HEV

HEV may refer to:

Pro-hevein

Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced and a lectin-like protein from Hevea brasiliensis (rubber tree) where it is involved in the coagulation of latex.

The 187 amino-acid propeptide pro-hevein is cleaved in two fragments: a N-terminal 43 amino-acid Hevein bearing a chitin-binding type-1 domain (also known as CBM18 carbohydrate-binding module) that binds to chitin and a 138 amino-acid Win-like protein bearing a Barwin domain.

It has antifungal properties.

Role of hevein in latex allergy

Hevein is the main IgE-binding epitope of the major latex allergen prohevein as are hevein-like protein domains in fruit class I chitinases. Therefore it is a possible cause for allergen cross-reactivity between latex and banana or other fruits like chestnuts or avocadoes. Hevein-like genes can be found in many plants including Arabidopsis thaliana.

The conformational epitope on hevein is called Hev b 6.02.

References

External links

Enterovirus 68

Enterovirus 68 (EV68, EV-D68, HEV68) is a member of the Picornaviridae family, an enterovirus. First isolated in California in 1962 and once considered rare, it has been on a worldwide upswing in the 21st century. With some uncertainty, it has been implicated in cases of a polio-like disorder called acute flaccid myelitis.

Biology

EV68 is one of the more than one hundred types of enteroviruses, a group of ssRNA viruses containing the polioviruses, coxsackieviruses, and echoviruses. It is unenveloped. Unlike all other enteroviruses, EV68 displays acid lability and a lower optimum growth temperature, both characteristic features of the human rhinoviruses. It was previously called human rhinovirus 87 by some researchers.

Epidemiology

Since its discovery in 1962, EV68 had been described mostly sporadically in isolated cases. Six clusters (equal to or more than 10 cases) or outbreaks between 2005 and 2011 have been reported from the Philippines, Japan, the Netherlands, and the states of Georgia, Pennsylvania and Arizona in the United States. EV68 was found in 2 of 5 children during a 2012/13 cluster of polio-like disease in California.