-editing-1.18932 http://www.theatlantic.com/science/archive/2015/12/who-edits-the-gene-editors/418209/ http://www.nature.com/nbt/journal/v33/n9/abs/nbt.3290.html http://www.theatlantic.com/science/archive/2016/01/the-most-exciting-uses-of-gene-editing-technology-involve-no-editing/422619/ http://www.nature.com/news/crispr-1.17547 https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/ http://www.yourgenome.org/facts/what-is-genetic-engineering http://wyss.harvard.edu/staticfiles/newsroom/pressreleases/Gene%20drives%20FAQ%20FINAL.pdf http://www.smithsonianmag.com/innovation/kill-all-mosquitos-180959069/?no-ist https://www.jax.org/news-and-insights/jax-blog/2014/march/pros-and-cons-of-znfs-talens-and-crispr-cas http://www.sciencemag.org/news/2016/06/human-crispr-trial-proposed http://www.nature.com/news/chinese-scientists-to-pioneer-first-human-crispr-trial-1.20302?WT.mc_id=SFB_NNEWS_1508_RHBox http://www.nature.com/news/uk-scientists-gain-licence-to-edit-genes-in-human-embryos-1.19270 http://www.nature.com/news/first-crispr-clinical-trial-gets-green-light-from-us-panel-1.20137 http://www.sciencemag.org/news/2016/04/crispr-debate-fueled-publication-second-human-embryo-editing-paper http://www.sciencemag.org/news/2015/04/chinese-paper-embryo-engineering-splits-scientific-community http://www.nature.com/news/gene-editing-method-tackles-hiv-in-first-clinical-test-1.14813 http://www.nature.com/nbt/journal/v34/n1/full/nbt.3439.html Images: https://sites.tufts.edu/crispr/crispr-background/ https://en.wikipedia.org/wiki/Anopheles#/media/File:Anopheles_stephensi.jpeg -
15:54How CRISPR lets us edit our DNA | Jennifer Doudna
How CRISPR lets us edit our DNA | Jennifer DoudnaHow CRISPR lets us edit our DNA | Jennifer Doudna
Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, called CRISPR-Cas9. The tool allows scientists to make precise edits to DNA strands, which could lead to treatments for genetic diseases … but could also be used to create so-called "designer babies." Doudna reviews how CRISPR-Cas9 works — and asks the scientific community to pause and discuss the ethics of this new tool. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more. Find closed captions and translated subtitles in many languages at http://www.ted.com/translate Follow TED news on Twitter: http://www.twitter.com/tednews Like TED on Facebook: https://www.facebook.com/TED Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector -
4:13Genome Editing with CRISPR-Cas9
Genome Editing with CRISPR-Cas9Genome Editing with CRISPR-Cas9
This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease. Feng Zhang, a leader in the development of this technology, is a faculty member at MIT, an investigator at the McGovern Institute for Brain Research, and a core member of the Broad Institute. Further information can be found on Prof. Zhang’s website at http://zlab.mit.edu . Images and footage courtesy of Sputnik Animation, the Broad Institute of MIT and Harvard, Justin Knight and pond5. -
9:54What you need to know about CRISPR | Ellen Jorgensen
What you need to know about CRISPR | Ellen JorgensenWhat you need to know about CRISPR | Ellen Jorgensen
Should we bring back the wooly mammoth? Or edit a human embryo? Or wipe out an entire species that we consider harmful? The genome-editing technology CRISPR has made extraordinary questions like these legitimate — but how does it work? Scientist and community lab advocate Ellen Jorgensen is on a mission to explain the myths and realities of CRISPR, hype-free, to the non-scientists among us. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more. Find closed captions and translated subtitles in many languages at http://www.ted.com/translate Follow TED news on Twitter: http://www.twitter.com/tednews Like TED on Facebook: https://www.facebook.com/TED Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector -
9:58The $140 Mail-Order CRISPR Kit: Is Unregulated Biohacking the Future of Science?
The $140 Mail-Order CRISPR Kit: Is Unregulated Biohacking the Future of Science?The $140 Mail-Order CRISPR Kit: Is Unregulated Biohacking the Future of Science?
What happens when you democratize science and give anyone the ability to edit DNA? Subscribe to Reason TV for daily content like this: http://bit.ly/1Ocr2AL See the full text at Reason.com: http://reason.com/reasontv/2016/06/17/biohacking-the-genome-for-just-140 MORE VIDEOS LIKE THIS: 3D Printing DNA and Hacking Life's Code: https://youtu.be/PGyNyQ5IDUM?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd WHAT OUT OF CONTROL BIOHACKING MEANS FOR THE FUTURE: https://youtu.be/3kDLwbdjRfg?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd --- "Are people dying and suffering needlessly because of all these committees and all these rules?" asks Josiah Zayner, a scientist, biohacker, and founder of the biotech company The Odin, which supplies low-cost CRISPR kits for the consumer market. "And what if people just say, 'F— you, I'm going to do it anyway'? And what if people start getting cured?" CRISPR is a gene editing system that allows scientists to modify the DNA of organisms ranging from bacteria to plants and fungus to human beings. The Odin sells kits for the the modification of bacteria and yeast. Reason TV visited Zayner in his garage lab to discuss the implications and ethics of bringing CRISPR to the masses, why he left a prestigious job in a NASA laboratory to start his own company, how regulation stifles scientific innovation, and why he believes that unregulated, decentralized experimentation will lead to the some the next great scientific breakthroughs. Watch the full interview above, or click below for downloadable versions. Approximately 10 minutes. Produced by Zach Weissmueller. Camera by Alexis Garcia. Music by Kai Engel. -
16:42Jennifer Doudna (UC Berkeley / HHMI): Genome Engineering with CRISPR-Cas9
Jennifer Doudna (UC Berkeley / HHMI): Genome Engineering with CRISPR-Cas9Jennifer Doudna (UC Berkeley / HHMI): Genome Engineering with CRISPR-Cas9
http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-birth-of-a-breakthrough-technology.html Talk Overview: Jennifer Doudna tells the story of how studying the way bacteria fight viral infection turned into a genomic engineering technology that has transformed molecular biology research. In 2013, Doudna and her colleagues developed the CRISPR-Cas9 gene expression system that, when introduced into animal cells, makes site-specific changes to intact genomes. CRISPR-Cas9 is more precise, more efficient, and less expensive than other genome editing tools and, as a result, has facilitated a wide range of studies that were previously unachievable. Speaker Biography: Jennifer Doudna is Professor of the Departments of Chemistry and of Molecular and Cell Biology at University of California, Berkeley, and an Investigator of the Howard Hughes Medical Institute. Early in her career, she studied the structure and mechanism of ribozymes (enzymatic RNA molecules) and RNA-protein complexes, such as the signal recognition particle. Now her research focuses on understanding how RNA molecules control gene expression in bacteria, through the CRISPR-Cas9 system, and eukaryotic cells, through RNA interference and microRNA-mediated translational control. For her outstanding scientific contributions, she was elected into the American Academy of Arts and Sciences in 2002 and the National Academy of Sciences in 2003, and was awarded the 2015 Breakthrough Prize in the Life Sciences. -
4:11What is CRISPR & How Could It Edit Your DNA?
What is CRISPR & How Could It Edit Your DNA?What is CRISPR & How Could It Edit Your DNA?
