C1orf173
Glutamate-rich protein 3, also known as Uncharacterized Protein C1orf173 or Chromosome 1 Open Reading Frame 173, is a protein encoded by the ERICH3 gene.
Gene
The ERICH3 gene in humans is 105,628 bases and is encoded on the minus strand at position 31.1 on the short arm of chromosome 1 from base pair 75,033,795 bp to 75,139,422 bp from pter. C1orf173's function in humans is still unclear though there is a link between expression of this gene and several forms of cancer, such as breast cancer and skin sarcomas. C1orf173 is expressed in the brain, eye, lung, mammary gland, muscle, pituitary gland, testis, trachea, and uterus.
Protein
The C1orf173 protein in humans is 1,530 amino acids in length and contains two domains of unknown function, DUF4590 and DUF4543. Both DUF regions are currently uncharacterized though they are found in eukaryotes including humans. There are currently three known isoforms of the C1orf173 protein in humans, Q5RHP9-1 (canonical), Q5RHP9-2 and Q5RHP9-3. Other animals tend to have a multitude of variant forms of this gene