JWH-200
Из Википедије, слободне енциклопедије
 |
|
| Klinički podaci | |
|---|---|
| AHFS/Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 103610-04-4 |
| ATC kod | nije dodeljen |
| PubChem[1][2] | 10045570 |
| Hemijski podaci | |
| Formula | C25H24N2O2 |
| Mol. masa | 384,470 |
| SMILES | eMolekuli & PubHem |
|
|
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
JWH-200 je organsko jedinjenje, koje sadrži 25 atoma ugljenika i ima molekulsku masu od 384,470 Da.
Osobine[уреди]
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 3 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 5 |
| Particioni koeficijent[3] (ALogP) | 4,5 |
| Rastvorljivost[4] (logS, log(mol/L)) | -6,6 |
| Polarna površina[5] (PSA, Å2) | 34,5 |
Reference[уреди]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. doi:10.1016/S1574-1400(08)00012-1.
- ↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. doi:10.1021/jp980230o.
- ↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. doi:10.1021/ci000392t. PMID 11749573.
- ↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. doi:10.1021/jm000942e. PMID 11020286.
Literatura[уреди]
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 ed.). New York: McGraw-Hill. doi:10.1036/0071422803. ISBN 0071354697.
- Thomas L. Lemke, David A. Williams, ed. (2007). Foye's Principles of Medicinal Chemistry (6 ed.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
