Γδ T Cells

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TC BioPharm - Company Presentation

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Duration: 9:59
Updated: 22 Oct 2014

Presented by: Michael Leek, Ph.D., CEO Commercializing the anti-cancer cytotoxicity exhibited by γδ T cells, TC BioPharm is developing an autologous therapy which involves expansion of the cells over a two-three week period to formulate a treatment for a wide-variety of different tumor types. The manufacturing process comprises several steps. The first involves isolation of peripheral blood mononuclear cells; the second involves selection/activation of γδ T cells; the final stage requires culture expansion in a GMP environment, providing therapeutically relevant cell numbers prior to administration. Although there are many different approaches to T cell immunotherapy, the process has a compelling clinical safety and efficacy record, demonstrated by a cohort of published case histories. Moreover, when contrasted with novel immunotherapies such as PDL-1 and CTLA-4 inhibitors being developed by Roche and Bristol Myers Squibb respectively, use of γδ T cells may have a complimentary and synergistic therapeutic benefit. For more information on the 2014 Stem Cell Meeting on the Mesa visit www.stemcellmeetingonthemesa.com

http://wn.com/TC_BioPharm_-_Company_Presentation

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Combination therapies in cancer treatment – Video abstract [ID 61292]

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Duration: 3:11
Updated: 17 May 2015

Video abstract of a review paper “Enhancement of antibody-dependent cell mediated cytotoxicity: a new era in cancer treatment” published in the open access journal ImmunoTargets and Therapy by Rajasekaran N, Chester C, Yonezawa A, et al. Abstract: The therapeutic efficacy of some anti-tumor monoclonal antibodies (mAbs) depends on the capacity of the mAb to recognize the tumor-associated antigen and induce cytotoxicity via a network of immune effector cells. This process of antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells is triggered by the interaction of the fragment crystallizable (Fc) portion of the mAb with the Fc receptors on effector cells like natural killer cells, macrophages, γδ T cells, and dendritic cells. By augmenting ADCC, the antitumor activity of mAbs can be significantly increased. Currently, identifying and developing therapeutic agents that enhance ADCC is a growing area of research. Combining existing tumor-targeting mAbs and ADCC-promoting agents that stimulate effector cells will translate to greater clinical responses. In this review, we discuss strategies for enhancing ADCC and emphasize the potential of combination treatments that include US Food and Drug Administration-approved mAbs and immunostimulatory therapeutics. Read the original article here: http://www.dovepress.com/enhancement-of-antibody-dependent-cell-mediated-cytotoxicity-a-new-era-peer-reviewed-article-ITT

http://wn.com/Combination_therapies_in_cancer_treatment_–_Video_abstract_ID_61292_

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This Week in Global Health - episode 2

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Duration: 15:14
Updated: 06 Sep 2014
author: Global Health with Greg Martin

This Week in Global Health, episode 2 focusses on vaccines and immunisation. To get the Show Notes after each episode (including links to webpages) please subscribe to our newsletter: http://bit.ly...

http://wn.com/This_Week_in_Global_Health_-_episode_2

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Review of B cells, CD4+ T cells and CD8+ T cells

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Duration: 11:07
Updated: 19 Feb 2010

Review of B cells, CD4+ T cells and CD8+ T cells More free lessons at: http://www.khanacademy.org/video?v=xaz5ftvZCyI

http://wn.com/Review_of_B_cells,_CD4+_T_cells_and_CD8+_T_cells

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T cell development in the thymus

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Duration: 5:13
Updated: 25 Aug 2014
author: Immunology Toronto

This short video describes how T cells are made in the thymus. The immune system, and T cells, play an important part to recoginize and clear pathogens from ...

http://wn.com/T_cell_development_in_the_thymus

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POSSIBLE CURE FOR BALDNESS

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Duration: 0:47
Updated: 07 May 2014
author: IMPEACH BALDNESS

