Girl, Interrupted is a 1999 drama film about a teenager's 18-month stay at a mental institution, starring Winona Ryder, Angelina Jolie, Brittany Murphy, Whoopi Goldberg and Vanessa Redgrave, with Jolie winning an Academy Award for her performance.

The film is an adaptation of author Susanna Kaysen's memoir. James Mangold directed, and he, Anna Hamilton Phelan, and Lisa Loomer wrote the screenplay.

Susanna Kaysen (Winona Ryder), 18 years old in April 1967, voluntarily checks herself into Claymoore Hospital after an overdose of aspirin and her stay extends for over a year. She denies the accusation from many that she was attempting to commit suicide, claiming that she was only "trying to make the shit stop". Nurses and therapists are surprised when Susanna acknowledges that she does not actually want to go to college and would like to become a writer.

She befriends fellow patients Polly "Torch" Clark (Elisabeth Moss), Georgina Tuskin (Clea DuVall), Daisy Randone (Brittany Murphy), Janet Webber (Angela Bettis), and Cynthia Crowley (Jillian Armenante) and forms a small troupe of troubled women in her ward. Susanna is particularly enchanted by Lisa Rowe (Angelina Jolie), a charismatic sociopath. When Lisa returns to the ward after running away she notices that her old best friend's place has been taken by Susanna. She demands to know what happened to her best friend, eventually realizing that she had committed suicide. Eventually, Lisa befriends Susanna and the two start causing trouble. Lisa encourages Susanna to stop taking her medications and/or trade them with others, and generally resist the influences of therapy.