Buddhism and science have increasingly been discussed as compatible, and Buddhism has entered into the science and religion dialogue. The case is made that the philosophic and psychological teachings within Buddhism share commonalities with modern scientific and philosophic thought. For example, Buddhism encourages the impartial investigation of Nature (an activity referred to as Dhamma-Vicaya in the Pali Canon) — the principal object of study being oneself. Some popular conceptions of Buddhism connect it to discourse regarding evolution, quantum theory, and cosmology, though most scientists see a separation between the religious and metaphysical statements of Buddhism and the methodology of science.^{[citation needed]}

Buddhism has been described by some as rational and non-dogmatic, and there is evidence that this has been the case from the earliest period of its history, though some have suggested this aspect is given greater emphasis in modern times and is in part a reinterpretation. Not all forms of Buddhism eschew dogmatism, remain neutral on the subject of the supernatural, or are open to scientific discoveries. Buddhism is a varied tradition and aspects include fundamentalism, devotional traditions, supplication to local spirits, and various superstitions. Nevertheless, certain commonalities have been cited between scientific investigation and Buddhist thought. Tenzin Gyatso, the 14th Dalai Lama, in a speech at the meeting of the Society for Neuroscience, listed a "Suspicion of absolutes" and a reliance on causality and empiricism as common philosophical principles shared between Buddhism and science.