Gene-editing tool CRISPR is everywhere in the news, but what is it and could it eliminate disease? Sign Up For The TestTube Newsletter Here ►►►► http://bit.ly/1myXbFG Should We Make Designer Babies? ►►►►http://bit.ly/1WbDT5s Read More: CRISPR: A game-changing genetic engineering technique http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/ Have you heard? A revolution has seized the scientific community. Within only a few years, research labs worldwide have adopted a new technology that facilitates making specific changes in the DNA of humans, other animals, and plants. CRISPR gene therapy: Scientists call for more public debate around breakthrough technique http://www.independent.co.uk/news/science/crispr-gene-therapy-scientists-call-for-more-public-debate-around-breakthrough-technique-8927606.html The technique, known as CRISPR, could revolutionise human gene therapy and genetic engineering because it allows scientists for the first time to make the finest changes to the DNA of the chromosomes with relative ease. ____________________ DNews is dedicated to satisfying your curiosity and to bringing you mind-bending stories & perspectives you won't find anywhere else! New videos twice daily. Watch More DNews on TestTube http://testtube.com/dnews Subscribe now! http://www.youtube.com/subscription_center?add_user=dnewschannel DNews on Twitter http://twitter.com/dnews Trace Dominguez on Twitter https://twitter.com/tracedominguez Julia Wilde on Twitter https://ftwitter.com/julia_sci DNews on Facebook https://facebook.com/DiscoveryNews DNews on Google+ http://gplus.to/dnews Discovery News http://discoverynews.com Download the TestTube App: http://testu.be/1ndmmMq Sign Up For The TestTube Mailing List: http://dne.ws/1McUJdm -
84:26Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution
Splicing and Dicing DNA: Genome Engineering and the CRISPR RevolutionSplicing and Dicing DNA: Genome Engineering and the CRISPR Revolution
CRISPR: It’s the powerful gene editing technology transforming biomedical research. Fast, cheap and easy to use, it allows scientists to rewrite the DNA in just about any organism—including humans—with tests on human embryos already underway. The technique’s potential to radically reshape everything from disease prevention to the future of human evolution has driven explosive progress and heated debate. Join the world’s CRISPR pioneers to learn about the enormous possibilities and ethical challenges as we stand on the threshold of a brave new world of manipulating life’s fundamental code. Subscribe to our YouTube Channel for all the latest from WSF. Visit our Website: http://www.worldsciencefestival.com/ Like us on Facebook: https://www.facebook.com/worldsciencefestival Follow us on twitter: https://twitter.com/WorldSciFest Original Program Date: June 3 2016 MODERATOR: Richard Besser PARTICIPANTS: George Church, Luke Dow, Josephine Johnston, Ben Matthews, Harry Ostrer, Noel Sauer What is CRISPR? 00:05 Introduction by Richard Besser 3:58 Participant Introductions. 5:02 What is so powerful about CRISPR? 7:25 How is CRISPR is used? 13:00 How will CRISPR help eliminate Zika Virus? 20:45 Modifying 60 genes at once in a pig. 26:02 What are potential agricultural advantages from CRISPR? 28:44 If you have eaten CRISPR cells? 35:00 Using a gene drives to eliminate virus? 37:40 Creating an off switch for CRISPR 40:27 How is it ethical to not rid the world of malaria? 42:55 What is the difference between editing a germ line and editing a cancer cell? 48:27 Why would the first CRISPR baby create backlash? 58:48 How do we regular CRISPR used in military applications? 1:06:33 What is the regulation to be expected from CRISPR? 1:13:09 What does a CRISPR-ised world look like? 1:16:00
-
Genetic Engineering Will Change Everything Forever – CRISPR
Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. The only thing we know for sure is that things will change irreversibly. Support us on Patreon so we can make more videos (and get cool stuff in return): https://www.patreon.com/Kurzgesagt?ty=h Kurzgesagt merch here: http://bit.ly/1P1hQIH Get the music of the video here: soundcloud: http://bit.ly/2aRxNZd bandcamp: http://bit.ly/2berrSW http://www.epic-mountain.com Thanks to Volker Henn, James Gurney and (prefers anonymity) for help with this video! THANKS A LOT TO OUR LOVELY PATRONS FOR SUPPORTING US: Jeffrey Schneider, Konstantin Kaganovich, Tom Leiser, Archie Castillo, Russell Eishard, Ben Kershaw, Marius Stollen, H...
published: 10 Aug 2016 -
What is CRISPR?
In this video Paul Andersen explains how the CRISPR/Cas immune system was identified in bacteria and how the CRISPR/Cas9 system was developed to edit genomes. Do you speak another language? Help me translate my videos: http://www.bozemanscience.com/translations/ Music Attribution Intro Title: I4dsong_loop_main.wav Artist: CosmicD Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/ Creative Commons Atribution License Outro Title: String Theory Artist: Herman Jolly http://sunsetvalley.bandcamp.com/track/string-theory All of the images are licensed under creative commons and public domain licensing: Adenosine. (2009). English: Artistic rendering of a T4 bacteriophage. The colours grey and orange do not signify anything, they are just used to illustrate structure. Creat...
published: 18 Feb 2016 -
CRISPR: A Gene-Editing Superpower
Any molecular biologist will tell you that genetic engineering is tricky. But up until recently we might be witnessing a new age in human development. Hosted by: Michael Aranda ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Dooblydoo thanks go to the following Patreon supporters -- we couldn't make SciShow without them! Shout out to Patrick Merrithew, Will and Sonja Marple, Thomas J., Kevin Bealer, Chris Peters, charles george, Kathy & Tim Philip, Tim Curwick, Bader AlGhamdi, Justin Lentz, Patrick D. Ashmore, Mark Terrio-Cameron, Benny, Fatima Iqbal, Accalia Elementia, Kyle Anderson, and Philippe von Bergen. ---------- Like SciShow? Want to help support us, and also get things to put on your walls, cover your torso and hold your liq...
published: 31 Aug 2016 -
How CRISPR lets us edit our DNA | Jennifer Doudna
Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, called CRISPR-Cas9. The tool allows scientists to make precise edits to DNA strands, which could lead to treatments for genetic diseases … but could also be used to create so-called "designer babies." Doudna reviews how CRISPR-Cas9 works — and asks the scientific community to pause and discuss the ethics of this new tool. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more. Find closed captions and translated subtitles in many languages at http...
published: 12 Nov 2015 -
Genome Editing with CRISPR-Cas9
This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease. Feng Zhang, a leader in the development of this technology, is a faculty member at MIT, an investigator at the McGovern Institute for Brain Research, and a core member of the Broad Institute. Further information can be found on Prof. Zhang’s website at http://zlab.mit.edu . Images and footage courtesy of Sputnik Animation, the Broad Institute of MIT and Harvard, Justin Knight and pond5.
published: 05 Nov 2014 -
What you need to know about CRISPR | Ellen Jorgensen
Should we bring back the wooly mammoth? Or edit a human embryo? Or wipe out an entire species that we consider harmful? The genome-editing technology CRISPR has made extraordinary questions like these legitimate — but how does it work? Scientist and community lab advocate Ellen Jorgensen is on a mission to explain the myths and realities of CRISPR, hype-free, to the non-scientists among us. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more. Find closed captions and translated subtitles in many languages at http://www.ted.com/trans...
published: 24 Oct 2016 -
The $140 Mail-Order CRISPR Kit: Is Unregulated Biohacking the Future of Science?
What happens when you democratize science and give anyone the ability to edit DNA? Subscribe to Reason TV for daily content like this: http://bit.ly/1Ocr2AL See the full text at Reason.com: http://reason.com/reasontv/2016/06/17/biohacking-the-genome-for-just-140 MORE VIDEOS LIKE THIS: 3D Printing DNA and Hacking Life's Code: https://youtu.be/PGyNyQ5IDUM?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd WHAT OUT OF CONTROL BIOHACKING MEANS FOR THE FUTURE: https://youtu.be/3kDLwbdjRfg?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd --- "Are people dying and suffering needlessly because of all these committees and all these rules?" asks Josiah Zayner, a scientist, biohacker, and founder of the biotech company The Odin, which supplies low-cost CRISPR kits for the consumer market. "And what if people j...
published: 20 Jun 2016 -
Jennifer Doudna (UC Berkeley / HHMI): Genome Engineering with CRISPR-Cas9
http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-birth-of-a-breakthrough-technology.html Talk Overview: Jennifer Doudna tells the story of how studying the way bacteria fight viral infection turned into a genomic engineering technology that has transformed molecular biology research. In 2013, Doudna and her colleagues developed the CRISPR-Cas9 gene expression system that, when introduced into animal cells, makes site-specific changes to intact genomes. CRISPR-Cas9 is more precise, more efficient, and less expensive than other genome editing tools and, as a result, has facilitated a wide range of studies that were previously unachievable. Speaker Biography: Jennifer Doudna is Professor of the Departments of Chemistry and of Molecular and Cell Biolo...
published: 23 Mar 2015 -
What is CRISPR & How Could It Edit Your DNA?
