- published: 30 Apr 2016
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Goes ( pronunciation (help·info)) is a municipality and a city in the southwestern Netherlands in Zuid-Beveland, in the province Zeeland. The city of Goes has approximately 27,000 residents.
Goes was founded in the 10th century on the edge of a river: de Korte Gos (the Short Gos). The village grew fast and in the early 12th century it had a market square and a church devoted to Maria. In 1405 Goes received city rights, and in 1417 it was allowed to build walls around the city. The prosperity of the city was based upon the cloth industry and the production of salt. In the 16th century Goes declined. Its connection to the sea got bogged down and in 1544 a large fire destroyed a part of the city.
In 1577 the Spanish soldiers who occupied Goes were driven out by Prince Maurits of Nassau. The prince built a defence wall around Goes, which is still partly present. In the centuries thereafter Goes did not play an important role, except as an agricultural centre. In 1868 a railway was constructed through it, but this did not lead to industrialisation. Agriculture remains the most important economic activity.
A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin is a very effective barrier; as a result, only medications whose molecules are small enough to penetrate the skin can be delivered by this method. A wide variety of pharmaceuticals are now available in transdermal patch form.
The first commercially available prescription patch was approved by the U.S. Food and Drug Administration in December 1979. These patches administered scopolamine for motion sickness.
I've tried and tried to run and hide
To find a life that's new
But wherever I go I always know
I can't escape from you
A jug of wine to numb my mind
But what good does it do?
The jug runs dry and still I cry
I can't escape from you
These wasted years are souvenirs
Of love I thought was true
Your memory is chained to me
I can't escape from you
There is no end, I can't pretend
That dreams will soon come true
A slave too long to a heart of stone
I can't escape from you