- published: 26 Jun 2018
- views: 174052
-
remove the playlistInositol Trisphosphate Receptor
- remove the playlistInositol Trisphosphate Receptor
Inositol trisphosphate receptor
Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory. Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca2+ from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca2+ signals characterized by complex patterns relative to both space and time. For example, Ca2+ waves and oscillations. The InsP3 receptor was first purified from rat cerebellum by neuroscientists Surachai Supattapone and Solomon Snyder at Johns Hopkins University School of Medicine.
Distribution
It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the InsP3Rs are found in the cell integrated into the endoplasmic reticulum.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Inositol_trisphosphate_receptor
Podcasts:
-
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets. Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated. I hope you find this video helpful. If you do, please like and subscribe for more videos like this one....
published: 26 Jun 2018 -
IP3 DAG Calcium Pathway
IP3-mediated signal transduction pathways First messengers are extracellular signaling molecules, such as hormones or neurotransmitters. In response to exposure to these first messengers, intracellular signaling molecules called second messengers are released by the cell. Two such second messengers are IP3 and DAG. Calcium is also an important second messenger. Transient increases in cytoplasmic Ca2+ levels are caused by the binding of some hormones and signal molecules, and this can send important intracellular signals, by activating calcium-binding proteins that then perform various functions. Note that cytosolic increases in calcium concentration can occur in two ways. There are reservoirs of calcium that can be opened within the cell by the second messenger IP3 – the endoplasmic retic...
published: 13 Oct 2019 -
Insights into inositol 1,4,5-trisphosphate receptor structure and function
Webcast of the presentation entitled 'Insights into inositol 1,4,5-trisphosphate receptor structure and function from playing LEGO with receptor subunits ' given by David Yule (University of Rochester, USA). Presented at the Biochemical Society focus meeting 'Calcium Signalling: The Next Generation' held at Charles Darwin House, United Kingdom at 9 - 10 September 2014.
published: 22 Oct 2014 -
Inositol triphosphate (IP3) | Calcium release
GPCRs step by step in following videos GPCRs (G protein linked cell signaling) https://youtu.be/GSjVKVGK_1o GPCRs (Activation of G protein receptor) https://youtu.be/Le_f5cxpD4w GPCRs (phospholipase C activation IP3 & DAG, Diacyl Glycerol) https://youtu.be/2bbBrpgeheY GPCRs - (Inositol triphosphate (IP3) Calcium release) https://youtu.be/lsYBeFqEwzk GPCRs- (Di acyl glycerol (DAG) activates protein Kinase C (PKC) https://youtu.be/larIxw_9ePU GPCRs- (Adenyl Cyclase and cAMP) https://youtu.be/0nA2xhNiAow GPCRs- (Protein kinase A activation by cAMP ) https://youtu.be/NaOBRvAFiJQ #BiotechReview #GPCRs #GProtein #CellSignaling #SignalTransduction #IP3
published: 08 Dec 2011 -
What is the role of inositol triphosphate?
published: 12 Oct 2020 -
Inositol 1,4,5-Trisphosphate Receptor (IP3R) Model in a Dendritic Spine
This video visualizes the IP3 receptor model in a realistic spine reconstruction, simulated using STEPS (http://steps.sourceforge.net/) simulator. It demonstrates the activation of IP3 receptors on the Endoplasmic Reticulum (ER) membrane by cytosolic Ca2+, leading to the release of Ca2+ from the ER and the rapid increase of cytosolic Ca2+ concentration, which in turn increases the number of open-state IP3 receptors. Published in: W. Chen and E. De Schutter: Python-based geometry preparation and simulation visualization toolkits for STEPS. Frontiers in Neuroinformatics 8: 37 (2014). https://www.frontiersin.org/articles/10.3389/fninf.2014.00037/full.
published: 09 Jun 2020 -
Caged Inositol Trisphosphate Part 1
In this video we discuss what caged inositol trisphosphate is and c=give an example of an experimental construct which makes use of it.
published: 05 Jan 2015 -
Inositol triphosphate and Diacylglycerol Pathway by Dr. Nitin Nema
It is one of the most widespread pathways of intracellular signaling which is derived from the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 forms different second messenger system which ultimately produces biological response through the mobilization of stored energy in the cell via Calcium release mechanism.#Inositoltriphosphate#GPCR#Diacylglycerol#
published: 04 Aug 2019 -
Inositol 1,4,5-trisphosphate receptor (Anti-ITPR1)(Anti-Sj) in Purkinje cells of the cerebellum.
