Frank Hyneman Knight (November 7, 1885 - April 15, 1972) was an American economist who spent most of his career at the University of Chicago, where he became one of the founders of the Chicago school. Nobel laureates James M. Buchanan, Milton Friedman, George Stigler, and Ronald Coase were all students of Knight at Chicago. Knight supervised Stigler's Ph.D. thesis.

Frank H. Knight (B.S. and A.M., Tennessee, 1913; Ph.D., Cornell, 1916) was born in McLean County, Illinois, in 1885. Most of his academic career has been spent at the University of Chicago, where he is the Morton D. Hall Distinguished Service Professor, Emeritus, of Social Science and Philosophy. Knight is one of the world's leading economists, having made significant contributions to many problems of both economic theory and social philosophy. He is best known for his Risk Uncertainty and Profit, a monumental study of the role of the entrepreneur in economic life. In 1950 he was president of the American Economic Association and in 1957 the recipient of its coveted Francis A. Walker Award, given "not more frequently than once every five years to the living (American) economist who in the judgment of the awarding body has during his career made the greatest contribution to economics."