Gene-editing tool CRISPR is everywhere in the news, but what is it and could it eliminate disease? Sign Up For The TestTube Newsletter Here ►►►► http://bit.ly/1myXbFG Should We Make Designer Babies? ►►►►http://bit.ly/1WbDT5s Read More: CRISPR: A game-changing genetic engineering technique http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/ Have you heard? A revolution has seized the scientific community. Within only a few years, research labs worldwide have adopted a new technology that facilitates making specific changes in the DNA of humans, other animals, and plants. CRISPR gene therapy: Scientists call for more public debate around breakthrough technique http://www.independent.co.uk/news/science/crispr-gene-therapy-scientists-ca...
published: 15 Jan 2016 -
Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution
CRISPR: It’s the powerful gene editing technology transforming biomedical research. Fast, cheap and easy to use, it allows scientists to rewrite the DNA in just about any organism—including humans—with tests on human embryos already underway. The technique’s potential to radically reshape everything from disease prevention to the future of human evolution has driven explosive progress and heated debate. Join the world’s CRISPR pioneers to learn about the enormous possibilities and ethical challenges as we stand on the threshold of a brave new world of manipulating life’s fundamental code. Subscribe to our YouTube Channel for all the latest from WSF. Visit our Website: http://www.worldsciencefestival.com/ Like us on Facebook: https://www.facebook.com/worldsciencefestival Follow us on twitt...
published: 09 Aug 2016
Genetic Engineering Will Change Everything Forever – CRISPR
- Order: Reorder
- Duration: 16:04
- Updated: 10 Aug 2016
- views: 4059933
Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming realit...
Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. The only thing we know for sure is that things will change irreversibly.
Support us on Patreon so we can make more videos (and get cool stuff in return): https://www.patreon.com/Kurzgesagt?ty=h
Kurzgesagt merch here: http://bit.ly/1P1hQIH
Get the music of the video here:
soundcloud: http://bit.ly/2aRxNZd
bandcamp: http://bit.ly/2berrSW
http://www.epic-mountain.com
Thanks to Volker Henn, James Gurney and (prefers anonymity) for help with this video!
THANKS A LOT TO OUR LOVELY PATRONS FOR SUPPORTING US:
Jeffrey Schneider, Konstantin Kaganovich, Tom Leiser, Archie Castillo, Russell Eishard, Ben Kershaw, Marius Stollen, Henry Bowman, Ben Johns, Bogdan Radu, Sam Toland, Pierre Thalamy, Christopher Morgan, Rocks Arent People, Ross Devereux, Pascal Michaud, Derek DuBreuil, Sofia Quintero, Robert Swiniarski, Merkt Kızılırmak, Michelle Rowley, Andy Dong, Saphir Patel, Harris Rotto, Thomas Huzij, Ryan James Burke, NTRX, Chaz Lewis, Amir Resali, The War on Stupid, John Pestana, Lucien Delbert, iaDRM, Jacob Edwards, Lauritz Klaus, Jason Hunt, Marcus : ), Taylor Lau, Rhett H Eisenberg, Mr.Z, Jeremy Dumet, Fatman13, Kasturi Raghavan, Kousora, Rich Sekmistrz, Mozart Peter, Gaby Germanos, Andreas Hertle, Alena Vlachova, Zdravko Šašek
SOURCES AND FURTHER READING:
The best book we read about the topic: GMO Sapiens
https://goo.gl/NxFmk8
(affiliate link, we get a cut if buy the book!)
– Good Overview by Wired:
http://bit.ly/1DuM4zq
–timeline of computer development:
http://bit.ly/1VtiJ0N
– Selective breeding:
http://bit.ly/29GaPVS
– DNA:
http://bit.ly/1rQs8Yk
– Radiation research:
http://bit.ly/2ad6wT1
– inserting DNA snippets into organisms:
http://bit.ly/2apyqbj
– First genetically modified animal:
http://bit.ly/2abkfYO
– First GM patent:
http://bit.ly/2a5cCox
– chemicals produced by GMOs:
http://bit.ly/29UvTbh
http://bit.ly/2abeHwU
http://bit.ly/2a86sBy
– Flavr Savr Tomato:
http://bit.ly/29YPVwN
– First Human Engineering:
http://bit.ly/29ZTfsf
– glowing fish:
http://bit.ly/29UwuJU
– CRISPR:
http://go.nature.com/24Nhykm
– HIV cut from cells and rats with CRISPR:
http://go.nature.com/1RwR1xI
http://ti.me/1TlADSi
– first human CRISPR trials fighting cancer:
http://go.nature.com/28PW40r
first human CRISPR trial approved by Chinese for August 2016:
http://go.nature.com/29RYNnK
– genetic diseases:
http://go.nature.com/2a8f7ny
– pregnancies with Down Syndrome terminated:
http://bit.ly/2acVyvg
( 1999 European study)
– CRISPR and aging:
http://bit.ly/2a3NYAV
http://bit.ly/SuomTy
http://go.nature.com/29WpDj1
http://ti.me/1R7Vus9
Help us caption & translate this video!
http://amara.org/v/USaR/
wn.com/Genetic Engineering Will Change Everything Forever – Crispr
Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. The only thing we know for sure is that things will change irreversibly.
Support us on Patreon so we can make more videos (and get cool stuff in return): https://www.patreon.com/Kurzgesagt?ty=h
Kurzgesagt merch here: http://bit.ly/1P1hQIH
Get the music of the video here:
soundcloud: http://bit.ly/2aRxNZd
bandcamp: http://bit.ly/2berrSW
http://www.epic-mountain.com
Thanks to Volker Henn, James Gurney and (prefers anonymity) for help with this video!
THANKS A LOT TO OUR LOVELY PATRONS FOR SUPPORTING US:
Jeffrey Schneider, Konstantin Kaganovich, Tom Leiser, Archie Castillo, Russell Eishard, Ben Kershaw, Marius Stollen, Henry Bowman, Ben Johns, Bogdan Radu, Sam Toland, Pierre Thalamy, Christopher Morgan, Rocks Arent People, Ross Devereux, Pascal Michaud, Derek DuBreuil, Sofia Quintero, Robert Swiniarski, Merkt Kızılırmak, Michelle Rowley, Andy Dong, Saphir Patel, Harris Rotto, Thomas Huzij, Ryan James Burke, NTRX, Chaz Lewis, Amir Resali, The War on Stupid, John Pestana, Lucien Delbert, iaDRM, Jacob Edwards, Lauritz Klaus, Jason Hunt, Marcus : ), Taylor Lau, Rhett H Eisenberg, Mr.Z, Jeremy Dumet, Fatman13, Kasturi Raghavan, Kousora, Rich Sekmistrz, Mozart Peter, Gaby Germanos, Andreas Hertle, Alena Vlachova, Zdravko Šašek
SOURCES AND FURTHER READING:
The best book we read about the topic: GMO Sapiens
https://goo.gl/NxFmk8
(affiliate link, we get a cut if buy the book!)
– Good Overview by Wired:
http://bit.ly/1DuM4zq
–timeline of computer development:
http://bit.ly/1VtiJ0N
– Selective breeding:
http://bit.ly/29GaPVS
– DNA:
http://bit.ly/1rQs8Yk
– Radiation research:
http://bit.ly/2ad6wT1
– inserting DNA snippets into organisms:
http://bit.ly/2apyqbj
– First genetically modified animal:
http://bit.ly/2abkfYO
– First GM patent:
http://bit.ly/2a5cCox
– chemicals produced by GMOs:
http://bit.ly/29UvTbh
http://bit.ly/2abeHwU
http://bit.ly/2a86sBy
– Flavr Savr Tomato:
http://bit.ly/29YPVwN
– First Human Engineering:
http://bit.ly/29ZTfsf
– glowing fish:
http://bit.ly/29UwuJU
– CRISPR:
http://go.nature.com/24Nhykm
– HIV cut from cells and rats with CRISPR:
http://go.nature.com/1RwR1xI
http://ti.me/1TlADSi
– first human CRISPR trials fighting cancer:
http://go.nature.com/28PW40r
first human CRISPR trial approved by Chinese for August 2016:
http://go.nature.com/29RYNnK
– genetic diseases:
http://go.nature.com/2a8f7ny
– pregnancies with Down Syndrome terminated:
http://bit.ly/2acVyvg
( 1999 European study)
– CRISPR and aging:
http://bit.ly/2a3NYAV
http://bit.ly/SuomTy
http://go.nature.com/29WpDj1
http://ti.me/1R7Vus9
Help us caption & translate this video!
http://amara.org/v/USaR/
- published: 10 Aug 2016
- views: 4059933
What is CRISPR?
