- published: 12 Jan 2016
- views: 53645
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.
PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. It plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.
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How are CDs/DVDs Manufactured? From Season 1, Episode 2 of How It's Made.
The 2014 USDGC Champion, Will Schusterick from Team Prodigy, teaches how to maximize your distance and perfect your throwing technique during a free clinic presented by Infinite Discs. Be sure to check out more of Infinite Discs Pro Clinics and disc reviews at http://www.infinitediscs.com Filmed and edited by Cassidy Houdeshel
In this animation we explain what a hernia is and that this condition can involve discs in the spine. Although in many cases herniated discs recover without intervention, sometimes surgery is necessary. In the animation we explain the different types of surgical treatment of a herniated disc, such as an open discectomy, a laminotomy and a laminectomy. Healthchannel makes complex medical information easy to understand. With 2D and 3D animations checked by medical specialists, we give information on certain diseases: what is it, what are the causes and how is it treated? Subscribe to our Youtube channel and learn more about your health! Healthchannel Youtube channel: http://www.youtube.com/cherishyourhealthtv Subscribe here: http://www.youtube.com/subscription_center?add_user=cherishyourh...
Video game discs for PC, Sony, and Nintendo consoles have a bevy of history and trivia facts. Let's talk about 'em! ★ Gameranx Facebook: https://www.facebook.com/gameranx ★Subscribe for more: https://www.youtube.com/gameranxTV --Modded Consoles by Vadu Amka: http://www.vaduamka.com/
This video explains how discs work. It's designed for beginners who have no clue why discs fly the way they don't want them to. The plan is to help reduce frustration, play more better and have more fun. Guardians of Recreation
Brake pads consist of a backing plate and friction material. It is the friction material that comes into contact with the brake disc. Overtime the friction material wears down and your brakes become less effective at stopping your vehicle. The manufacturer of your vehicle will specify a minimum thickness of the friction material before the brake pads need to be replaced.When checking your brake pads, you should look at the inner and outer brake pads as they can wear at different rates. If your vehicle is fitted with alloy wheels looking at the thickness of the outer pad is not enough.Brake discs are made of cast iron. Like brake pads they can wear over time. Depending on your driving style, brake discs have a longer service life than the pads and do not require replacement every time pads ...
One of the common causes of a PS4 that won't read discs. In this video we do a complete repair of the optical drive rollers and white connecting rod. I share tips and tricks as I go. -Disc Drive Repair: http://www.tronicsfix.com/ps4-disc-drive-repair.html -Our Facebook Page: https://www.facebook.com/TheRefurbishedElectronicsDepot/
Complete guide to the TURN (high-speed stability) disc golf disc rating, including how Turn affects flight, factors impacting Turn, and how to choose between Overstable and Understable discs. For more information, visit our website at http://www.bestdiscgolfdiscs.com/overstable-understable-discs-how-to-choose-turn-rating/
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