For more videos abut immunofluorescence patterns click 👇👇👇 Immunofluorescence: https://www.youtube.com/playlist?list=PLRDmErrHTaZ36bY-Sx7cu7Y59iMb2AtSc
published: 23 May 2022 -
INOSITOL TRISPHOSPHATE (IP3) & DIACYLGLYCEROL (DAG) AS SECOND MESSENGERS
release of inositol triphosphate (IP3) and diacylglycerol (DAG) as second messengers. Binding of ligand to G protein-coupled receptor activates phospholipase C (PLC)β. Alternatively, activation of receptors with intracellular tyrosine kinase domains can activate PLCγ. The resulting hydrolysis of phosphatidylinositol 4,5-diphosphate (PIP2) produces IP3, which releases Ca2+ from the endoplasmic reticulum (ER), and DAG, which activates protein kinase C (PKC). CaBP, Ca2+-binding proteins, and physiologic response
published: 15 Mar 2019
developed with YouTube
5:42
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
- Order: Reorder
- Duration: 5:42
- Uploaded Date: 26 Jun 2018
- views: 174052
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregul...
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets.
Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Microphone I use to record these lessons
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Stethoscope I use in my clinical work
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Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
----------------------------------------------------------------------------------------------------
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe! JJ
----------------------------------------------------------------------------------------------------
DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
https://wn.com/Inositol_Triphosphate_(Ip3)_And_Calcium_Signaling_Pathway_|_Second_Messenger_System
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets.
Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Microphone I use to record these lessons
https://www.amazon.com/dp/B00N1YPXW2/?tag=aiponsite-20&linkCode;=ic5&ascsubtag;=amzn1.idea.1K2H9Z4RF77DB&creativeASIN;=B00N1YPXW2&ref;=exp_jjmedicine_dp_vv_d
Stethoscope I use in my clinical work
https://www.amazon.com/dp/B01M0I4KOZ/?tag=aiponsite-20&linkCode;=ic5&ascsubtag;=amzn1.idea.1K2H9Z4RF77DB&creativeASIN;=B01M0I4KOZ&ref;=exp_jjmedicine_dp_vv_d
Support future lessons and lectures ➜ https://www.patreon.com/jjmedicine
Start your own website with BlueHost ➜ https://www.bluehost.com/track/jjmedicine/
Check out the best tool to help grow your YouTube channel (it’s helped me!)
https://www.tubebuddy.com/jjmedicine
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
----------------------------------------------------------------------------------------------------
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe! JJ
----------------------------------------------------------------------------------------------------
DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
3:27
IP3 DAG Calcium Pathway
- Order: Reorder
- Duration: 3:27
- Uploaded Date: 13 Oct 2019
- views: 182029
IP3-mediated signal transduction pathways
First messengers are extracellular signaling molecules, such as hormones or neurotransmitters. In response to exposure...
IP3-mediated signal transduction pathways
First messengers are extracellular signaling molecules, such as hormones or neurotransmitters. In response to exposure to these first messengers, intracellular signaling molecules called second messengers are released by the cell. Two such second messengers are IP3 and DAG.
Calcium is also an important second messenger. Transient increases in cytoplasmic Ca2+ levels are caused by the binding of some hormones and signal molecules, and this can send important intracellular signals, by activating calcium-binding proteins that then perform various functions. Note that cytosolic increases in calcium concentration can occur in two ways. There are reservoirs of calcium that can be opened within the cell by the second messenger IP3 – the endoplasmic reticulum and calciosomes. Otherwise, cyclic AMP can activate the opening of calcium channels in the plasma membrane so that extracellular calcium can rush in.
G-protein-coupled receptors, or GPCRs, are integral membrane proteins, meaning that they are locked into the cell membrane. They are locked in via 7 transmembrane α-helical segments. GPCRs recognize ligands through an extracellular recognition site. They also have an intracellular recognition site for a G protein. When a ligand binds the extracellular recognition site of a GPCR, this induces a conformational change, activating the G-Protein.
There are different kinds of G proteins, sometimes also called membrane-associated heterotrimeric G proteins. Gs activates adenylyl cyclase. Gi inhibits adenylyl cyclase.
