- published: 21 Oct 2015
- views: 741
Aspartic acid (abbreviated as Asp or D; encoded by the codons [GAU and GAC]) is an ɑ-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated -+NH3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated –COO- form under biological conditions), and a side chain CH2COOH, classifying it as a charged(at physiological pH), aliphatic amino acid. It is semi-essential in humans, meaning the body can synthesize it from oxaloacetate.
Asp's L-isomer is one of the 23 proteinogenic amino acids, i.e., the building blocks of proteins. Asp (and glutamic acid) is classified as acidic, with a pKa of 3.9, however in a peptide this is highly dependent on the local environment (as with all amino acids), and could be as high as 14. Asp is pervasive in biosynthesis.
L-aspartic acid is one of the two main ingredients of the artificial sweetener aspartame, along with L-phenylalanine.
Aspartic acid was first discovered in 1827 by Auguste-Arthur Plisson and Étienne Ossian Henry, derived from asparagine, which had been isolated from asparagus juice in 1806, by boiling with a base.
Hi, this is Larry Hobbs @ FatNews.com. http://fatnews.com/ Aspartic Acid found in a mineral supplement made me feel incredibly anxious. I will tell you the story of what happened. I’ve taken handfuls of nutritional supplements every day since 1982. (33 years at this point.) This incident about aspartic acid making me feel anxious happen about 19 years ago (circa 1996). I was taking one (1) capsule of a magnesium / potassium supplement per day. Then I read an article about a study that was sponsored by the company that sold the product, saying that when they gave six (6) capsules per day of this supplement to athletes, it increased their endurance. I NO longer believe this study. (1did at the time (1996), but I no longer do.) Based on this study, I increased the dose of this magne...
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Arch Neurol. 2010;67(2):250-251. doi: 10.1001/archneurol.2009.317. Read the article here: http://ja.ma/1bBxH5c
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Aspartate titration - pI determination
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