Preacher is an American comic book series published by Vertigo, an imprint of DC Comics. The series was created by writer Garth Ennis and artist Steve Dillon with painted covers by Glenn Fabry.
The series consists of 75 issues in total - 66 regular, monthly issues, five one-shot specials and a four-issue Preacher: Saint of Killers limited series. The entire run has been collected in nine trade paperback editions. The final monthly issue, number 66, was published in October 2000.
Preacher tells the story of Jesse Custer, a preacher in the small Texas town of Annville. Custer is accidentally possessed by the supernatural creature named Genesis, the infant product of the unauthorized, unnatural coupling of an angel and a demon. The incident flattens Custer's church and kills his entire congregation.
Genesis has no sense of individual will, but since it is composed of both pure goodness and pure evil, its power might rival that of God Himself, making Jesse Custer, bonded to Genesis, potentially the most powerful being in the universe.