Gq has three subunits – α, β, and γ. A conformational change in the GPCR activates the G protein. When this happens, the GDP on the Gα subunit gets replaced by GTP. This drives dissociation of the Gα subunit from the Gβγ complex. The now free Gα subunit can activate Phospholipase C-β.
Phosphatidylinositol-4-P (PIP) and phosphatidylinositol-4,5-biphosphate (PIP2) are produced through successive phorphorylations of phosphatidylinositol (PI). Once it is activated by a G-protein, Phospholipase C-β can break down PIP2.
PIP2 is hydrolyzed by phospholipase-C to produce inositol-1,4,5-triphosphate (IP3) and diacylglycerol (DAG), both of which act as second messengers. IP3 is hydrophilic, and diffuses into the cell, while DAG is lipophilic, and hence remains in the cell membrane. IP3 binds to calcium channel on endoplasmic reticulum (or the sarcoplasmic reticulum in the case of muscle cells) and allows release of calcium from the endoplasmic reticulum lumen. DAG, with the help of the calcium released from the endoplasmic reticulum, activates the calcium-dependent Protein Kinase C. Once activated, protein kinase C adds phosphates to target proteins and causes cellular responses.
https://wn.com/Ip3_Dag_Calcium_Pathway
IP3-mediated signal transduction pathways
First messengers are extracellular signaling molecules, such as hormones or neurotransmitters. In response to exposure to these first messengers, intracellular signaling molecules called second messengers are released by the cell. Two such second messengers are IP3 and DAG.
Calcium is also an important second messenger. Transient increases in cytoplasmic Ca2+ levels are caused by the binding of some hormones and signal molecules, and this can send important intracellular signals, by activating calcium-binding proteins that then perform various functions. Note that cytosolic increases in calcium concentration can occur in two ways. There are reservoirs of calcium that can be opened within the cell by the second messenger IP3 – the endoplasmic reticulum and calciosomes. Otherwise, cyclic AMP can activate the opening of calcium channels in the plasma membrane so that extracellular calcium can rush in.
G-protein-coupled receptors, or GPCRs, are integral membrane proteins, meaning that they are locked into the cell membrane. They are locked in via 7 transmembrane α-helical segments. GPCRs recognize ligands through an extracellular recognition site. They also have an intracellular recognition site for a G protein. When a ligand binds the extracellular recognition site of a GPCR, this induces a conformational change, activating the G-Protein.
There are different kinds of G proteins, sometimes also called membrane-associated heterotrimeric G proteins. Gs activates adenylyl cyclase. Gi inhibits adenylyl cyclase.
Gq has three subunits – α, β, and γ. A conformational change in the GPCR activates the G protein. When this happens, the GDP on the Gα subunit gets replaced by GTP. This drives dissociation of the Gα subunit from the Gβγ complex. The now free Gα subunit can activate Phospholipase C-β.
Phosphatidylinositol-4-P (PIP) and phosphatidylinositol-4,5-biphosphate (PIP2) are produced through successive phorphorylations of phosphatidylinositol (PI). Once it is activated by a G-protein, Phospholipase C-β can break down PIP2.
PIP2 is hydrolyzed by phospholipase-C to produce inositol-1,4,5-triphosphate (IP3) and diacylglycerol (DAG), both of which act as second messengers. IP3 is hydrophilic, and diffuses into the cell, while DAG is lipophilic, and hence remains in the cell membrane. IP3 binds to calcium channel on endoplasmic reticulum (or the sarcoplasmic reticulum in the case of muscle cells) and allows release of calcium from the endoplasmic reticulum lumen. DAG, with the help of the calcium released from the endoplasmic reticulum, activates the calcium-dependent Protein Kinase C. Once activated, protein kinase C adds phosphates to target proteins and causes cellular responses.
- published: 13 Oct 2019
- views: 182029
13:15
Insights into inositol 1,4,5-trisphosphate receptor structure and function
- Order: Reorder
- Duration: 13:15
- Uploaded Date: 22 Oct 2014
- views: 637
Webcast of the presentation entitled 'Insights into inositol 1,4,5-trisphosphate receptor structure and function from playing LEGO with receptor subunits ' give...
