The Bank or Company of Saint George (Italian: Banco or Ufficio di San Giorgio, officially Casa delle Compere di San Giorgio) was a financial institution of the Republic of Genoa. Founded in 1407, it was one of the oldest chartered banks in Europe, if not the world. The bank's headquarters were at the Palazzo San Giorgio, which was built in the 13th century by order of Guglielmo Boccanegra, uncle of Simone Boccanegra, the first Doge of Genoa.

A number of prominent Genoese families were involved in the establishment and governance of the Bank, including the Houses of Grimaldi & Serra. Unusually for its time, the Bank made use of a number of Jewish agents, including the Ghisolfi clan that managed certain possessions around the Black Sea.

The Bank was governed by four consuls who administered its finances and directed investments. Because the Republic's ruling oligarchs were normally prominent in Bank politics, it is often difficult to determine where the Bank's influence ended and the Republic's began.

Saint George (c. 275/281 – 23 April 303) was, according to tradition, a Roman soldier from Syria Palaestina and a soldier in the Guard of Diocletian, who is venerated as a Christian martyr. In hagiography Saint George is one of the most venerated saints in the Catholic (Western and Eastern Rites), Anglican, Eastern Orthodox, and the Oriental Orthodox churches. He is immortalized in the tale of Saint George and the Dragon and is one of the Fourteen Holy Helpers. His memorial is celebrated on 23 April, and he is regarded as one of the most prominent military saints.

Many Patronages of Saint George exist around the world, including: Georgia, England, Egypt, Bulgaria, Aragon, Catalonia, Romania, Ethiopia, Greece, India, Iraq, Lithuania, Palestine, Portugal, Serbia, Ukraine and Russia, as well as the cities of Genoa, Amersfoort, Beirut, Botoşani, Drobeta Turnu-Severin, Timişoara, Fakiha, Bteghrine, Cáceres, Ferrara, Freiburg, Kragujevac, Kumanovo, Ljubljana, Pérouges, Pomorie, Preston, Qormi, Rio de Janeiro, Lod, Lviv, Barcelona, Moscow, Tamworth and the Maltese island of Gozo, as well as of the Scout Movement and a wide range of professions, organizations and disease sufferers.