There is nothing that strikes fear in a man like the prospect of losing his hair. This sign of age for many men, however, may have finally met its match. Whi...

http://wn.com/POSSIBLE_CURE_FOR_BALDNESS

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Gamma Delta T-Cells

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Duration: 9:29
Updated: 18 Nov 2014

http://www.aklectures.com/lecture/gamma-delta-t-cells https://www.facebook.com/aklectures The website organizes the videos into clear and structured chapters that you can use to watch the videos in sequential and logical order as taught by most educational institutions. Each lecture contains a description along with a customized comment section that you can use to ask questions regarding the topic. Posting questions on the site allows us to answer them much quicker than on YouTube. This site was created for the purpose of providing students access to a quality education in the sciences and we are continually working on improving the website's functionality and features. http://www.aklectures.com

http://wn.com/Gamma_Delta_T-Cells

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がん複合免疫細胞療法

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Duration: 13:48
Updated: 15 Jul 2014
author: h2ojp

5種類の免疫細胞NKT・NK・γδ（ガンマデルタ）Ｔ・キラーT細胞・樹状細胞を培養・活性化し治療に使います。お問合せはせんしんクリニックまで・・・相談料無料です。お問合せの際Youtubeを見たと言ってお問合せください。

http://wn.com/がん複合免疫細胞療法

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T cell

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Duration: 22:40
Updated: 26 Jul 2014

T cells or T lymphocytes are a type of lymphocyte (itself a type of white blood cell) that play a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). There are several subsets of T cells, each with a distinct function. This video is targeted to blind users. Attribution: Article text available under CC-BY-SA Creative Commons image source in video

http://wn.com/T_cell

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White blood cell

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Duration: 15:12
Updated: 14 Jul 2014
author: Audiopedia

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in defending the body against both infec...

http://wn.com/White_blood_cell

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White blood cell

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Duration: 17:55
Updated: 29 Apr 2014
author: Frank Eckstein

This is a synthesized speech reading of the Wikipedia article "White blood cell" and is intended primarily for blind and visually impaired individuals who ca...

http://wn.com/White_blood_cell

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Innate immune system

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Duration: 27:55
Updated: 01 Oct 2014

The innate immune system, also known as non-specific immune system and first line of defense, is a subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner. This means that the cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components. The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms. This video is targeted to blind users. Attribution: Article text available under CC-BY-SA Creative Commons image source in video

http://wn.com/Innate_immune_system

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CD1-MR1 in beautiful Lorne, Australia

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Duration: 1:29
Updated: 10 Dec 2014

www.CD1-MR1-2015.org Welcome to our meeting! Unlike MHC molecules that present peptides to T-cells, CD1 and MR1 present lipid and metabolite-based antigens for αβ and γδ T-cell surveillance. Our meeting focuses on the biology of CD1 and MR1, and the T-cells that respond to antigens presented by these molecules. Over the last few years, the field has progressed markedly, with the identification of new lymphocyte populations, new antigens, and a greater appreciation of the role that these components play in the immune system. Our meeting will explore the basic mechanisms of T-cell activation by these unusual antigens, the development and function of the cells involved, and how such information can be ultimately harnessed for therapeutic benefit. We have an outstanding array of international and national speakers, and we will encourage active participation of early career researchers, with great science, terrific food and entertainment, all in a spectacular beach location. We sincerely hope you can join us for what we hope will be a memorable meeting. Regards, Jamie, Jim and Dale

http://wn.com/CD1-MR1_in_beautiful_Lorne,_Australia

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photo: AP / Laurent Cipriani

Investigating police officers work outside the plant where an attack took place, Friday, June 26, 2015 in Saint-Quentin-Fallavier, southeast of Lyon, France.

