Structural and cross-linking analyses provide deeper insight into Zuo1's dual interactions with the ribosomal 60S and 40S subunits and indicate how Zuo1 may coordinate cotranslational protein folding and translation.

Structural, biochemical and functional analyses elucidate the mechanisms by which mutations in the TBC1D24 gene interfere with protein function, thus causing early-onset epilepsy and DOORS syndrome.

Cryo-EM and mass spectrometry analyses of the spike glycoprotein trimer from coronavirus HcoV-NL63 reveal an extensive glycan shield that covers the protein surface, including an epitope targeted by neutralizing antibodies against several …

In this Review, the authors discuss recent advances in understanding how post-translational modifications of the RNA polymerase II C-terminal domain (CTD) regulate transcription and RNA processing events and control gene expression.

In this Review, the authors discuss recent advances in understanding how post-translational modifications of the RNA polymerase II C-terminal domain (CTD) regulate transcription and RNA processing events and control gene expression.

Bacterial multidrug efflux transporters (MATEs) couple drug export to Na⁺ or H⁺ influx. A new crystal structure of the H⁺-coupled DinF transporter from Bacillus halodurans reveals differences in the substrate-binding sites and transport mechanisms …

A cryo-EM structure of the human 26S proteasome in a resting state at an average resolution of 3.5 Å reveals details in the interactions between subunits. An additional structure of the proteasome with USP14 bound suggests a mechanism for its …

The crystal structure of the C-terminal region of Zika virus nonstructural protein 1 (NS1) reveals a fold similar to those of other flaviviruses (dengue and West Nile viruses) but different surface electrostatic features.

The inability of A-form RNA to form Hoogsteen base pairs provides a mechanism for how post-transcriptional modifications can disrupt RNA structure and might help explain why DNA is the molecular choice for storing genetic information.