Webcast of the presentation entitled 'Insights into inositol 1,4,5-trisphosphate receptor structure and function from playing LEGO with receptor subunits ' given by David Yule (University of Rochester, USA). Presented at the Biochemical Society focus meeting 'Calcium Signalling: The Next Generation' held at Charles Darwin House, United Kingdom at 9 - 10 September 2014.
https://wn.com/Insights_Into_Inositol_1,4,5_Trisphosphate_Receptor_Structure_And_Function
Webcast of the presentation entitled 'Insights into inositol 1,4,5-trisphosphate receptor structure and function from playing LEGO with receptor subunits ' given by David Yule (University of Rochester, USA). Presented at the Biochemical Society focus meeting 'Calcium Signalling: The Next Generation' held at Charles Darwin House, United Kingdom at 9 - 10 September 2014.
- published: 22 Oct 2014
- views: 637
0:46
Inositol triphosphate (IP3) | Calcium release
- Order: Reorder
- Duration: 0:46
- Uploaded Date: 08 Dec 2011
- views: 44507
GPCRs step by step in following videos
GPCRs (G protein linked cell signaling)
https://youtu.be/GSjVKVGK_1o
GPCRs (Activation of G protein receptor)
https://you...
GPCRs step by step in following videos
GPCRs (G protein linked cell signaling)
https://youtu.be/GSjVKVGK_1o
GPCRs (Activation of G protein receptor)
https://youtu.be/Le_f5cxpD4w
GPCRs (phospholipase C activation IP3 & DAG, Diacyl Glycerol)
https://youtu.be/2bbBrpgeheY
GPCRs - (Inositol triphosphate (IP3) Calcium release)
https://youtu.be/lsYBeFqEwzk
GPCRs- (Di acyl glycerol (DAG) activates protein Kinase C (PKC)
https://youtu.be/larIxw_9ePU
GPCRs- (Adenyl Cyclase and cAMP)
https://youtu.be/0nA2xhNiAow
GPCRs- (Protein kinase A activation by cAMP )
https://youtu.be/NaOBRvAFiJQ
#BiotechReview #GPCRs #GProtein #CellSignaling #SignalTransduction #IP3
https://wn.com/Inositol_Triphosphate_(Ip3)_|_Calcium_Release
GPCRs step by step in following videos
GPCRs (G protein linked cell signaling)
https://youtu.be/GSjVKVGK_1o
GPCRs (Activation of G protein receptor)
https://youtu.be/Le_f5cxpD4w
GPCRs (phospholipase C activation IP3 & DAG, Diacyl Glycerol)
https://youtu.be/2bbBrpgeheY
GPCRs - (Inositol triphosphate (IP3) Calcium release)
https://youtu.be/lsYBeFqEwzk
GPCRs- (Di acyl glycerol (DAG) activates protein Kinase C (PKC)
https://youtu.be/larIxw_9ePU
GPCRs- (Adenyl Cyclase and cAMP)
https://youtu.be/0nA2xhNiAow
GPCRs- (Protein kinase A activation by cAMP )
https://youtu.be/NaOBRvAFiJQ
#BiotechReview #GPCRs #GProtein #CellSignaling #SignalTransduction #IP3
- published: 08 Dec 2011
- views: 44507
6:56
What is the role of inositol triphosphate?
- Order: Reorder
- Duration: 6:56
- Uploaded Date: 12 Oct 2020
- views: 650
- published: 12 Oct 2020
- views: 650
1:23
Inositol 1,4,5-Trisphosphate Receptor (IP3R) Model in a Dendritic Spine
- Order: Reorder
- Duration: 1:23
- Uploaded Date: 09 Jun 2020
- views: 120
This video visualizes the IP3 receptor model in a realistic spine reconstruction, simulated using STEPS (http://steps.sourceforge.net/) simulator. It demonstrat...
This video visualizes the IP3 receptor model in a realistic spine reconstruction, simulated using STEPS (http://steps.sourceforge.net/) simulator. It demonstrates the activation of IP3 receptors on the Endoplasmic Reticulum (ER) membrane by cytosolic Ca2+, leading to the release of Ca2+ from the ER and the rapid increase of cytosolic Ca2+ concentration, which in turn increases the number of open-state IP3 receptors.
