Fear Itself was a horror/suspense anthology television series shot in the city of Edmonton, Alberta, Canada, with some additional shooting in the city of St. Albert and the town of Devon, Alberta. It began airing on June 5, 2008 on NBC.

The show aired Thursday nights at 10/9c. It was put on hiatus for the duration of the 2008 Summer Olympics, with the promise of a return once the event was over, but no further episodes were aired.^{[citation needed]} While NBC failed to comment on the fate of the series once the Olympics ended, its time-slot was thereafter filled with re-runs of other NBC shows and Fear Itself did not appear on the NBC Fall 2008 schedule.^{[citation needed]}

Its title is derived from the famous Franklin D. Roosevelt quote "The only thing we have to fear is fear itself." The anthology was borne out of Masters of Horror and shares several of the same creative elements: self-contained horror/thriller stories directed by the biggest horror directors working in features today; both shows were created by Mick Garris and both shows are produced by Industry Entertainment's Andrew Deane, Adam Goldworm and Ben Browning. Stuart Gordon, Brad Anderson, John Landis and Rob Schmidt all directed at least one episode of each series. Guest stars included Eric Roberts, Anna Kendrick, Brandon Routh, Briana Evigan, Elisabeth Moss, and Cory Monteith. The song in the opening credits is entitled "Lie Lie Lie" by System of a Down front man Serj Tankian, from his first solo album Elect the Dead.