Anthony Tupou (born 1 March 1984 in Newcastle, New South Wales) is an Australian professional rugby league footballer for the Cronulla-Sutherland Sharks of the National Rugby League. An Australian international and New South Wales State of Origin representative second-row forward, he previously played for the Sydney Roosters. His younger brother is fellow NRL player Ben Tupou.

Tupou made his first-grade debut in 2004 against the South Sydney Rabbitohs. In the September 2004 issue of Big League magazine, after making his debut with the Roosters, Tupou claimed that growing up his favourite player to watch was Queensland legend Mal Meninga. He also claimed that the biggest influence on his football was his father and his club coach Ricky Stuart. At the end of that season he played for the Roosters from the interchange bench in their 2004 NRL grand final loss to cross-Sydney rivals, the Bulldogs.

In 2005, Tupou made his representative début in the City vs Country Origin for the Country NSW team.