- published: 27 Nov 2013
- views: 699916
Silver sulfadiazine (INN, or silvadene) is a topical sulfonamide/silverantibacterial used as a topical burn cream on burns, including chemical burns. It prevents the growth of a wide array of bacteria, as well as yeast, on the damaged skin.
Silver sulfadiazine is typically delivered in a 1% cream or aqueous suspension. Brand names include Silvadene (a genericized trademark), Silverex, Silvazine, Flamazine, Thermazene, and SSD.
Studies have found that silver sulfadiazine delays healing of wounds; and it is therefore not recommended by the authors of a Cochrane review.
An aseptic exudate (a clear fluid) may form on the wound's surface. Burning and painful sensations are not uncommon but only temporary.
About 0.1 to 1% of patients show hypersensitivity reactions like rashes or erythema multiforme. This is a reaction known from other sulfonamides including antibacterials, thiazide diuretics, and sulfonylurea antidiabetics; but data on the likelihood of cross-allergies are inconsistent.
Incorporation of the silver ions can lead to local argyria (discoloration of the skin), especially if the treated area is exposed to ultraviolet. Generalised argyria with silver accumulation in kidneys, liver and retina has only been found in association with excessive long-term use, or repeated use on severe and heavily inflamed burns. Possible consequences of generalised argyria include interstitial nephritis and anemia.
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