The Cherokee syllabary is a syllabary invented by Sequoyah, also known as George Gist, to write the Cherokee language in the late 1810s and early 1820s. His creation of the syllabary is particularly noteworthy in that he could not previously read any script. He first experimented with logograms, but his system later developed into a syllabary. In his system, each symbol represents a syllable rather than a single phoneme; the 85 (originally 86) characters in the Cherokee syllabary provide a suitable method to write Cherokee. Some symbols do resemble the Latin, Greek and even the Cyrillic scripts' letters, but the sounds are completely different (for example, the sound /a/ is written with a letter that resembles Latin D).

Each of the characters represents one syllable, such as in the Japanese kana and the Bronze Age Greek Linear B writing systems. The first six characters represent isolated vowel syllables. Characters for combined consonant and vowel syllables then follow. It is recited from left to right, top to bottom.