2-Mercaptoethanol

2-Mercaptoethanol (also β-mercaptoethanol, BME, 2BME, 2-ME or β-met) is the chemical compound with the formula HOCH₂CH₂SH. ME or βME, as it is commonly abbreviated, is used to reduce disulfide bonds and can act as a biological antioxidant by scavenging hydroxyl radicals (amongst others). It is widely used because the hydroxyl group confers solubility in water and lowers the volatility. Due to its diminished vapor pressure, its odor, while unpleasant, is less objectionable than related thiols.

Preparation

2-Mercaptoethanol may be prepared by the action of hydrogen sulfide on ethylene oxide:

Reactions

2-Mercaptoethanol reacts with aldehydes and ketones to give the corresponding oxathiolanes. This makes 2-mercaptoethanol useful as a protecting group.

Applications

Reducing proteins

Some proteins can be denatured by 2-mercaptoethanol, which cleaves the disulfide bonds that may form between thiol groups of cysteine residues. In the case of excess 2-mercaptoethanol, the following equilibrium is shifted to the right:

Met 3

Met 3 is part of Metropolitan Miami, a complex of four skyscrapers in the central business district of Downtown Miami, Florida, United States. Met 3 was proposed as the tallest of the four towers, was originally under construction during the 2000s real estate bubble and planned for completion in 2011. However, the project was put on hold. By 2011 construction had never gotten past site preparation, until the new design finally began construction in December 2011.

If completed as originally proposed, the 828 feet Met 3 would have been the tallest building in Miami and the state of Florida. It would have contained 76 floors, which would have also made it the tallest building in the United States south of New York City in terms of floor count. In total height, it would have also been the tallest residential building south of New York, consisting of residential condominium units, passing the Four Seasons Hotel Miami, which holds that distinction currently.

History

The Metropolitan Miami project gained attention due to NBA star Shaquille O'Neal's involvement in the project. He formed the O'Neal Group, a building-development company. The Metropolitan Miami project is the group's first.

Last (Unthanks album)

Last, the fourth album by English folk group The Unthanks, was released on 14 March 2011. It reached number 40 in the UK Albums Chart and was well received by the critics, receiving a five-starred review in the Sunday Express and four-starred reviews in The Guardian and The Daily Telegraph.

Songs

As well as traditional material, the album included a song written by band member Adrian McNally ("Last"), and versions of songs by Jon Redfern ("Give Away Your Heart"), Tom Waits and Kathleen Brennan ("No One Knows I'm Gone"), King Crimson ("Starless") and Alex Glasgow ("Close the Coalhouse Door"). "Last" was also issued as a single, edited for radio play; this was released on 13 June 2011.

Production and release

The album was produced by Adrian McNally; he and Thom Lewis were the sound engineers. The album was mastered by Denis Blackham and was released in the UK by Rabble Rouser Music on 14 March 2011. It was released in Europe by Rough Trade Records and in Australia on the Fuse Music Group label.

Last (TV series)

Last (Hangul: 라스트; RR: Laseuteu) is a 2015 South Korean television series based on the webtoon of the same name by Kang Hyung-kyu. Starring Yoon Kye-sang and Lee Beom-soo, it aired on jTBC on Fridays and Saturdays at 20:40 from July 24 to September 12, 2015 for 16 episodes.

Plot

Jang Tae-ho is a successful fund manager whose seemingly fool-proof financial deal goes horribly awry, leading to a loss of ₩350 million and his business partner's death. In desperate straits, Tae-ho goes on the run from loan shark gangsters and descends into the underbelly of Seoul. He discovers a secret society of homeless people living inside Seoul Station, one that has its own strict hierarchy and rules. Tae-ho vows to find out what went wrong with his deal, claw himself up from rock bottom, and get his life back.

Cast

Last (Uverworld album)

LAST is the 5th full album released by Japanese band Uverworld as well as the follow-up to their fourth album, Awakeve. It was released on April 14, 2010. A limited pressing of the album was also released on the same day which includes a DVD containing music videos of 99/100 Damashi no Tetsu (99/100騙しの哲?), Go-On and Kanashimi wa Kitto (哀しみはきっと?) as well as a video of the filming process for their 3 music videos and a bonus clip "Special Track 09.12.25: Turn Around with Gold" which is a Gold special video.

The album was one of the highly anticipated album and was ranked #2 at the Ninki Chart and was charted at #2 for Oricon Weekly Ranking.

The title means the present time's highest, newest and the ultimate album.

Track listing

Personnel

References

Coyote (comics)

Coyote is an American comic book series created by Steve Englehart and Marshall Rogers.

Publication history

The characters first appeared in Eclipse Magazine #2-8. It would later be reprinted in a color trade paperback, I Am Coyote.

Afterwards, a new comic book series started at Marvel Comics Epic Comics line, that ran 16 issues. It was notable for the first published work of Todd McFarlane. According to Epic editor-in-chief Archie Goodwin, artist Steve Leialoha's departure after issue #2 caused deadline problems that the series never fully recovered from, leading to its early cancellation.

Collected editions

The original Eclipse & Epic series has been reprinted in a series of collections from Image Comics:

Coyote (song)

"Coyote" is the opening song from Joni Mitchell's 1976 album Hejira and also the album's first single.

Though the song had been introduced (in embryonic form) on the tour to support 1975's The Hissing of Summer Lawns, "Coyote" was a significant musical departure: where Hissing was ornate with pianos, layered vocals and percussion, "Coyote" was stripped down to electric and acoustic guitars and a fretless bass guitar played by legendary virtuoso Jaco Pastorius. In a sense, this was similar to Mitchell's early albums, but the sound was extremely spacious, even repetitive, with the verses made much longer and more like a long story. Thus, although this is one of the faster-tempo songs on Hejira, it still lasts for an even five minutes. Mitchell's guitar itself was in an unusual (low to high) C-G-D-F-C-E tuning (the same as in the song "Ladies of the Canyon") - presumably a type of open tuning designed to play a seventh, ninth, or even eleventh chord.

Lyrically, "Coyote" is concerned with the difficulty of establishing any sort of connection with people who come from "different sets of circumstance" (as the song has it). In particular it describes an encounter (which turns into a one-night stand) between the narrator (possibly meant to be Mitchell herself as there is a reference in the lyrics to her coming home from the studio) and "Coyote", a ranch worker. In Chris O'Dell's 2009 autobiography Miss O'Dell she details an affair she had with married playwright Sam Shepard and states that Shepard then cheated on her with Joni Mitchell. O'Dell claims that "Coyote" is written about Sam Shepard. Coyote represents nature contrasted with the narrator's big city (presumably LA) life where "pills and powders" are necessary to "get them through this passion play". The aforementioned line is also a reference to Bob Dylan's Rolling Thunder Revue, which Mitchell was a part of in the fall of 1975.