Brenda Milner, CC GOQ FRS FRSC (born 15 July 1918) is a Canadian neuroscientist who has contributed extensively to the research literature on various topics in the field of clinical neuropsychology.

Born in Manchester, England, Milner received her undergraduate degree at the University of Cambridge in 1939, and her Ph.D. degree under Donald Hebb at McGill University in 1952. She joined Wilder Penfield at the Montreal Neurological Institute in 1950 and published landmark papers with Penfield and William Beecher Scoville in 1957 and 1958. She was the Dorothy J. Killam Professor of Psychology, Montreal Neurological Institute and Department of Neurology & Neurosurgery at McGill University.

Milner was a pioneer in the field of neuropsychology and in the study of memory and other cognitive functions in humans. She was the first to study the effects of damage to the medial temporal lobe on memory and systematically described the deficits in the most famous patient in cognitive neuroscience, HM. Through a series of landmark studies, Dr. Milner showed that the medial temporal lobe amnestic syndrome is characterized by an inability to acquire new memories and an inability to recall established memories from a few years immediately before damage, while memories from the more remote past and other cognitive abilities, including language, perception and reasoning are intact. She also showed that in patients with this syndrome the ability to learn certain motor skills remained normal. This finding introduced the concept of multiple memory systems within the brain and stimulated an enormous body of research.