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Enzyme inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. They are also used in pesticides. Not all molecules that bind to enzymes are inhibitors; enzyme activators bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
The binding of an inhibitor can stop a substrate from entering the enzyme's active site and/or hinder the enzyme from catalyzing its reaction. Inhibitor binding is either reversible or irreversible. Irreversible inhibitors usually react with the enzyme and change it chemically (e.g. via covalent bond formation). These inhibitors modify key amino acid residues needed for enzymatic activity. In contrast, reversible inhibitors bind non-covalently and different types of inhibition are produced depending on whether these inhibitors bind to the enzyme, the enzyme-substrate complex, or both.
Aube
Aube (French pronunciation: [ob]) is a French department in the Alsace-Champagne-Ardenne-Lorraine region of north-eastern France. As with sixty departments in France, this department is named after a river: the Aube. With 305,606 inhabitants (2012), Aube is 76th department in terms of population. The inhabitants of the department are known as Aubois or Auboises
The department was constituted as it is today by a decree of the National Assembly of 15 January 1790.
Geography
Location
The Aube department is located in the south-west side of the Alsace-Champagne-Ardenne-Lorraine region. It borders the departments of Marne in the north (about 130 km long), Haute-Marne to the east (about 100 km long), Côte-d'Or in the south-east (about 45 km long), Yonne in the south-west (about 175 km long), and Seine-et-Marne in the west (about 45 km long).
Subregions of Aube
Within the department regions of natural or traditional countryside can be identified as follows:
Radio Stations - Département de l'Aube
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Aube
ALBUMS
- Variable Ambit released: 2011
- Metal on Metal released: 2008
- Ambera Planeta Wawar released: 2007
- Imagery Resonance released: 2007
- Reworks Nimh, Volume 1 released: 2007
- Comet released: 2006
- Reworks Maurizio Bianchi, Volume 2 released: 2006
- Mectpyo Saisei released: 2005
- Junkyo released: 2005
- Chain [Re] Action released: 2005
- Reworks Maurizio Bianchi, Volume 1 released: 2005
- Reworks Stefano Gentile released: 2005
- Duplex-Sphere released: 2004
- Tapes 1992-1997 released: 2003
- Vinyls 1996 + 1998 released: 2003
- Vinyls 1995 + 1997 released: 2003
- Data-X released: 2002
- Redintegration released: 2002
- Spatio Temporal Cluster released: 2002
- Millennium released: 2002
- Millennium: December released: 2002
- Millennium: November released: 2002
- Millennium: October released: 2002
- RM4 released: 2002
- Howling Obsession (Revised) released: 2002
- Timemind released: 2001
- Millennium: Iulius released: 2001
- Millennium: Augustus released: 2001
- Millennium: September released: 2001
- Sensorial Inducement released: 2000
- 365-2001 released: 2000
- Millennium: Iunius released: 2000
- Millennium: Maius released: 2000
- Millennium: Aprilis released: 2000
- Millennium: Februarius released: 2000
- Millennium: Ianuarius released: 2000
- Millennium: Martius released: 2000
- Triad Thread released: 2000
- Set On released: 2000
- Solid Pressure released: 2000
- Suppression Disorder released: 1999
- Shade-Away released: 1999
- Ricochetentrance released: 1999
- 108 released: 1999
- Mutation released: 1999
- Blood-Brain Barrier released: 1999
- Deglaze released: 1998
- Cerebral Disturbance released: 1998
- 3 Cadavres Exquis released: 1998
- Splinter Clear Cut / Joyous Smash released: 1998
- Flare released: 1998
- Substructural Penetration 1991-1995 released: 1998
- Flush released: 1998
- Embers released: 1998
- Pages From the Book released: 1998
- Evocation released: 1998
- Vas in Euthymic Violet released: 1997
- Throb in Manic Red released: 1997
- Sigh in Depressive Blue released: 1997
- Aube / Knurl Split released: 1997
- Stared Gleam released: 1997
- New Forms of Free Entertainment released: 1997
- Dazzle Reflexion released: 1997
- Aqua Syndrome released: 1997
- Cardiac Strain released: 1997
- Grind Carve released: 1996
- Feed the Fishes released: 1996
- Quadrotation released: 1996
- Infinitely Orbit released: 1996
- Maschinenwerk released: 1996
- The Mind of a Missile released: 1996
- Métal de Métal released: 1996
- Pulse Resonator released: 1995
- Metalustration released: 1995
- Entangle Spirant released: 1995
- Magnetostriction released: 1995
- Purification to Numbness released: 1995
- Wired Trap released: 1995
- Frequency for Collapse released: 1994
- Emotional Oscillation released: 1994
- Recycled released: 1994
- E-Power released: 1994
- Flood-Gate released: 1993
- Luminous released: 1993
- Flash-Point released: 1993
- Spindrift released: 1992
Aube
ALBUMS
- ケミカルサーカス released: 2012