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France beheading: Man decapitated, several hurt as terrorists with Islamic flag attack gas factory

The Irish Times

26 Jun 2015

A decapitated head has been found posted on the gate at the entrance to a gas factory in south-eastern France which came under attack from terrorists this morning, security officials said. Police sources said the decapitated head was found at the site along with a flag bearing Islamist inscriptions. Local newspaper Le Dauphine said the head was also covered in Arabic writing ... He said they attacked the factory “using gas canisters”....

photo: AP / Michel Euler

A police officer guards the road leading to a plant where an attack took place in Saint-Quentin-Fallavier, southeast of Lyon, France, Friday, June 26, 2015.

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Terrorist Attacks Will Continue to Soar and Here's Why

WorldNews.com

26 Jun 2015

Article by WN.com Correspondent Dallas Darling. The world must come to terms with hard truths instead of pleasant sounding euphemisms and soundbites ... Unlike the U.S ... Coupled with mindless policies, the explosion of individual, tribal, stateless and state-sponsored acts of terrorism will continue to soar ... But even progressive political and military ideas or modern human nature are extensions of the historical past....

photo: AP / Mary Altaffer

New York State Department of Corrections Officers and a forest ranger, back, search a barn in Owls Head, N.Y. for convicted murderers Richard Matt and David Sweat, Friday, June 26, 2015.

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One New York prison escapee killed, one being pursued: reports

Penn Live

26 Jun 2015

One of the two New York prison escapees has been shot and the other is being pursued, according to a report from CNN ... Here's more from the Buffalo News.  ... ....

photo: AP / Chuck Burton

Charleston, S.C., shooting suspect Dylann Storm Roof, center, is escorted from the Sheby Police Department in Shelby, N.C., Thursday, June 18, 2015.

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I Could Have Been Like Dylann Roof

WorldNews.com

25 Jun 2015

Article by WN.com Correspondent Dallas Darling. American citizenship was tragically defined on the exclusionary principles of racism, slavery and genocide. It is an identity that still shapes many Americans while reinforcing institutional boundaries. As for me, it made blacks invisible in imagining an equal and unified community ... Indeed, my first college roommate (decided by the coaching staff) was a young black athlete my age....

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New Fuel Cell Installation Happening at Bridgeport’s Green Energy Park (City of Bridgeport, CT)

Public Technologies

27 Jun 2015

6/26/2015 - New Fuel Cell Installation Happening at Bridgeport's Green Energy Park ... With a foundation in place, the fuel cell's components have been installed. Green Energy Park, which is a clean energy project in collaboration with United Illuminating (UI), will include 9,000 solar panels and a 2.8 Mw AC Fuel Cell facility on an old and currently unused dump ... Come fall, the fuel cell will be complete and producing energy....

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BMC's disaster management cell set for an overhaul

DNA India

27 Jun 2015

The disaster management cell of the Brihanmumbai Municipal Corporation is set to undergo a major overhaul. The cell was in urgent need ......

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Addressing Alzheimer’s (Trinity University)

Public Technologies

27 Jun 2015

Cabrera is working in the lab of Trinity biology professor James Roberts to increase understanding of the disease by studying astrocytes, or nurse cells, of mice neurons. Nurse cells are responsible for repairing the neuron, but as the cells age, their effectiveness weakens, resulting in the debilitating degeneration that is Alzheimer's ... In earlier research, Roberts discovered that ApoE is not present in aged cells....

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New light switches for neurons advance brain research (The University of Texas Health Science Center at Houston)

Public Technologies

27 Jun 2015

HOUSTON - (June 26, 2015) - Light switches for neurons have made enormous contributions to brain research by giving investigators access to "on switches" for brain cells ... Optogenetics is based on genetic targeting to make cells controllable with light ... By pointing a light, researchers can activate brain cells and map their connections with other brain cells and study the physiological functions they perform....

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Gadag police launch hunt to nab Dingaleshwar Swami

The Hindu

27 Jun 2015

The Gadag Police have launched a hunt to nab him ... Yet to be traced ... However, he has switched off his cell phone and has remained untraceable so far,” Superintendent of Police of Gadag K.T ... He said that the swami’s cell phone indicated that he was in Balehosur on the day of the group clash ... ....