- Order: Reorder
- Duration: 7:21
- Updated: 18 Feb 2016
- views: 179221
In this video Paul Andersen explains how the CRISPR/Cas immune system was identified in bacteria and how the CRISPR/Cas9 system was developed to edit genomes.
...
In this video Paul Andersen explains how the CRISPR/Cas immune system was identified in bacteria and how the CRISPR/Cas9 system was developed to edit genomes.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Music Attribution
Intro
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
Outro
Title: String Theory
Artist: Herman Jolly
http://sunsetvalley.bandcamp.com/track/string-theory
All of the images are licensed under creative commons and public domain licensing:
Adenosine. (2009). English: Artistic rendering of a T4 bacteriophage. The colours grey and orange do not signify anything, they are just used to illustrate structure. Created for Wikipedia. Retrieved from https://commons.wikimedia.org/wiki/File:PhageExterior.svg
E. coli Bacteria. (n.d.). Retrieved February 17, 2016, from https://www.flickr.com/photos/niaid/16598492368/
Fioretti, B. F. Hallbauer &. (2015). English: Director, Max Planck Institute for Infection Biology, Department of Regulation in Infection Biology. Visiting professor The Laboratory for Molecular Infection Medicine Sweden MIMS; http://www.mpiib-berlin.mpg.de/research/regulation_in_infection_biology. Retrieved from https://commons.wikimedia.org/wiki/File:Emmanuelle_Charpentier.jpg
Foresman, P. S. ([object HTMLTableCellElement]). English: Line art drawing of a chimera. Retrieved from https://commons.wikimedia.org/wiki/File:Chimera_(PSF).jpg
Magladem96. (2014). English: Picture of DNA Base Flipping. Retrieved from https://commons.wikimedia.org/wiki/File:Dna-base-flipping.svg
project, C. wiki. (2014). English: Crystal Structure of Cas9 bound to DNA based on the Anders et al 2014 Nature paper. Rendition was performed using UCSF’s chimera software. Retrieved from https://commons.wikimedia.org/wiki/File:Cas9_Anders_DNA_bound_structure.png
Providers, P. C. (1979). English: Photomicrograph of Streptococcus pyogenes bacteria, 900x Mag. A pus specimen, viewed using Pappenheim’s stain. Last century, infections by S. pyogenes claimed many lives especially since the organism was the most important cause of puerperal fever and scarlet fever. Streptococci. Retrieved from https://commons.wikimedia.org/wiki/File:Streptococcus_pyogenes.jpg
RRZEicons. (2010). English: zipper, open, close. Retrieved from https://commons.wikimedia.org/wiki/File:Zipper.svg
UC Berkeley. (n.d.). Gene editing with CRISPR-Cas9. Retrieved from https://www.youtube.com/watch?v=avM1Yg5oEu0
wn.com/What Is Crispr
In this video Paul Andersen explains how the CRISPR/Cas immune system was identified in bacteria and how the CRISPR/Cas9 system was developed to edit genomes.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Music Attribution
Intro
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
Outro
Title: String Theory
Artist: Herman Jolly
http://sunsetvalley.bandcamp.com/track/string-theory
All of the images are licensed under creative commons and public domain licensing:
Adenosine. (2009). English: Artistic rendering of a T4 bacteriophage. The colours grey and orange do not signify anything, they are just used to illustrate structure. Created for Wikipedia. Retrieved from https://commons.wikimedia.org/wiki/File:PhageExterior.svg
E. coli Bacteria. (n.d.). Retrieved February 17, 2016, from https://www.flickr.com/photos/niaid/16598492368/
Fioretti, B. F. Hallbauer &. (2015). English: Director, Max Planck Institute for Infection Biology, Department of Regulation in Infection Biology. Visiting professor The Laboratory for Molecular Infection Medicine Sweden MIMS; http://www.mpiib-berlin.mpg.de/research/regulation_in_infection_biology. Retrieved from https://commons.wikimedia.org/wiki/File:Emmanuelle_Charpentier.jpg
Foresman, P. S. ([object HTMLTableCellElement]). English: Line art drawing of a chimera. Retrieved from https://commons.wikimedia.org/wiki/File:Chimera_(PSF).jpg
Magladem96. (2014). English: Picture of DNA Base Flipping. Retrieved from https://commons.wikimedia.org/wiki/File:Dna-base-flipping.svg
project, C. wiki. (2014). English: Crystal Structure of Cas9 bound to DNA based on the Anders et al 2014 Nature paper. Rendition was performed using UCSF’s chimera software. Retrieved from https://commons.wikimedia.org/wiki/File:Cas9_Anders_DNA_bound_structure.png
Providers, P. C. (1979). English: Photomicrograph of Streptococcus pyogenes bacteria, 900x Mag. A pus specimen, viewed using Pappenheim’s stain. Last century, infections by S. pyogenes claimed many lives especially since the organism was the most important cause of puerperal fever and scarlet fever. Streptococci. Retrieved from https://commons.wikimedia.org/wiki/File:Streptococcus_pyogenes.jpg
RRZEicons. (2010). English: zipper, open, close. Retrieved from https://commons.wikimedia.org/wiki/File:Zipper.svg
UC Berkeley. (n.d.). Gene editing with CRISPR-Cas9. Retrieved from https://www.youtube.com/watch?v=avM1Yg5oEu0
- published: 18 Feb 2016
- views: 179221
CRISPR: A Gene-Editing Superpower
- Order: Reorder
- Duration: 8:39
- Updated: 31 Aug 2016
- views: 314548
Any molecular biologist will tell you that genetic engineering is tricky. But up until recently we might be witnessing a new age in human development.
Hosted ...
Any molecular biologist will tell you that genetic engineering is tricky. But up until recently we might be witnessing a new age in human development.
Hosted by: Michael Aranda
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Sources:
http://www.nature.com/news/crispr-gene-editing-is-just-the-beginning-1.19510
http://www.nature.com/news/crispr-the-disruptor-1.17673
http://www.nature.com/news/biologists-create-more-precise-molecular-scissors-for-genome-editing-1.18932
http://www.theatlantic.com/science/archive/2015/12/who-edits-the-gene-editors/418209/
http://www.nature.com/nbt/journal/v33/n9/abs/nbt.3290.html
http://www.theatlantic.com/science/archive/2016/01/the-most-exciting-uses-of-gene-editing-technology-involve-no-editing/422619/
http://www.nature.com/news/crispr-1.17547
https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr
http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/
http://www.yourgenome.org/facts/what-is-genetic-engineering
http://wyss.harvard.edu/staticfiles/newsroom/pressreleases/Gene%20drives%20FAQ%20FINAL.pdf
http://www.smithsonianmag.com/innovation/kill-all-mosquitos-180959069/?no-ist
https://www.jax.org/news-and-insights/jax-blog/2014/march/pros-and-cons-of-znfs-talens-and-crispr-cas
http://www.sciencemag.org/news/2016/06/human-crispr-trial-proposed
http://www.nature.com/news/chinese-scientists-to-pioneer-first-human-crispr-trial-1.20302?WT.mc_id=SFB_NNEWS_1508_RHBox
http://www.nature.com/news/uk-scientists-gain-licence-to-edit-genes-in-human-embryos-1.19270
http://www.nature.com/news/first-crispr-clinical-trial-gets-green-light-from-us-panel-1.20137
http://www.sciencemag.org/news/2016/04/crispr-debate-fueled-publication-second-human-embryo-editing-paper
http://www.sciencemag.org/news/2015/04/chinese-paper-embryo-engineering-splits-scientific-community
http://www.nature.com/news/gene-editing-method-tackles-hiv-in-first-clinical-test-1.14813
http://www.nature.com/nbt/journal/v34/n1/full/nbt.3439.html
Images:
https://sites.tufts.edu/crispr/crispr-background/
https://en.wikipedia.org/wiki/Anopheles#/media/File:Anopheles_stephensi.jpeg
wn.com/Crispr A Gene Editing Superpower
Any molecular biologist will tell you that genetic engineering is tricky. But up until recently we might be witnessing a new age in human development.
