S660A

In its United Kingdom Tax Bulletin 64 (April 2003), the Inland Revenue (now HM Revenue and Customs) announced new guidance on the "settlements legislation". This is a body of law which seeks to prevent someone (known as the "settlor") from avoiding tax by reclassifying income as belonging to someone else (known as the beneficiary). The income is then taxed at the beneficiary’s lower rate although the settlor continues to benefit from it. The legislation targets spouses and also parents seeking to divert income via their minor children.

The section of the legislation is 660A of the UK Income and Corporation Taxes Act 1988. Using the revised (April 2003) interpretation of s.660A, UK HMRC have been targeting businesses set up by spouses where they are aware that income is split between the spouses, and only one of them directly generates that income. In theory s.660A can apply to partnerships as well as limited companies, this has yet to be tested in the UK courts. In 2007 the interpretation was finally rejected by the Law Lords, resulting in the government proposing new leglisation to tackle the perceived abuse.

S100A13

S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene.

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions

S100A13 has been shown to interact with SYT1 and FGF1.

Pathology

Up-regulation of S100A13 was detected in cystic papillary thyroid carcinoma and association of S100A13 expression and chemotherapy resistance was shown in proteomics study of melanoma.

S100A11

S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the S100A11 gene.

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.

Interactions

S100A11 has been shown to interact with Nucleolin and S100B.

References

Further reading

Holiday (comics)

Holiday or the Holiday Killer is a fictional character appearing in the Batman story The Long Halloween (1996-1997) by writer Jeph Loeb and artist Tim Sale. The character is a serial killer who kills members of Gotham City's mobsters and corrupt officials on major holidays. The true identity of the killer is never definitively revealed in the story itself; both Alberto Falcone and Gilda Dent confess to being Holiday, with Gilda claiming she committed the first three murders and that her husband Harvey took over subsequently.

Fictional character biography

Set shortly after the events of Frank Miller's Batman: Year One, The Long Halloween follows the crusade of Batman, Captain James Gordon and Harvey Dent to topple mobster Carmine Falcone's crime family. At the same time, however, a mysterious assailant begins killing mafiosi on holidays, starting with Halloween.

The killer's identity remains a mystery for most of the story, but the method is always the same. The killer's weapon is a .22 pistol (using a rubber baby bottle nipple as a silencer) with the handle taped and the serial number filed off, which is left at the crime scene along with a holiday trinket representative of the holiday. This leads to the nickname "The Holiday Killer".

Holiday '80

Holiday '80 is an EP released by the original line-up of the British synthpop band The Human League. The EP was issued in the UK by Virgin Records in April 1980, a month before the release of the band's second album Travelogue. The EP peaked at no. 56 in the UK Singles Chart in May 1980, but was later reissued and returned to the chart, peaking at no. 46 in February 1982.

The recordings were produced with John Leckie, who had also been working with new wave bands such as Simple Minds and XTC. The principal song on the EP was "Marianne", however Virgin felt the band's preferred version of the track was not strong enough and refused to release it. "Dancevision" was an instrumental. The EP also featured a new, more elaborate recording of the band's debut single "Being Boiled", which would subsequently be included on the Travelogue album. The last track was a medley consisting of a cover of Gary Glitter's "Rock and Roll" (titled "Rock 'n' Roll" in the track listings) seguéing into the Iggy Pop track "Nightclubbing". The Japanese release also features the song "Toyota City", which also appears on Travelogue.

Holiday (Naughty by Nature song)

"Holiday" is the fourth and final single released from Naughty by Nature's fifth album, Nineteen Naughty Nine: Nature's Fury. It was released on October 20, 1999 and was the final release that Naughty by Nature released during their short-lived tenure at Arista Records. The song narrowly missed the Hot R&B/Hip-Hop Singles & Tracks, instead making it to #1 on the Bubbling Under R&B/Hip-Hop Singles. The song went Top 10 in Australia, becoming the group's biggest selling single there.

The song is built entirely around a dramatically slowed down sample of Change's 1980 #1 US Dance hit single A Lovers Holiday.

Single track listing

A-side

B-side

References

War (painting)

War is a painting created by Portuguese-British visual artist Paula Rego in 2003.

Description

War is a large pastel on paper composition measuring 1600mm x 1200mm. A rabbit-headed woman stands prominently in the center carrying a wounded child, surrounded by several realistic and fantastic figures recalling a style Rego describes as "beautiful grotesque".

For The Telegraph's Alastair Sooke, "The more you look at War, the curiouser and curiouser it becomes. Rego's white rabbits owe more to Richard Kelly's film Donnie Darko than Lewis Carroll's Wonderland."

Background

The painting first appeared as part of Rego's "Jane Eyre and Other Stories" exhibition at Marlborough Fine Art in London in 2003. It was inspired by a photograph that appeared in The Guardian near the beginning of the Iraq War, in which a girl in a white dress is seen running from an explosion, with a woman and her baby unmoving behind her. In an interview conducted in relation to the Museo Nacional Centro de Arte Reina Sofía's 2007 exhibition, Rego said of this painting, "I thought I would do a picture about these children getting hurt, but I turned them into rabbits' heads, like masks. It’s very difficult to do it with humans, it doesn’t get the same kind of feel at all. It seemed more real to transform them into creatures."