Published in:
W. Chen and E. De Schutter: Python-based geometry preparation and simulation visualization toolkits for STEPS. Frontiers in Neuroinformatics 8: 37 (2014).
https://www.frontiersin.org/articles/10.3389/fninf.2014.00037/full.
https://wn.com/Inositol_1,4,5_Trisphosphate_Receptor_(Ip3R)_Model_In_A_Dendritic_Spine
This video visualizes the IP3 receptor model in a realistic spine reconstruction, simulated using STEPS (http://steps.sourceforge.net/) simulator. It demonstrates the activation of IP3 receptors on the Endoplasmic Reticulum (ER) membrane by cytosolic Ca2+, leading to the release of Ca2+ from the ER and the rapid increase of cytosolic Ca2+ concentration, which in turn increases the number of open-state IP3 receptors.
Published in:
W. Chen and E. De Schutter: Python-based geometry preparation and simulation visualization toolkits for STEPS. Frontiers in Neuroinformatics 8: 37 (2014).
https://www.frontiersin.org/articles/10.3389/fninf.2014.00037/full.
- published: 09 Jun 2020
- views: 120
19:44
Caged Inositol Trisphosphate Part 1
- Order: Reorder
- Duration: 19:44
- Uploaded Date: 05 Jan 2015
- views: 121
In this video we discuss what caged inositol trisphosphate is and c=give an example of an experimental construct which makes use of it.
In this video we discuss what caged inositol trisphosphate is and c=give an example of an experimental construct which makes use of it.
https://wn.com/Caged_Inositol_Trisphosphate_Part_1
In this video we discuss what caged inositol trisphosphate is and c=give an example of an experimental construct which makes use of it.
- published: 05 Jan 2015
- views: 121
6:52
Inositol triphosphate and Diacylglycerol Pathway by Dr. Nitin Nema
- Order: Reorder
- Duration: 6:52
- Uploaded Date: 04 Aug 2019
- views: 1097
It is one of the most widespread pathways of intracellular signaling which is derived from the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2...
It is one of the most widespread pathways of intracellular signaling which is derived from the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 forms different second messenger system which ultimately produces biological response through the mobilization of stored energy in the cell via Calcium release mechanism.#Inositoltriphosphate#GPCR#Diacylglycerol#
https://wn.com/Inositol_Triphosphate_And_Diacylglycerol_Pathway_By_Dr._Nitin_Nema
It is one of the most widespread pathways of intracellular signaling which is derived from the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 forms different second messenger system which ultimately produces biological response through the mobilization of stored energy in the cell via Calcium release mechanism.#Inositoltriphosphate#GPCR#Diacylglycerol#
- published: 04 Aug 2019
- views: 1097
0:09
Inositol 1,4,5-trisphosphate receptor (Anti-ITPR1)(Anti-Sj) in Purkinje cells of the cerebellum.
- Order: Reorder
- Duration: 0:09
- Uploaded Date: 23 May 2022
- views: 15
For more videos abut immunofluorescence patterns click 👇👇👇
Immunofluorescence: https://www.youtube.com/playlist?list=PLRDmErrHTaZ36bY-Sx7cu7Y59iMb2AtSc
For more videos abut immunofluorescence patterns click 👇👇👇
Immunofluorescence: https://www.youtube.com/playlist?list=PLRDmErrHTaZ36bY-Sx7cu7Y59iMb2AtSc
https://wn.com/Inositol_1,4,5_Trisphosphate_Receptor_(Anti_Itpr1)(Anti_Sj)_In_Purkinje_Cells_Of_The_Cerebellum.
For more videos abut immunofluorescence patterns click 👇👇👇
Immunofluorescence: https://www.youtube.com/playlist?list=PLRDmErrHTaZ36bY-Sx7cu7Y59iMb2AtSc
- published: 23 May 2022
- views: 15
10:35
INOSITOL TRISPHOSPHATE (IP3) & DIACYLGLYCEROL (DAG) AS SECOND MESSENGERS
- Order: Reorder
- Duration: 10:35
- Uploaded Date: 15 Mar 2019
- views: 892
release of inositol triphosphate (IP3) and diacylglycerol (DAG) as second messengers. Binding of ligand to G protein-coupled receptor activates phospholipase C ...
