Prilep (Macedonian: Прилеп [ˈpriːlɛp] ( listen)) is the fourth largest city in the Republic of Macedonia. It has a population of 66,246 citizens. Prilep is known as "the city under Marko's Towers" because of its proximity to the towers of Prince Marko.

The name of the city in different languages is:

Prilep covers 1,675 km² (647 sq mi) and is located in the northern Pelagonia plain, in southern Macedonia. Prilep is the seat of a municipality with the same name (Prilep municipality) and is accessed by the M5/E65. It is only 128 km (80 mi) (airline) from the capital Skopje, 44 km (27 mi) from Bitola, and 32 km (20 mi) from Kruševo.

Prilep is a center for high-quality tobacco and cigarettes and the metal processing, electronics, timber, textiles, and food industries. The city also produces a large quantity of Macedonian Bianco Sivec (pure white marble).

Tobacco is one of Prilep's traditional cash crops and prospers in the Macedonian climate. Many of the world's largest cigarette makers, such as Marlboro, West and Camel use Prilep's tobacco in their cigarettes after it is processed in local factories such as Tutunski kombinat Prilep. A Tobacco Institute is established in the city in order to produce new types of tobacco and it was the first example of applying genetics to agriculture in the Balkans.^{[citation needed]}.