Hosted by: Michael Aranda
----------
Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow
----------
Dooblydoo thanks go to the following Patreon supporters -- we couldn't make SciShow without them! Shout out to Patrick Merrithew, Will and Sonja Marple, Thomas J., Kevin Bealer, Chris Peters, charles george, Kathy & Tim Philip, Tim Curwick, Bader AlGhamdi, Justin Lentz, Patrick D. Ashmore, Mark Terrio-Cameron, Benny, Fatima Iqbal, Accalia Elementia, Kyle Anderson, and Philippe von Bergen.
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Like SciShow? Want to help support us, and also get things to put on your walls, cover your torso and hold your liquids? Check out our awesome products over at DFTBA Records: http://dftba.com/scishow
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Sources:
http://www.nature.com/news/crispr-gene-editing-is-just-the-beginning-1.19510
http://www.nature.com/news/crispr-the-disruptor-1.17673
http://www.nature.com/news/biologists-create-more-precise-molecular-scissors-for-genome-editing-1.18932
http://www.theatlantic.com/science/archive/2015/12/who-edits-the-gene-editors/418209/
http://www.nature.com/nbt/journal/v33/n9/abs/nbt.3290.html
http://www.theatlantic.com/science/archive/2016/01/the-most-exciting-uses-of-gene-editing-technology-involve-no-editing/422619/
http://www.nature.com/news/crispr-1.17547
https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr
http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/
http://www.yourgenome.org/facts/what-is-genetic-engineering
http://wyss.harvard.edu/staticfiles/newsroom/pressreleases/Gene%20drives%20FAQ%20FINAL.pdf
http://www.smithsonianmag.com/innovation/kill-all-mosquitos-180959069/?no-ist
https://www.jax.org/news-and-insights/jax-blog/2014/march/pros-and-cons-of-znfs-talens-and-crispr-cas
http://www.sciencemag.org/news/2016/06/human-crispr-trial-proposed
http://www.nature.com/news/chinese-scientists-to-pioneer-first-human-crispr-trial-1.20302?WT.mc_id=SFB_NNEWS_1508_RHBox
http://www.nature.com/news/uk-scientists-gain-licence-to-edit-genes-in-human-embryos-1.19270
http://www.nature.com/news/first-crispr-clinical-trial-gets-green-light-from-us-panel-1.20137
http://www.sciencemag.org/news/2016/04/crispr-debate-fueled-publication-second-human-embryo-editing-paper
http://www.sciencemag.org/news/2015/04/chinese-paper-embryo-engineering-splits-scientific-community
http://www.nature.com/news/gene-editing-method-tackles-hiv-in-first-clinical-test-1.14813
http://www.nature.com/nbt/journal/v34/n1/full/nbt.3439.html
Images:
https://sites.tufts.edu/crispr/crispr-background/
https://en.wikipedia.org/wiki/Anopheles#/media/File:Anopheles_stephensi.jpeg
- published: 31 Aug 2016
- views: 314548
How CRISPR lets us edit our DNA | Jennifer Doudna
- Order: Reorder
- Duration: 15:54
- Updated: 12 Nov 2015
- views: 230069
Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, called CRISPR-Cas9. The tool allows scientists to make precise edits t...
Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, called CRISPR-Cas9. The tool allows scientists to make precise edits to DNA strands, which could lead to treatments for genetic diseases … but could also be used to create so-called "designer babies." Doudna reviews how CRISPR-Cas9 works — and asks the scientific community to pause and discuss the ethics of this new tool.
TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at http://www.ted.com/translate
Follow TED news on Twitter: http://www.twitter.com/tednews
Like TED on Facebook: https://www.facebook.com/TED
Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector
wn.com/How Crispr Lets US Edit Our Dna | Jennifer Doudna
Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, called CRISPR-Cas9. The tool allows scientists to make precise edits to DNA strands, which could lead to treatments for genetic diseases … but could also be used to create so-called "designer babies." Doudna reviews how CRISPR-Cas9 works — and asks the scientific community to pause and discuss the ethics of this new tool.
TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at http://www.ted.com/translate
Follow TED news on Twitter: http://www.twitter.com/tednews
Like TED on Facebook: https://www.facebook.com/TED
Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector
- published: 12 Nov 2015
- views: 230069
Genome Editing with CRISPR-Cas9
- Order: Reorder
- Duration: 4:13
- Updated: 05 Nov 2014
- views: 804766
This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technology with many applications in biomedical research, including the potent...
This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease. Feng Zhang, a leader in the development of this technology, is a faculty member at MIT, an investigator at the McGovern Institute for Brain Research, and a core member of the Broad Institute. Further information can be found on Prof. Zhang’s website at http://zlab.mit.edu .
Images and footage courtesy of Sputnik Animation, the Broad Institute of MIT and Harvard, Justin Knight and pond5.
wn.com/Genome Editing With Crispr Cas9
This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease. Feng Zhang, a leader in the development of this technology, is a faculty member at MIT, an investigator at the McGovern Institute for Brain Research, and a core member of the Broad Institute. Further information can be found on Prof. Zhang’s website at http://zlab.mit.edu .
Images and footage courtesy of Sputnik Animation, the Broad Institute of MIT and Harvard, Justin Knight and pond5.
- published: 05 Nov 2014
- views: 804766
What you need to know about CRISPR | Ellen Jorgensen
- Order: Reorder
- Duration: 9:54
- Updated: 24 Oct 2016
- views: 66322
Should we bring back the wooly mammoth? Or edit a human embryo? Or wipe out an entire species that we consider harmful? The genome-editing technology CRISPR has...
Should we bring back the wooly mammoth? Or edit a human embryo? Or wipe out an entire species that we consider harmful? The genome-editing technology CRISPR has made extraordinary questions like these legitimate — but how does it work? Scientist and community lab advocate Ellen Jorgensen is on a mission to explain the myths and realities of CRISPR, hype-free, to the non-scientists among us.
TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at http://www.ted.com/translate
Follow TED news on Twitter: http://www.twitter.com/tednews
Like TED on Facebook: https://www.facebook.com/TED
Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector
wn.com/What You Need To Know About Crispr | Ellen Jorgensen
Should we bring back the wooly mammoth? Or edit a human embryo? Or wipe out an entire species that we consider harmful? The genome-editing technology CRISPR has made extraordinary questions like these legitimate — but how does it work? Scientist and community lab advocate Ellen Jorgensen is on a mission to explain the myths and realities of CRISPR, hype-free, to the non-scientists among us.
TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at http://www.ted.com/translate
Follow TED news on Twitter: http://www.twitter.com/tednews
Like TED on Facebook: https://www.facebook.com/TED
Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector
- published: 24 Oct 2016
- views: 66322
The $140 Mail-Order CRISPR Kit: Is Unregulated Biohacking the Future of Science?
- Order: Reorder
- Duration: 9:58
- Updated: 20 Jun 2016
- views: 31948
What happens when you democratize science and give anyone the ability to edit DNA?
Subscribe to Reason TV for daily content like this: http://bit.ly/1Ocr2AL
S...
What happens when you democratize science and give anyone the ability to edit DNA?
Subscribe to Reason TV for daily content like this: http://bit.ly/1Ocr2AL
See the full text at Reason.com: http://reason.com/reasontv/2016/06/17/biohacking-the-genome-for-just-140
MORE VIDEOS LIKE THIS:
3D Printing DNA and Hacking Life's Code:
https://youtu.be/PGyNyQ5IDUM?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd
WHAT OUT OF CONTROL BIOHACKING MEANS FOR THE FUTURE:
https://youtu.be/3kDLwbdjRfg?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd
---
"Are people dying and suffering needlessly because of all these committees and all these rules?" asks Josiah Zayner, a scientist, biohacker, and founder of the biotech company The Odin, which supplies low-cost CRISPR kits for the consumer market. "And what if people just say, 'F— you, I'm going to do it anyway'? And what if people start getting cured?"