release of inositol triphosphate (IP3) and diacylglycerol (DAG) as second messengers. Binding of ligand to G protein-coupled receptor activates phospholipase C (PLC)β. Alternatively, activation of receptors with intracellular tyrosine kinase domains can activate PLCγ. The resulting hydrolysis of phosphatidylinositol 4,5-diphosphate (PIP2) produces IP3, which releases Ca2+ from the endoplasmic reticulum (ER), and DAG, which activates protein kinase C (PKC). CaBP, Ca2+-binding proteins, and physiologic response
https://wn.com/Inositol_Trisphosphate_(Ip3)_Diacylglycerol_(Dag)_As_Second_Messengers
release of inositol triphosphate (IP3) and diacylglycerol (DAG) as second messengers. Binding of ligand to G protein-coupled receptor activates phospholipase C (PLC)β. Alternatively, activation of receptors with intracellular tyrosine kinase domains can activate PLCγ. The resulting hydrolysis of phosphatidylinositol 4,5-diphosphate (PIP2) produces IP3, which releases Ca2+ from the endoplasmic reticulum (ER), and DAG, which activates protein kinase C (PKC). CaBP, Ca2+-binding proteins, and physiologic response
- published: 15 Mar 2019
- views: 892
5:42
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and...
published: 26 Jun 2018
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
- Report rights infringement
- published: 26 Jun 2018
- views: 174052
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets.
Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
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Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
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DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
3:27
IP3 DAG Calcium Pathway
IP3-mediated signal transduction pathways
First messengers are extracellular signaling mol...
published: 13 Oct 2019
IP3 DAG Calcium Pathway
IP3 DAG Calcium Pathway
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- published: 13 Oct 2019
- views: 182029
IP3-mediated signal transduction pathways
First messengers are extracellular signaling molecules, such as hormones or neurotransmitters. In response to exposure to these first messengers, intracellular signaling molecules called second messengers are released by the cell. Two such second messengers are IP3 and DAG.
Calcium is also an important second messenger. Transient increases in cytoplasmic Ca2+ levels are caused by the binding of some hormones and signal molecules, and this can send important intracellular signals, by activating calcium-binding proteins that then perform various functions. Note that cytosolic increases in calcium concentration can occur in two ways. There are reservoirs of calcium that can be opened within the cell by the second messenger IP3 – the endoplasmic reticulum and calciosomes. Otherwise, cyclic AMP can activate the opening of calcium channels in the plasma membrane so that extracellular calcium can rush in.
G-protein-coupled receptors, or GPCRs, are integral membrane proteins, meaning that they are locked into the cell membrane. They are locked in via 7 transmembrane α-helical segments. GPCRs recognize ligands through an extracellular recognition site. They also have an intracellular recognition site for a G protein. When a ligand binds the extracellular recognition site of a GPCR, this induces a conformational change, activating the G-Protein.
There are different kinds of G proteins, sometimes also called membrane-associated heterotrimeric G proteins. Gs activates adenylyl cyclase. Gi inhibits adenylyl cyclase.
Gq has three subunits – α, β, and γ. A conformational change in the GPCR activates the G protein. When this happens, the GDP on the Gα subunit gets replaced by GTP. This drives dissociation of the Gα subunit from the Gβγ complex. The now free Gα subunit can activate Phospholipase C-β.
Phosphatidylinositol-4-P (PIP) and phosphatidylinositol-4,5-biphosphate (PIP2) are produced through successive phorphorylations of phosphatidylinositol (PI). Once it is activated by a G-protein, Phospholipase C-β can break down PIP2.
PIP2 is hydrolyzed by phospholipase-C to produce inositol-1,4,5-triphosphate (IP3) and diacylglycerol (DAG), both of which act as second messengers. IP3 is hydrophilic, and diffuses into the cell, while DAG is lipophilic, and hence remains in the cell membrane. IP3 binds to calcium channel on endoplasmic reticulum (or the sarcoplasmic reticulum in the case of muscle cells) and allows release of calcium from the endoplasmic reticulum lumen. DAG, with the help of the calcium released from the endoplasmic reticulum, activates the calcium-dependent Protein Kinase C. Once activated, protein kinase C adds phosphates to target proteins and causes cellular responses.
13:15
Insights into inositol 1,4,5-trisphosphate receptor structure and function
Webcast of the presentation entitled 'Insights into inositol 1,4,5-trisphosphate receptor ...
published: 22 Oct 2014
Insights into inositol 1,4,5-trisphosphate receptor structure and function
Insights into inositol 1,4,5-trisphosphate receptor structure and function
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- published: 22 Oct 2014
- views: 637
Webcast of the presentation entitled 'Insights into inositol 1,4,5-trisphosphate receptor structure and function from playing LEGO with receptor subunits ' given by David Yule (University of Rochester, USA). Presented at the Biochemical Society focus meeting 'Calcium Signalling: The Next Generation' held at Charles Darwin House, United Kingdom at 9 - 10 September 2014.
