- published: 05 Sep 2014
- views: 84429
Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. Other signs and symptoms include sinus infections, poor growth, fatty stool, clubbing of the fingers and toes, and infertility in males among others. Different people may have different degrees of symptoms.
CF is inherited in an autosomal recessive manner. It is caused by the presence of mutations in both copies of the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Those with a single working copy are carriers and otherwise mostly normal. CFTR is involved in production of sweat, digestive fluids, and mucus. When CFTR is not functional, secretions which are usually thin instead become thick. The condition is diagnosed by a sweat test and genetic testing. Screening of infants at birth takes place in some areas of the world.
Inherited disorder manifests with no cure
Defective genes carry this abnormality
Cell clusters fail to create necessary juices
Deficient pancreatic enzymes prohibit the digestive process
Weakling newborn not capable of fending for itself
Clogged passages instill upper lung infection
Obstruction of intestinal glands
Foul smelling stool blocks the bowel
Gradual liver atrophy impairs insulin production
Infant ravaged with diabetes
Medicine administered to stabilize blood sugar
Thick mucus blocks the exocrine glands
Respiratory contamination spreads within
Debilitating illness cuts chance of survival