- published: 13 Jul 2015
- views: 2475
Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the PPIA gene on chromosome 7. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Due to its various functions, PPIA has been implicated in a broad range of inflammatory diseases, including atherosclerosis and arthritis, and viral infections.
PPIA is an 18 kDa, 165-amino acid long cytosolic protein. Like other cyclophilins, PPIA forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti-parallel β-strands and capped by two α-helices at the top and bottom. In addition, the β-turns and loops in the strands contribute to the flexibility of the barrel. Its active site is a hydrophobic pocket that binds peptides containing proline. Cyclosporine can bind this pocket to inhibit the protein’s enzymatic activity.
Listen to five of our outstanding alumni talk about the impact that the PPIA Fellowship has had on their lives.
Fr. Manoling V. Francisco, S.J. has a lot of Tagalog mass songs that have melodies that puts one in a reflective and prayerful mood. This offertory song is one of those songs.https://youtu.be/MfhUX02SLcE Bukas Palad is a Catholic Filipino music ministry, bound by faith in God, passion for music, and dedication to serving others. Inspired by the spirituality of St. Ignatius of Loyola, the group strives to become co-creators with God in building a world of justice, peace, hope, and love by writing, performing, and propagating original liturgical and inspirational music. Piano Covers: https://www.youtube.com/playlist?list=PLo104AjfdhWn9369iyddo3-HXZG8adKGE Reflections https://youtu.be/UkABaniwIgY?list=PLo104AjfdhWk-057rRv-mHTX1QVdNG8h6 Lullabies https://youtu.be/Co2RvUfoDWUlist=PLo104...
This song is an all time favorite Tagalog communion mass song. The beautiful melody sings of one`s joy in expressing trust in God`s love and protection. https://youtu.be/xq7V-KfJi2Y Piano Covers: https://www.youtube.com/playlist?list=PLo104AjfdhWn9369iyddo3-HXZG8adKGE Reflections https://youtu.be/UkABaniwIgY?list=PLo104AjfdhWk-057rRv-mHTX1QVdNG8h6 Lullabies https://youtu.be/Co2RvUfoDWUlist=PLo104AjfdhWmiiEC1wfREgHGLbPsrSx6z Lyrics for Awit ng Paghahangad by Bukas Palad O Diyos Ikaw ang laging hanap, Loob ko'y Ikaw ang tanging hangad. Nauuhaw akong parang tigang na lupa Sa tubig ng ‘Yong pag-aaruga. Ika'y pagmamasdan sa dakong banal, Nang makita ko ang ‘Yong pagkarangal. Dadalangin akong nakataas aking kamay, Magagalak na aawit ng papuring iaalay. Gunita ko'y Ikaw Habang nahihi...
PPIA X USYD COMMITTEE OUTING 2017 Don't hesitate to contact us if you got any questions: +61 438 137 296 (Kenley Tjhin) Video by: Finten Damian Edited by: Finten Damian Disclaimer: We do not own the music in this video Music : Zedd - Find You ft. Matthew Koma, Miriam Bryant (https://www.youtube.com/watch?v=IgGjUjQRAxw)
Welcome to Australia! Here is a survival guide in New South Wales (Australia) that you need to know.
This video is about TRAVELING TO PRINCETON!!! Music from the legend Lil Sokz: https://www.youtube.com/user/SokzMusic
This past summer Leticia Matta and Ayana Russell (both MSPPM '12) participated in the Public Policy and International Affairs (PPIA) Junior Summer Institute, a six-week program that allows undergraduates to take graduate level courses. They share their experiences in this video.
This is actually a Tagalog version of Prayer for Generosity which is usually used as an offertory song. The melodic piano intro made it distinct and gives the listener a nostalgic feeling. https://youtu.be/XIAYcA_W2ns Access the Piano Tutorial here! http://ppia.globalgroup.co/panalanginsapagigingbukaspalad/ Piano Covers: https://www.youtube.com/playlist?list=PLo104AjfdhWn9369iyddo3-HXZG8adKGE Reflections https://youtu.be/UkABaniwIgY?list=PLo104AjfdhWk-057rRv-mHTX1QVdNG8h6 Lullabies https://youtu.be/Co2RvUfoDWU?list=PLo104AjfdhWmiiEC1wfREgHGLbPsrSx6z Lyrics [Intro] BbM7 – Am7 – Gm7 – FM7 – BbM7 – Am7 – Gm7- C7sus – C7 F C/E BbM7 C/Bb Am7 Dm7 Panginoon, turuan Mo akong maging bukas-palad. BbM7 C/Bb Am7 Dm7 Turuan Mo akong maglingkod sa Iyo, BbM7 Am7 A7 Dm7 Na magbigay ng a...
PPIA Unimelb's sobat mentoring program is finally back and ready to welcome first year undergraduate students to the university of melbourne! Sign up during o-week for an opportunity to build your connections by meeting new people and getting your own approachable and reliable tour guide, mentor and best friend! Limited spots only! Music: www.bensound.com
Song by: Martin Garrix & Brooks. Link: https://youtu.be/zH9sXggRlxc
We're asking our alumni to make short videos about what they got out of their JSI experience and what they are doing now.
Tomorrow's coming 'round
A hair-pin curve in the road
She's got a run in her stocking
And she's missing the heel of her shoe
Got up this morning rolled out of bed
I spilled a diet coke
Called my mother said, "Hi"
What I meant to say was, "Why is your life a joke?"
Then, I went down to that ugly bar and
I clicked my heels three times just like you said
And I climbed that road to your empty house
The anticipation was a turn on
But you let me down
'Coz, I stood on that empty street alone
I said, "I'm ready for my close up now, Mr. Demille"
I waited for the light, but it never shone
Well I wonder what you do with that expensive piece of land
That overlooks a billion years of history
I have a sneaking suspicion, you will never understand
Hey maybe I'll see you down by the Rocky and Bullwinkle
And we can talk to that charlatan psychic
And she can paint a prettier picture of your future
'Coz that day in my life, that day in my life
I dreamt tomorrow, had a prettier face
I dreamt tomorrow, would have better things to say
Than, "You look like shit, what's your problem, bitch?
You're legs feel like sandpaper, you can't do anything right"
'Coz that day, never should have taken place
'Coz this day, in my life still cannot explain
Why I listened in the first place to you?
Oh yeah, something else
I hope one day you call up your father
And you have the guts to tell him, how he hurt you
And he made you hurt another