Urokinase receptor

The Urokinase receptor, also known as uPA receptor or uPAR or CD87 (Cluster of Differentiation 87), is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. uPAR was originally identified as a saturable binding site for urokinase on the cell surface.

Molecular characteristics

uPAR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. All three domains are necessary for high affinity binding of the primary ligand, urokinase. It has been possible to express uPAR recombinantly in CHO-cells and S2 cells from Drosophila melanogaster. 4 out of 5 of the possible glycosylation sites are used in vivo giving the protein a molecular weight of 50-60 kDA. Recently the structure of uPAR was solved by X-ray crystallography in complex with a peptide antagonist and with its native ligand, urokinase.

Besides the primary ligand urokinase, uPAR interacts with several other proteins, among others: vitronectin, the uPAR associated protein (uPARAP) and the integrin family of membrane proteins.

Pokémon GO

Pokémon GO is an upcoming augmented reality game for mobile phones developed by Niantic, scheduled to be released in 2016 for iOS and Android devices. The game will be released alongside the Pokémon Go Plus, a small wearable device developed by Nintendo, which uses a Bluetooth connection to notify users when a Pokémon is nearby with a LED and a light rumble. The game will allow players to capture, battle, train and trade virtual Pokémon who appear throughout the real world. The game will be free-to-play, although it will support in-app purchases.

The idea for the game was conceived in 2013 by Satoru Iwata of Nintendo and Tsunekazu Ishihara of The Pokémon Company. In 2015, Ishihara dedicated his speech at the game's announcement on September 10 to Iwata, who died two months earlier. Ishihara and his wife had played Ingress. Different Pokémon will live in different areas of the world - for example, water type Pokémon will live near water. There will be events held where players can trade Pokémon to build up their collection. A wristband device called the "Pokémon Go Plus" will ship with the game, to allow a more "heads-up" gaming experience than Ingress, where the player can be alerted to a nearby Pokémon by the Go Plus vibrating, press the button in a coded sequence to capture it and check the app later to find out what they've captured. The decision to create the Go Plus rather than create a smart watch app was to increase uptake among players for whom a smart watch is prohibitively expensive.

Yo Yo Honey Singh

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Hirdesh Singh (born 15 March 1983), better known by his stage name Yo Yo Honey Singh or Honey Singh is an Indian people rapper, music producer, singer and film actor. He started as a session and recording artist, and became a Bhangra music producer. He has also begun to produce music for Bollywood films, and gone on to become one of the highest-paid music producers in Bollywood.

Early life

Singh was born on 15 March 1983 at Hoshiarpur, Punjab to a Sikh family. His birth name is Hirdesh Singh. He studied music at the Trinity School in the United Kingdom. Later on, his family moved to Delhi.

Personal life

Singh is married to Shalini Talwar Singh, whom he introduced to audience for first time on India's Raw Star TV show.

Promotion

Singh and Diljit Dosanjh's song Lak 28 Kudi Da reached No 1 in BBC Asian Download Charts in May 2011. The song was released a promotional track for Diljit Dosanjh's film Lion of Punjab.

Pokémon

Pokémon (ポケモン, Pokemon, /ˈpoʊkeɪˌmɒn/ POH-kay-mon) is a media franchise owned by The Pokémon Company, and created by Satoshi Tajiri in 1995. It is centered on fictional creatures called "Pokémon", which humans known as Pokémon Trainers catch and train to battle each other for sport.

The franchise began as a pair of video games for the original Game Boy, developed by Game Freak and published by Nintendo. The franchise now spans video games, trading card games, animated television shows and movies, comic books, and toys. Pokémon is the second-most successful and lucrative video game-based media franchise in the world, behind only Nintendo's Mario franchise.

The franchise celebrated its tenth anniversary in 2006. Cumulative sales of the video games (including home console games, such as Hey You, Pikachu! for the Nintendo 64) have reached more than 200 million copies. In November 2005, 4Kids Entertainment, which had managed the non-game related licensing of Pokémon, announced that it had agreed not to renew the Pokémon representation agreement. Pokémon USA Inc. (now The Pokémon Company International), a subsidiary of Japan's Pokémon Co., now oversees all Pokémon licensing outside of Asia. As of 2013, the Pokémon media franchise has grossed revenues of ¥4 trillion worldwide (equivalent to US$37.76 billion). The brand earned $2 billion in 2014 alone.

Yo Yo

Yo Yo is a 1965 film by Pierre Étaix. It was entered into the 1965 Cannes Film Festival.

Plot

Yo Yo is the son of a 1920s billionaire who, although having everything he fancies and living in a cavernous old castle, is not happy, fancying the simple life of a beautiful circus actress. When the stock-exchange crashes, rendering him both poor and free. Thus, he joins the circus where his love interest is performing, and fall madly in love. They have a son who starts in the circus as a clown, but later becomes a successful actor star and uses his new wealth to buy back his father's castle.

References

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