CRISPR is a gene editing system that allows scientists to modify the DNA of organisms ranging from bacteria to plants and fungus to human beings. The Odin sells kits for the the modification of bacteria and yeast.
Reason TV visited Zayner in his garage lab to discuss the implications and ethics of bringing CRISPR to the masses, why he left a prestigious job in a NASA laboratory to start his own company, how regulation stifles scientific innovation, and why he believes that unregulated, decentralized experimentation will lead to the some the next great scientific breakthroughs.
Watch the full interview above, or click below for downloadable versions. Approximately 10 minutes. Produced by Zach Weissmueller. Camera by Alexis Garcia. Music by Kai Engel.
wn.com/The 140 Mail Order Crispr Kit Is Unregulated Biohacking The Future Of Science
What happens when you democratize science and give anyone the ability to edit DNA?
Subscribe to Reason TV for daily content like this: http://bit.ly/1Ocr2AL
See the full text at Reason.com: http://reason.com/reasontv/2016/06/17/biohacking-the-genome-for-just-140
MORE VIDEOS LIKE THIS:
3D Printing DNA and Hacking Life's Code:
https://youtu.be/PGyNyQ5IDUM?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd
WHAT OUT OF CONTROL BIOHACKING MEANS FOR THE FUTURE:
https://youtu.be/3kDLwbdjRfg?list=PLBuns9Evn1w-HAmPqs14A5JpEXoQt2Oqd
---
"Are people dying and suffering needlessly because of all these committees and all these rules?" asks Josiah Zayner, a scientist, biohacker, and founder of the biotech company The Odin, which supplies low-cost CRISPR kits for the consumer market. "And what if people just say, 'F— you, I'm going to do it anyway'? And what if people start getting cured?"
CRISPR is a gene editing system that allows scientists to modify the DNA of organisms ranging from bacteria to plants and fungus to human beings. The Odin sells kits for the the modification of bacteria and yeast.
Reason TV visited Zayner in his garage lab to discuss the implications and ethics of bringing CRISPR to the masses, why he left a prestigious job in a NASA laboratory to start his own company, how regulation stifles scientific innovation, and why he believes that unregulated, decentralized experimentation will lead to the some the next great scientific breakthroughs.
Watch the full interview above, or click below for downloadable versions. Approximately 10 minutes. Produced by Zach Weissmueller. Camera by Alexis Garcia. Music by Kai Engel.
- published: 20 Jun 2016
- views: 31948
Jennifer Doudna (UC Berkeley / HHMI): Genome Engineering with CRISPR-Cas9
- Order: Reorder
- Duration: 16:42
- Updated: 23 Mar 2015
- views: 240761
http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-birth-of-a-breakthrough-technology.html
Talk Overview:
Jennifer Doudna...
http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-birth-of-a-breakthrough-technology.html
Talk Overview:
Jennifer Doudna tells the story of how studying the way bacteria fight viral infection turned into a genomic engineering technology that has transformed molecular biology research. In 2013, Doudna and her colleagues developed the CRISPR-Cas9 gene expression system that, when introduced into animal cells, makes site-specific changes to intact genomes. CRISPR-Cas9 is more precise, more efficient, and less expensive than other genome editing tools and, as a result, has facilitated a wide range of studies that were previously unachievable.
Speaker Biography:
Jennifer Doudna is Professor of the Departments of Chemistry and of Molecular and Cell Biology at University of California, Berkeley, and an Investigator of the Howard Hughes Medical Institute. Early in her career, she studied the structure and mechanism of ribozymes (enzymatic RNA molecules) and RNA-protein complexes, such as the signal recognition particle. Now her research focuses on understanding how RNA molecules control gene expression in bacteria, through the CRISPR-Cas9 system, and eukaryotic cells, through RNA interference and microRNA-mediated translational control. For her outstanding scientific contributions, she was elected into the American Academy of Arts and Sciences in 2002 and the National Academy of Sciences in 2003, and was awarded the 2015 Breakthrough Prize in the Life Sciences.
wn.com/Jennifer Doudna (Uc Berkeley Hhmi) Genome Engineering With Crispr Cas9
http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-birth-of-a-breakthrough-technology.html
Talk Overview:
Jennifer Doudna tells the story of how studying the way bacteria fight viral infection turned into a genomic engineering technology that has transformed molecular biology research. In 2013, Doudna and her colleagues developed the CRISPR-Cas9 gene expression system that, when introduced into animal cells, makes site-specific changes to intact genomes. CRISPR-Cas9 is more precise, more efficient, and less expensive than other genome editing tools and, as a result, has facilitated a wide range of studies that were previously unachievable.
Speaker Biography:
Jennifer Doudna is Professor of the Departments of Chemistry and of Molecular and Cell Biology at University of California, Berkeley, and an Investigator of the Howard Hughes Medical Institute. Early in her career, she studied the structure and mechanism of ribozymes (enzymatic RNA molecules) and RNA-protein complexes, such as the signal recognition particle. Now her research focuses on understanding how RNA molecules control gene expression in bacteria, through the CRISPR-Cas9 system, and eukaryotic cells, through RNA interference and microRNA-mediated translational control. For her outstanding scientific contributions, she was elected into the American Academy of Arts and Sciences in 2002 and the National Academy of Sciences in 2003, and was awarded the 2015 Breakthrough Prize in the Life Sciences.
- published: 23 Mar 2015
- views: 240761
What is CRISPR & How Could It Edit Your DNA?
- Order: Reorder
- Duration: 4:11
- Updated: 15 Jan 2016
- views: 93036
Gene-editing tool CRISPR is everywhere in the news, but what is it and could it eliminate disease?
Sign Up For The TestTube Newsletter Here ►►►► http://bit....
Gene-editing tool CRISPR is everywhere in the news, but what is it and could it eliminate disease?
Sign Up For The TestTube Newsletter Here ►►►► http://bit.ly/1myXbFG
Should We Make Designer Babies? ►►►►http://bit.ly/1WbDT5s
Read More:
CRISPR: A game-changing genetic engineering technique
http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/
Have you heard? A revolution has seized the scientific community. Within only a few years, research labs worldwide have adopted a new technology that facilitates making specific changes in the DNA of humans, other animals, and plants.
CRISPR gene therapy: Scientists call for more public debate around breakthrough technique
http://www.independent.co.uk/news/science/crispr-gene-therapy-scientists-call-for-more-public-debate-around-breakthrough-technique-8927606.html
The technique, known as CRISPR, could revolutionise human gene therapy and genetic engineering because it allows scientists for the first time to make the finest changes to the DNA of the chromosomes with relative ease.
____________________
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wn.com/What Is Crispr How Could It Edit Your Dna
Gene-editing tool CRISPR is everywhere in the news, but what is it and could it eliminate disease?
Sign Up For The TestTube Newsletter Here ►►►► http://bit.ly/1myXbFG
Should We Make Designer Babies? ►►►►http://bit.ly/1WbDT5s
Read More:
CRISPR: A game-changing genetic engineering technique
http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/
Have you heard? A revolution has seized the scientific community. Within only a few years, research labs worldwide have adopted a new technology that facilitates making specific changes in the DNA of humans, other animals, and plants.
CRISPR gene therapy: Scientists call for more public debate around breakthrough technique
http://www.independent.co.uk/news/science/crispr-gene-therapy-scientists-call-for-more-public-debate-around-breakthrough-technique-8927606.html
The technique, known as CRISPR, could revolutionise human gene therapy and genetic engineering because it allows scientists for the first time to make the finest changes to the DNA of the chromosomes with relative ease.
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- published: 15 Jan 2016
- views: 93036
Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution
- Order: Reorder
- Duration: 84:26
- Updated: 09 Aug 2016
- views: 105058
CRISPR: It’s the powerful gene editing technology transforming biomedical research. Fast, cheap and easy to use, it allows scientists to rewrite the DNA in just...
CRISPR: It’s the powerful gene editing technology transforming biomedical research. Fast, cheap and easy to use, it allows scientists to rewrite the DNA in just about any organism—including humans—with tests on human embryos already underway. The technique’s potential to radically reshape everything from disease prevention to the future of human evolution has driven explosive progress and heated debate. Join the world’s CRISPR pioneers to learn about the enormous possibilities and ethical challenges as we stand on the threshold of a brave new world of manipulating life’s fundamental code.
