Lyn

Lyn or LYN may refer to:

A surname, variant of Lynn

In television and film:

In biochemistry:

Inanimate entities:

In other fields:

LYN

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.

Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. In various hematopoietic cells, Lyn has emerged as a key enzyme involved in the regulation of cell activation. In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor (BCR),CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the Src kinase family.

Function

Lyn has been described to have an inhibitory role in myeloid lineage proliferation. Following engagement of the B cell receptors, Lyn undergoes rapid phosphorylation and activation. LYN activation triggers a cascade of signaling events mediated by Lyn phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the receptor proteins, and subsequent recruitment and activation of other kinases including Syk, phosholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. These kinases provide activation signals, which play critical roles in proliferation, Ca²⁺ mobilization and cell differentiation. Lyn plays an essential role in the transmission of inhibitory signals through phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based inhibitory motifs (ITIM) in regulatory proteins such as CD22, PIR-B and FCγRIIb1. Their ITIM phosphorylation subsequently leads to recruitment and activation of phosphatases such as SHIP-1 and SHP-1, which further downmodulate signaling pathways, attenuate cell activation and can mediate tolerance. In B cells, Lyn sets the threshold of cell signaling and maintains the balance between activation and inhibition. Lyn thus functions as a rheostat that modulates signaling rather than as a binary on-off switch.

Lyn (singer)

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Lee Se-jin (born on Seoul, South Korea on 9 November 1981) is a South Korean R&B singer known professionally as Lyn. She has released ten full albums to date.

Biography

Lyn was born in Seoul, South Korea on 9 November 1981. She graduated from Seoul High School and attended University of Seoul.

Career

Lyn was first scouted by an agency because of her voice and from there, she first made her debut under her real name, Lee Se-jin, and released an album. The album sold poorly and was barely known. Lyn then took some time off to train vocally. She made a comeback in 2002 under the name Lyn with her supposedly first album Have You Ever Have A Broken Heart?. It was very successful and was able to shoot her up to one of the top R&B female solo singer of the year. After a surprise two years hiatus, Lyn released her second album Can U See The Bright. The album was very successful, surpassing her previous album with her popular single, "사랑했잖아" (Used To Love). Due to its popularity, the song was eventually covered on another successful singer Lee Seung-gi's album, released in late 2006. Lyn released her third album, The Pride of the Morning, on March 7, 2007, and sold 15,358 copies in that month, placing second in the Music Industry Association of Korea's monthly chart. Again, it was a success and was once again reclaim her title as one of the best R&B female singer. Overall her album sold 25,171 copies. Lyn then released more albums afterwards, and did not become very successful, but in 2009 she made a comeback with her 5th album called 'Let Go, Let In, It's a New Day'. In early 2012, she released her 7th album title 'Love Fiction'.

Beatty

Beatty is a surname of Scottish and Irish origin. In the Scottish case, some have thought that it is derived from the name Bartholomew, which was often shortened to Bate or Baty. Male descendants were then often called Beatty, or similar derivations like Beattie or Beatey. The name Beatty or Beattie, others think, arose in Ireland from Betagh, a surname meaning hospitaller. A majority of people named Beatty or Beattie in Ireland are the descendants of Scots who came over to Ulster in the seventeenth century. Beattie is common in counties Antrim and Down, whilst Beatty is more common in counties Armagh and Tyrone. In Fermanagh in 1962, Beatty was the fifteenth most common name and was recorded as synonymous with the names Betty and MacCaffrey (or McCaffrey).

It is most likely that the name derives from Mac a'Bhiadhtaigh, from biadhtach, "one who held land on condition of supplying food (biad) to those billeted on him by the chief". In the rest of Ireland, the name Biadhtach (Betagh; "public victualler") was changed to Beatty or Beattie. In Scotland, the Beatties were a reiver clan in the Langholm area of Eskdale. George MacDonald Fraser has written about the reiving clans in "The Steel Bonnets : The Story of the Anglo-Scottish Border Reivers".

Beatty, Nevada

Beatty (pronounced BAY-dee) is an unincorporated community and a census-designated place (CDP) along the Amargosa River in Nye County in the U.S. state of Nevada. U.S. Route 95 runs through the CDP, which lies between Tonopah, about 90 miles (140 km) to the north, and Las Vegas, about 120 miles (190 km) to the southeast. State Route 374 connects Beatty to Death Valley National Park, about 8 miles (13 km) to the west.

Before the arrival of non-indigenous people in the 19th century, the region was home to groups of Western Shoshone. Established in 1905, the community was named after Montillus (Montillion) Murray "Old Man" Beatty, who settled on a ranch in the Oasis Valley in 1896 and became Beatty's first postmaster. With the arrival of the Las Vegas and Tonopah Railroad in 1905, the CDP became a railway center for the Bullfrog Mining District, including mining towns such as nearby Rhyolite. Starting in the 1940s, Nellis Air Force Base and other federal installations contributed to the town's economy as did tourism related to Death Valley National Park and the rise of Las Vegas as an entertainment center.

Fahrenheit 451

Fahrenheit 451 is a dystopian novel by Ray Bradbury published in 1953. It is regarded as one of his best works. The novel presents a future American society where books are outlawed and "firemen" burn any that are found. The title refers to the temperature that Bradbury asserted to be the autoignition temperature of paper. (In reality, scientists place the autoignition temperature of paper anywhere from high 440 degrees Fahrenheit to some 30 degrees hotter, depending on the study and type of paper.)

The novel has been the subject of interpretations focusing on the historical role of book burning in suppressing dissenting ideas. In a 1956 radio interview, Bradbury stated that he wrote Fahrenheit 451 because of his concerns at the time (during the McCarthy era) about the threat of book burning in the United States. In later years, he stated his motivation for writing the book in more general terms.

In 1954, Fahrenheit 451 won the American Academy of Arts and Letters Award in Literature and the Commonwealth Club of California Gold Medal. It has since won the Prometheus "Hall of Fame" Award in 1984 and a 1954 "Retro" Hugo Award, one of only four Best Novel Retro Hugos ever given, in 2004. Bradbury was honored with a Spoken Word Grammy nomination for his 1976 audiobook version.