O-glycans direct selectin ligands to lipid rafts on leukocytes

Edit PNAS 25 Jun 2015
Here, we found that loss of core 1-derived O-glycans in murine C1galt1−/− neutrophils blocked raft targeting of PSGL-1, CD43, and CD44, but not of other glycosylated proteins, as measured by resistance to solubilization in nonionic detergent and by copatching with a raft-resident sphingolipid on intact cells ... C1galt1−/− neutrophils ......
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