0:46
Inositol triphosphate (IP3) | Calcium release
GPCRs step by step in following videos
GPCRs (G protein linked cell signaling)
https://you...
published: 08 Dec 2011
Inositol triphosphate (IP3) | Calcium release
Inositol triphosphate (IP3) | Calcium release
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- published: 08 Dec 2011
- views: 44507
GPCRs step by step in following videos
GPCRs (G protein linked cell signaling)
https://youtu.be/GSjVKVGK_1o
GPCRs (Activation of G protein receptor)
https://youtu.be/Le_f5cxpD4w
GPCRs (phospholipase C activation IP3 & DAG, Diacyl Glycerol)
https://youtu.be/2bbBrpgeheY
GPCRs - (Inositol triphosphate (IP3) Calcium release)
https://youtu.be/lsYBeFqEwzk
GPCRs- (Di acyl glycerol (DAG) activates protein Kinase C (PKC)
https://youtu.be/larIxw_9ePU
GPCRs- (Adenyl Cyclase and cAMP)
https://youtu.be/0nA2xhNiAow
GPCRs- (Protein kinase A activation by cAMP )
https://youtu.be/NaOBRvAFiJQ
#BiotechReview #GPCRs #GProtein #CellSignaling #SignalTransduction #IP3
6:56
What is the role of inositol triphosphate?
published: 12 Oct 2020
What is the role of inositol triphosphate?
What is the role of inositol triphosphate?
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- published: 12 Oct 2020
- views: 650
1:23
Inositol 1,4,5-Trisphosphate Receptor (IP3R) Model in a Dendritic Spine
This video visualizes the IP3 receptor model in a realistic spine reconstruction, simulate...
published: 09 Jun 2020
Inositol 1,4,5-Trisphosphate Receptor (IP3R) Model in a Dendritic Spine
Inositol 1,4,5-Trisphosphate Receptor (IP3R) Model in a Dendritic Spine
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- published: 09 Jun 2020
- views: 120
This video visualizes the IP3 receptor model in a realistic spine reconstruction, simulated using STEPS (http://steps.sourceforge.net/) simulator. It demonstrates the activation of IP3 receptors on the Endoplasmic Reticulum (ER) membrane by cytosolic Ca2+, leading to the release of Ca2+ from the ER and the rapid increase of cytosolic Ca2+ concentration, which in turn increases the number of open-state IP3 receptors.
Published in:
W. Chen and E. De Schutter: Python-based geometry preparation and simulation visualization toolkits for STEPS. Frontiers in Neuroinformatics 8: 37 (2014).
https://www.frontiersin.org/articles/10.3389/fninf.2014.00037/full.
19:44
Caged Inositol Trisphosphate Part 1
In this video we discuss what caged inositol trisphosphate is and c=give an example of an ...
published: 05 Jan 2015
Caged Inositol Trisphosphate Part 1
Caged Inositol Trisphosphate Part 1
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- published: 05 Jan 2015
- views: 121
In this video we discuss what caged inositol trisphosphate is and c=give an example of an experimental construct which makes use of it.
6:52
Inositol triphosphate and Diacylglycerol Pathway by Dr. Nitin Nema
It is one of the most widespread pathways of intracellular signaling which is derived from...
published: 04 Aug 2019
Inositol triphosphate and Diacylglycerol Pathway by Dr. Nitin Nema
Inositol triphosphate and Diacylglycerol Pathway by Dr. Nitin Nema
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- published: 04 Aug 2019
- views: 1097
It is one of the most widespread pathways of intracellular signaling which is derived from the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 forms different second messenger system which ultimately produces biological response through the mobilization of stored energy in the cell via Calcium release mechanism.#Inositoltriphosphate#GPCR#Diacylglycerol#
0:09
Inositol 1,4,5-trisphosphate
receptor (Anti-ITPR1)(Anti-Sj) in Purkinje cells of the cerebellum.