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Mother sues Travis County, sheriff over son’s suicide

Austin American Statesman

27 Jun 2015

22, 2013, and hanged himself six months later in his cell using strips of his bed sheets as a noose, according to a lawsuit filed Friday by his mother, Modena Frye-Patch ... Jhane Frye was placed in a single-cell “where he had easy means to kill himself,” like non-suicide resistant sheets and a two-person metal bunk bed with holes through which he was able to tie the noose, the lawsuit said....

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Targeted therapy, 3-D mammograms are new treatments for breast cancer

The Miami Herald

27 Jun 2015

Nancy Tafoya was diagnosed with breast cancer in February 2014 ... Because they single out the mutations or pathways that cause cancer cells to grow, they selectively kill the cancer cells and leave healthy tissue, which is often damaged by chemotherapy, unaffected ... Slingerland’s lab is also trying to understand how a specific gene activates cancer stem cells, and the molecular causes of breast cancer seen in obese and overweight women ... ....

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Less is more: Tibetans thrive on 'roof of the world' due to missing genome, study suggests

South China Morning Post

27 Jun 2015

This genetic mutation stabilised their red blood cell count, thus keeping altitude sickness, and more deadly side effects linked to great heights, at bay, the scientists believe ... Usually, red blood cells spike at higher elevations, an emergency response that increases the lungs’ ability to absorb oxygen from the air ... Data analysis showed that the mutation caused the deletion of a specific genome section near the gene EPAS1 ... ....

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New York prison escapee killed by police, accomplice still at large

Yahoo Daily News

27 Jun 2015

By Pete DeMola ... In making their escape three weeks ago, Matt and Sweat cut through the walls of their adjoining cells and sneaked along the catwalk to a steam pipe, slithered through the pipe and popped out of a manhole outside the prison walls ... Palmer also let the men slip behind their cell walls onto a prison catwalk to hide contraband and alter electrical wiring so they could cook in their cells, according to court documents....

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Escaped killer is fatally shot in New York

Lexington Herald-Leader

27 Jun 2015

For all the intricate planning that allowed them to break out of their cells at the Clinton Correctional Facility in Dannemora, N.Y., the killers made it only about 40 miles from the prison’s imposing walls, moving between remote hunting cabins under the cover of dense woods ... The men, who had adjoining cells, each cut through the walls of ......

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New York prison escapee believed killed in shootout, accomplice flees

Reuters

27 Jun 2015

MALONE, N.Y ... (0030 GMT on Saturday) ... During their escape, Matt and Sweat cut through the walls of their adjoining cells and sneaked along the catwalk to a steam pipe, slithered through the pipe and popped out of a manhole outside the prison walls ... Palmer also let the men slip behind their cell walls onto a prison catwalk to hide contraband and alter electrical wiring so they could cook in their cells, according to court documents ... X. ....

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Sights, sounds from Cincinnati police officer’s funeral

Dayton Daily News

27 Jun 2015

Those who couldn’t attend Sonny Kim’s funeral service lined the streets from the Cintas Center to the Gate of Heaven Catholic Cemetery ... When the white hearse appeared again, the crowd started clapping ... “They, sadly, know the risks ... No cameras, no cell phones ... Doug Wiesman instructed the mourners to put away their cameras and turn off their cell phones. He said no one wanted to be the person whose cell phone rang during the funeral ... ....

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Donald Trump Kicks Univision Off His Golf Course, Publishes Jorge Ramos’ Personal Phone Number

The Inquisitr

27 Jun 2015

In an Instragram post, he also revealed the personal cell phone number of Jorge Ramos, the television network’s high-profile, Emmy-winning news anchor ... He also told his counterpart to close the gate between the two properties ... Trump’s letter to Univision contained this postscript ... However, inform them that should I become President, those days are over ... Now deleted, it contained Ramos’ personal cell phone number ... ....