Subscribe to our YouTube Channel for all the latest from WSF.
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Original Program Date: June 3 2016
MODERATOR: Richard Besser
PARTICIPANTS: George Church, Luke Dow, Josephine Johnston, Ben Matthews, Harry Ostrer, Noel Sauer
What is CRISPR? 00:05
Introduction by Richard Besser 3:58
Participant Introductions. 5:02
What is so powerful about CRISPR? 7:25
How is CRISPR is used? 13:00
How will CRISPR help eliminate Zika Virus? 20:45
Modifying 60 genes at once in a pig. 26:02
What are potential agricultural advantages from CRISPR? 28:44
If you have eaten CRISPR cells? 35:00
Using a gene drives to eliminate virus? 37:40
Creating an off switch for CRISPR 40:27
How is it ethical to not rid the world of malaria? 42:55
What is the difference between editing a germ line and editing a cancer cell? 48:27
Why would the first CRISPR baby create backlash? 58:48
How do we regular CRISPR used in military applications? 1:06:33
What is the regulation to be expected from CRISPR? 1:13:09
What does a CRISPR-ised world look like? 1:16:00
wn.com/Splicing And Dicing Dna Genome Engineering And The Crispr Revolution
CRISPR: It’s the powerful gene editing technology transforming biomedical research. Fast, cheap and easy to use, it allows scientists to rewrite the DNA in just about any organism—including humans—with tests on human embryos already underway. The technique’s potential to radically reshape everything from disease prevention to the future of human evolution has driven explosive progress and heated debate. Join the world’s CRISPR pioneers to learn about the enormous possibilities and ethical challenges as we stand on the threshold of a brave new world of manipulating life’s fundamental code.
Subscribe to our YouTube Channel for all the latest from WSF.
Visit our Website: http://www.worldsciencefestival.com/
Like us on Facebook: https://www.facebook.com/worldsciencefestival
Follow us on twitter: https://twitter.com/WorldSciFest
Original Program Date: June 3 2016
MODERATOR: Richard Besser
PARTICIPANTS: George Church, Luke Dow, Josephine Johnston, Ben Matthews, Harry Ostrer, Noel Sauer
What is CRISPR? 00:05
Introduction by Richard Besser 3:58
Participant Introductions. 5:02
What is so powerful about CRISPR? 7:25
How is CRISPR is used? 13:00
How will CRISPR help eliminate Zika Virus? 20:45
Modifying 60 genes at once in a pig. 26:02
What are potential agricultural advantages from CRISPR? 28:44
If you have eaten CRISPR cells? 35:00
Using a gene drives to eliminate virus? 37:40
Creating an off switch for CRISPR 40:27
How is it ethical to not rid the world of malaria? 42:55
What is the difference between editing a germ line and editing a cancer cell? 48:27
Why would the first CRISPR baby create backlash? 58:48
How do we regular CRISPR used in military applications? 1:06:33
What is the regulation to be expected from CRISPR? 1:13:09
What does a CRISPR-ised world look like? 1:16:00
- published: 09 Aug 2016
- views: 105058
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16:04
Genetic Engineering Will Change Everything Forever – CRISPR
Designer babies, the end of diseases, genetically modified humans that never age. Outrageo...
published: 10 Aug 2016
Genetic Engineering Will Change Everything Forever – CRISPR
Genetic Engineering Will Change Everything Forever – CRISPR
- Report rights infringement
- published: 10 Aug 2016
- views: 4059933
7:21
What is CRISPR?
In this video Paul Andersen explains how the CRISPR/Cas immune system was identified in ba...
published: 18 Feb 2016
What is CRISPR?
What is CRISPR?
- Report rights infringement
- published: 18 Feb 2016
- views: 179221
8:39
CRISPR: A Gene-Editing Superpower
Any molecular biologist will tell you that genetic engineering is tricky. But up until rec...
published: 31 Aug 2016
CRISPR: A Gene-Editing Superpower
CRISPR: A Gene-Editing Superpower
- Report rights infringement
- published: 31 Aug 2016
- views: 314548
15:54
How CRISPR lets us edit our DNA | Jennifer Doudna
Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, ...
published: 12 Nov 2015
How CRISPR lets us edit our DNA | Jennifer Doudna
How CRISPR lets us edit our DNA | Jennifer Doudna
- Report rights infringement
- published: 12 Nov 2015
- views: 230069
4:13
Genome Editing with CRISPR-Cas9
This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technolo...
published: 05 Nov 2014
Genome Editing with CRISPR-Cas9
Genome Editing with CRISPR-Cas9
- Report rights infringement
- published: 05 Nov 2014
- views: 804766
9:54
What you need to know about CRISPR | Ellen Jorgensen
Should we bring back the wooly mammoth? Or edit a human embryo? Or wipe out an entire spec...
published: 24 Oct 2016
What you need to know about CRISPR | Ellen Jorgensen
What you need to know about CRISPR | Ellen Jorgensen
- Report rights infringement
- published: 24 Oct 2016
- views: 66322
9:58
The $140 Mail-Order CRISPR Kit: Is Unregulated Biohacking the Future of Science?
What happens when you democratize science and give anyone the ability to edit DNA?
Subscr...
published: 20 Jun 2016
The $140 Mail-Order CRISPR Kit: Is Unregulated Biohacking the Future of Science?
The $140 Mail-Order CRISPR Kit: Is Unregulated Biohacking the Future of Science?
- Report rights infringement
- published: 20 Jun 2016
- views: 31948
16:42
Jennifer Doudna (UC Berkeley / HHMI): Genome Engineering with CRISPR-Cas9
http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-b...
published: 23 Mar 2015
Jennifer Doudna (UC Berkeley / HHMI): Genome Engineering with CRISPR-Cas9
Jennifer Doudna (UC Berkeley / HHMI): Genome Engineering with CRISPR-Cas9
- Report rights infringement
- published: 23 Mar 2015
- views: 240761
4:11
What is CRISPR & How Could It Edit Your DNA?
Gene-editing tool CRISPR is everywhere in the news, but what is it and could it eliminate ...
published: 15 Jan 2016
What is CRISPR & How Could It Edit Your DNA?
What is CRISPR & How Could It Edit Your DNA?
- Report rights infringement
- published: 15 Jan 2016
- views: 93036
84:26
Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution
CRISPR: It’s the powerful gene editing technology transforming biomedical research. Fast, ...
published: 09 Aug 2016
Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution
Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution
- Report rights infringement
- published: 09 Aug 2016
- views: 105058
Genetic Engineering Will Change Everything Forever...
What is CRISPR?...
CRISPR: A Gene-Editing Superpower...
How CRISPR lets us edit our DNA | Jennifer Doudna...
Genome Editing with CRISPR-Cas9...
What you need to know about CRISPR | Ellen Jorgens...
The $140 Mail-Order CRISPR Kit: Is Unregulated Bio...
Jennifer Doudna (UC Berkeley / HHMI): Genome Engin...
What is CRISPR & How Could It Edit Your DNA?...
Splicing and Dicing DNA: Genome Engineering and th...
