AKT1

RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) domains. It is commonly referred to as PKB, or by both names as "Akt/PKB".

Function

The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mice lacking Akt1 display a 25% reduction in body mass, indicating that Akt1 is critical for transmitting growth-promoting signals, most likely via the IGF1 receptor. Mice lacking Akt1 are also resistant to cancer: They experience considerable delay in tumor growth initiated by the large T antigen or the Neu oncogene. A single-nucleotide polymorphism in this gene causes Proteus syndrome.

Diablo III

Diablo III is an action role-playing video game developed and published by Blizzard Entertainment. It is the third installment in the Diablo franchise and was released in the Americas, Europe, South Korea, and Taiwan on May 15, 2012, and Russia on June 7, 2012, for Microsoft Windows and OS X. A console version was released for the PlayStation 3 and Xbox 360 on September 3, 2013. Versions for PlayStation 4 and Xbox One were released on August 19, 2014.

In the game, players choose one of six character classes – Barbarian, Crusader, Demon Hunter, Monk, Witch Doctor or Wizard (with the Crusader being unavailable unless the player has purchased the expansion pack, Diablo III: Reaper of Souls) – and are tasked with defeating the Lord of Terror, Diablo.

Diablo III set a new record for fastest-selling PC game selling over 3.5 million copies in the first 24 hours of its release, and was the best selling PC game of 2012, selling over 12 million copies during the year. It has sold 30 million copies across all platforms. Diablo III received acclaim from critics, although its digital rights management that requires an internet connection at all times was criticized.