For more videos abut immunofluorescence patterns click 👇👇👇
Immunofluorescence: https://w...
published: 23 May 2022
Inositol 1,4,5-trisphosphate
receptor (Anti-ITPR1)(Anti-Sj) in Purkinje cells of the cerebellum.
Inositol 1,4,5-trisphosphate receptor (Anti-ITPR1)(Anti-Sj) in Purkinje cells of the cerebellum.
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- published: 23 May 2022
- views: 15
For more videos abut immunofluorescence patterns click 👇👇👇
Immunofluorescence: https://www.youtube.com/playlist?list=PLRDmErrHTaZ36bY-Sx7cu7Y59iMb2AtSc
10:35
INOSITOL TRISPHOSPHATE (IP3) & DIACYLGLYCEROL (DAG) AS SECOND MESSENGERS
release of inositol triphosphate (IP3) and diacylglycerol (DAG) as second messengers. Bind...
published: 15 Mar 2019
INOSITOL TRISPHOSPHATE (IP3) & DIACYLGLYCEROL (DAG) AS SECOND MESSENGERS
INOSITOL TRISPHOSPHATE (IP3) & DIACYLGLYCEROL (DAG) AS SECOND MESSENGERS
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- published: 15 Mar 2019
- views: 892
release of inositol triphosphate (IP3) and diacylglycerol (DAG) as second messengers. Binding of ligand to G protein-coupled receptor activates phospholipase C (PLC)β. Alternatively, activation of receptors with intracellular tyrosine kinase domains can activate PLCγ. The resulting hydrolysis of phosphatidylinositol 4,5-diphosphate (PIP2) produces IP3, which releases Ca2+ from the endoplasmic reticulum (ER), and DAG, which activates protein kinase C (PKC). CaBP, Ca2+-binding proteins, and physiologic response
Inositol trisphosphate receptor
Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory. Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca2+ from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca2+ signals characterized by complex patterns relative to both space and time. For example, Ca2+ waves and oscillations. The InsP3 receptor was first purified from rat cerebellum by neuroscientists Surachai Supattapone and Solomon Snyder at Johns Hopkins University School of Medicine.
Distribution
It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the InsP3Rs are found in the cell integrated into the endoplasmic reticulum.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Inositol_trisphosphate_receptor
Inositol Triphosphate (IP3) and Calcium Signaling ...
IP3 DAG Calcium Pathway...
Insights into inositol 1,4,5-trisphosphate recepto...
Inositol triphosphate (IP3) | Calcium release...
What is the role of inositol triphosphate?...
Inositol 1,4,5-Trisphosphate Receptor (IP3R) Model...
Caged Inositol Trisphosphate Part 1...
Inositol triphosphate and Diacylglycerol Pathway b...
Inositol 1,4,5-trisphosphate receptor (Anti-ITPR1...
INOSITOL TRISPHOSPHATE (IP3) & DIACYLGLYCEROL (DAG...
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by Rebecca St. James
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by St. James Rebecca
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by Terra Naomi
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by Colorblind
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by Billy Bauer
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by Trademark Da Skydiver
Way Up Here
by: Rebecca St. JamesBy Bob Farrell & Eddie DeGarmo
I walk along this winding road
Too many voices tell me which way to go
Sometimes this heart gets so confused
I need you Lord to show me
Which path to choose
And I'm longing for that place way up high
Where God's air is sweet and I touch the sky
Way up here I can see the far horizon
All the world before my eyes is clear to see
Way up here where my Father always meets me
On this mountain where he heals me I can rest
Way up here
Rising above this life we know
Leaving the streams of sorrow far down below
I feel the touch of God's loving hand
Restoring me in ways I can't understand
If I fall away his love reaches me
And he brings me back
To the edge of my dreams
Way up here I can see the far horizon
All the world before my eyes is clear to see
Way up here where my Father always meets me
On this mountain where he heals me I can rest
Way up here
No matter where we travel, no need to fear the shadows
My God is there
His light is there to follow
Back to the quiet waters
I know he cares
Way up here I can see the far horizon
All the world before my eyes is clear to see
Way up here where my Father always meets me
On this mountain where he heals me I can rest
Way up here
(chorus repeated)
Latest News for: ip3r
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AMPK–FOXO–IP3R signaling pathway mediates neurological and developmental defects caused by mitochondrial DNA mutations
Proceedings of the National Academy of Sciences, Volume 120, Issue 36, September 2023 ... .
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