Madden NFL 2001 is an American football video game. It is the third in the Madden NFL series to include an NFL player, Tennessee Titans running back Eddie George, on its cover (the first being Madden NFL 95, which featured Erik Williams and Karl Wilson along with Madden himself). It is also the first game in the Madden NFL series to appear on the PlayStation 2 game console. This is the first Madden game to feature NFL Europe teams.

Madden NFL 2001 includes several customizable modes. Players have the ability to create a play, create a player, run a franchise, and collect Madden Cards, allowing players to perform certain actions during gameplay (for example, adding 5th downs, or limiting the CPU-controlled team to 3rd downs). The cards can also alter individual player ratings, unlock special stadiums, and unlock Hall of Fame and All-Madden teams.

The best teams in the game overall were the Jacksonville Jaguars and the St. Louis Rams with a score of 95. The worst team in the game overall was the San Diego Chargers with the score of 70. The best offense in the game belongs to the St. Louis Rams with the score of 95. A 3 way tie for the best defense in the game belongs to the Tampa Bay Buccaneers, the Baltimore Ravens and the Jacksonville Jaguars with scores of 95. The best special teams in the game belongs to the Denver Broncos with the score of 95.

Madden NFL (known as John Madden Football before 1993) is an American football video game series developed by Electronic Arts Tiburon for EA Sports. The game series is named after Pro Football Hall of Famer John Madden, a well-known former Super Bowl–winning coach of the Oakland Raiders and color commentator. The games have consistently been a best seller, and has even spawned TV shows where players compete. Among the game's realistic features include sophisticated playbooks and player statistics, and voice commentary that allows players to hear the game as if it were a real TV broadcast.

The series was originally conceived by Electronic Arts founder Trip Hawkins, who then approached Madden in 1984 for his endorsement and expertise. Due to Madden's insistence that the game be as realistic as possible, the first version of John Madden Football was not released until 1988. The second version of the game was released in 1990, with annual versions since then. The series' name was changed to Madden NFL in 1993 after EA acquired the rights to use NFL teams and players. Despite Madden's retirement as a broadcaster in 2009, he continues to lend his name and provide expertise for the game.