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Lyrics list:lyrics
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I Don't Think So, Gracia Baur
-
This Veil, Cory Sipper
I Don't Think So
I don't think so
Lights out, bad deal, you don't know how I feel
That's right, get real, don't under estimate me now
Your sick ideals don't have no part in me
Get lost, be gone, you hope that we'll go on
But I don't think so
You want me to be your bitch in bed
But I don't think so
You want me to love you 'til I'm dead
But I don't think so
You want me to make your food, clean up your mess
But I don't think so
This will only happen in your head
Cause I don't think so
Tough luck, you loose, I won't play by your rules
Too much, too soon, don't bother me with your do's and don't's
You're stuck, confused and ancient minded too
You pushed too far, now I got news for you
I don't think so
You want me to be your bitch in bed
But I don't think so
You want me to love you 'til I'm dead
But I don't think so
You want me to make your food, clean up your mess
But I don't think so
This will only happen in your head
Cause I don't think so
You want me to love you 'til I'm dead
This will only happen in your head
W hy do you mess up what we have
I don't think so
You want me to be your bitch in bed
But I don't think so
You want me to love you 'til I'm dead
But I don't think so
You want me to make your food, clean up your mess
But I don't think so
This will only happen in your head
Cause I don't think so
You want me to be your bitch in bed
But I don't think so
You want me to love you 'til I'm dead
But I don't think so
You want me to make your food, clean up your mess
But I don't think so
This will only happen in your head
Cause I don't think so
back
Donald Trump reacts as protests against election victory surge in cities across US for second night
Edit The Independent 11 Nov 2016
President-elect Donald Trump fired back on social media after demonstrators in both red and blue states hit the streets for another round of protests, showing outrage over the Republican's unexpected win ... Late Thursday night, Trump went on Twitter to take on the protesters....
back
Voter suppression laws likely tipped the scales for Trump, civil rights groups say
Edit The Miami Herald 10 Nov 2016
Civil rights groups say a tangle of Republican-backed “voter suppression” laws enacted since 2010 probably helped tip the scale for Republican nominee Donald Trump in some closely contested states on election night ... Alabama, Arizona, Indiana, Kansas, Mississippi, Nebraska, New Hampshire, Ohio, Rhode Island, South Carolina, Tennessee, Texas, Virginia and Wisconsin ... minorities, the poor, college students and other young voters. ... ....
back
'We Will Continue To Resist Trump and Empire' Declares Green Party’s Jill Stein
Edit WorldNews.com 11 Nov 2016
Article by WN.com Correspondent Dallas DarlingSince the Green Party’s Jill Stein believes each concession we make is accompanied by an inner resignation of which we are not immediately conscious of, after the election she and the Green Party declared they could not and would not concede to the President-elect ... Consequently, polls did show most voters were motivated by fear of the other candidate and not support for their candidate....
back
Nuclear weapons: how foreign hotspots could test Trump's finger on the trigger
Edit The Guardian 11 Nov 2016
From North Korea to Iran to Russia, a president-elect with civilisation-ending weaponry at his fingertips will face an in-tray of potential international crises. On Donald Trump’s first day in office he will be handed the “nuclear biscuit” – a small card with the codes he would need to talk to the Pentagon war room to verify his identity in the event of a national security crisis ... Read more ... He’s not competent ... North Korea ... Russia ... ....
back
Islamic State executes scores, stockpiles chemicals in Mosul: U.N.
Edit Yahoo Daily News 11 Nov 2016
By Tom Miles and Stephanie Nebehay. GENEVA (Reuters) - Islamic State fighters have executed scores more people around the northern Iraqi city of Mosul this week and are reported to be stockpiling dangerous chemicals in civilian areas, the U.N. human rights office said on Friday. A mass grave with over 100 bodies found in the town of Hammam al-Alil was one of several Islamic State killing grounds, spokeswoman Ravina Shamdasani said ... ....
Merck Wins R&D; 100 Award for Top Invention (Merck KGaA)
Edit Public Technologies 11 Nov 2016
Merck KGaA) Sanger Arrayed Lentiviral CRISPR Libraries wins in Analytical/Test category. Darmstadt, Germany, November 11, 2016 - Merck, a leading science and technology company, received a prestigious R&D 100 Award for its Sanger Arrayed Lentiviral CRISPR Libraries-the first of its kind CRISPR libraries ... Merck'sSanger Arrayed Lentiviral CRISPR Librarieswon in the Analytical/Test category....
MilliporeSigma Wins R&D; 100 Award for Top Invention
Edit PR Newswire 11 Nov 2016
- Sanger Arrayed Lentiviral CRISPR Libraries wins in Analytical/Test category BILLERICA, Mass., Nov. 11, 2016 /PRNewswire/ -- MilliporeSigma has received a prestigious R&D; 100 Award for its Sanger Arrayed Lentiviral CRISPR Libraries—the first of its kind CRISPR libraries. R&D; ... ....
Merck Wins R&D; 100 Award for Top Invention
Edit PR Newswire 11 Nov 2016
DARMSTADT, Germany, Nov. 11, 2016 /PRNewswire/ -- Merck, a leading science and technology company, received a prestigious R&D; 100 Award for its Sanger Arrayed Lentiviral CRISPR Libraries—the first of its kind CRISPR libraries. R&D; Magazine announced the awards at its 54th Annual ... ....
Merck gewinnt R&D; 100 Award für führende Innovationen ausgezeichnet
Edit PR Newswire 11 Nov 2016
-- Sanger Arrayed Lentiviral CRISPR Libraries ausgezeichnet in Kategorie Analyse/Tests DARMSTADT, 11. November 2016 /PRNewswire/ -- Merck, ein führendes Wissenschafts- und Technologieunternehmen, wurde heute mit dem prestigeträchtigen „R&D; 100 Award" ausgezeichnet. für die Sanger ... ....
Merck recebe o prêmio R&D; 100 Award por sua grande invenção
Edit PR Newswire 11 Nov 2016
- As bibliotecas lentivirais de CRISPR organizadas pelo Sanger vencem na categoria Análise/Teste DARMSTADT, Alemanha, 11 de novembro de 2016 /PRNewswire/ -- A Merck, empresa líder de ciência e tecnologia, recebeu o prestigiado prêmio R&D; 100 Award por suas bibliotecas lentivirais ... ....
New Gene-Editing Technology Cures Genetic Blood Disorder in Mice (Carnegie Mellon University)
Edit Public Technologies 11 Nov 2016
Unlike the popular CRISPR gene-editing technique, the new technology can be administered to living animals and significantly decreases unwanted, off-target gene mutations ... This has not been achieved with CRISPR,' said Danith Ly, professor of chemistry in Carnegie Mellon's Mellon College of Science and an expert in PNA chemistry....
OUR HEALTHY FUTURE: How technology and public health efforts will transform and extend people's lives in the next ten years
Edit Business Insider 11 Nov 2016
One of the great stories of the 20th Century was the dramatic extension of the human lifespan ... In 1900, . In 1950 it was 48. In 2010 it was 70. So the question is. What's next? ... Welcome to the next 10 years of human longevity ... CRISPR, a cheap and effective tool to line-editing genomes, is revolutionizing biology. Research into genetic therapy protocols is already well underway — and the first human CRISPR trial began in China this year ... ....
Cloud technology giving us a “CRISPR” view to help cure disease (CSIRO - Commonwealth Scientific and Industrial Research Organisation)
Edit Public Technologies 10 Nov 2016
This new method, called CRISPR-Cas9, can be programmed to recognise and edit specific locations in the genome by pattern-matching unique sequences of DNA ... This new application in human health requires an increase in robustness and efficiency of CRISPR-Cas9 design in order to meet the time constraints of clinical care. To address this, we developed a software tool called GT-Scan2 that helps choose the optimal CRISPR target site....
Alberta RNA Research and Training Institute welcomes Gairdner Award winner for public lectures (University of Lethbridge)
Edit Public Technologies 10 Nov 2016
Rodolphe Barrangou is renowned for his work in establishing and characterizing the CRISPR-Cas bacterial immune defense system ... Barrangou, an Associate Professor in the Department of Food, Bioprocessing and Nutrition Sciences at North Carolina State University, is renowned for his work in establishing and characterizing the CRISPR-Cas bacterial immune defense system....
Fall Major Production explores the ethics of genetic manipulation (McMaster University)
Edit Public Technologies 10 Nov 2016
(Source. McMaster University). Genetic science will soon allow us to eradicate diseases and congenital conditions. But should we use this capability on humans? What genes, if any, should be erased from the human race? ... The play's title, CAS9, refers to Crispr cas9, a new genetic technology that allows researchers to edit out a single gene from a string of DNA and replace it with another ... The journey has been deeply rewarding.' ... (noodl....
New boost for research on degenerative retina dystrophies (Universitat de Barcelona)
Edit Public Technologies 10 Nov 2016
(Source ... 10/11/2016 ... The new scientific project entitled 'Construcción de un nuevo modelo animal de retinosis pigmentaria y estudio de su utilidad para ensayos de terapias neuroprotectoras' (Creation of a new animal model of pigmentary retinosis and study of its use in neuroprotective therapy tests), partially financially supported by ONCE, aims to create a mice model of DR through the CRISPR/Cas9 genome editing system with Cerkl gene....
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