Factor IX (or Christmas factor) (EC 3.4.21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to hemophilia..
Factor IX is produced as a zymogen, an inactive precursor. It is processed to remove the signal peptide, glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway) to produce a two-chain form where the chains are linked by a disulfide bridge. When activated into factor IXa, in the presence of Ca2+, membrane phospholipids, and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa.
Factor IX is inhibited by antithrombin.
Factor IX expression increases with age in humans and mice. In mouse models mutations within the promoter region of factor IX have an age-dependent phenotype.
Factors VII, IX, and X all play key roles in blood coagulation and also share a common domain architecture. The factor IX protein is composed of four protein domains. These are the Gla domain, two tandem copies of the EGF domain and a C-terminal trypsin-like peptidase domain which carries out the catalytic cleavage.
Now go ahead and humor me if you will.
I want you to give me one good god damn reason why I can't bring my dog into this store.
He weighs less than ten pounds, has all his shots, and besides, he's chilling in the cart.
My fucking dog has fucking papers.
Did you not see all the people whose day was made brighter by me bringing my dog into your store?
Look at this guy getting all worked up for six dollars an hour getting in an argument with me over this cute ass dog while following somebody else's orders.
GET THE FUCK OUT OF MY FACE! And I might let you play with my dog.
Ah now he's calling security over here.
Well what the fuck do they care?
They don't like you anymore than I do.
Here buddy, why don't you go ahead and read this.
He reads the official document, smiles and apologizes.
The paperwork tells him that I require a service dog for my mental instability.
That's right. "Mental instability."
After my fifteen minute hell raising with this kid he needed no further proof.
Just because Dr. Cheeseman tells him I'm insane, this kids gonna believe it.
Well don't believe everything ya read kid. Cause I forged that fucking piece of paper in the first place!
Oh now I got this piece of shit telling me I can't walk around in his gas station without my shoes on.
Why?
Because of sanitary purposes. That's right, "sanitary purposes."
Has he not seen how dirty these fucking floors are?
If anyone's gonna have a problem with the level of sanitation in this place it's gonna be me.
I'm walking around on these crusty ass floors in my bare feet.
No shirt. No shoes. No service.
GET THE FUCK OUT OF MY FACE!
Me and my barefooted friends aren't stepping another barefooted fucking foot in this establishment.
And Yes, this is a service dog. I have his paperwork right here.
I love these snub-nosed beer drinkers who refuse to drink a single solitary domestic beer due to the fact that the United States puts harmful chemicals in all their domestically bottled brew that causes them, the drinker, to feel like shit.
Does this sound as stupid to you as it does to me?
If they're that concerned about the well-being of their body then what the fuck are they doing drinking alcohol in the first place?
And you're telling me you actually think they pay the international shipping rates from Ireland to the U.S. just so that you can have your four pack of Guinness Extra Dry Stout?
NO! They do not!
They bottle and brew that shit in Michigan, the state with the highest contribution of pollutants in the U.S.
I close my eyes and I say goodnight
I open up everything is all right
I pull my hair back get it back real tight
I'm ready now for when the savages fight
I hit your face and I drop you to the floor
All the other pussies running out the fucking door
The cops are here and they raping all the whores
The tear gas is burning and I want some more
The sky's on fire tonight
My fault it is not mine
I see no guiding light
The sky's on fire tonight
The sky's on fire tonight
The kids are screaming and running away
The sounds of life are starting to fade
Pain and joy are trying to escape
Life and death just happen this way
The smoke fades away and all are gone
The parents stare wondering what they did wrong
Minds are pacing and faces run long
The only thing that remains is this song
The sky's on fire tonight
My fault it is not mine
I see no guiding light
I heard Jesus smoked weed
I heard Jesus smoked weed
Was the holy man from Galilee
Well i heard jesus smoked weed
No place to call home not a thing to eat
JC and his apostles loved to chief
They roamed around the land and tried to teach
Preached about the gospel and THC
Now all the little kids is smoking weed
They all be swinging stoned and free
Why is all the children toking trees?
'Cause they all heard that Jesus smoked weed!
Don'tcha wanna be like Jesus?
Don'tcha wanna be like Jesus?
Don'tcha wanna be like Jesus?
Don'tcha wanna be like Jesus?
Don'tcha wanna be like Jesus?
Don'tcha wanna be like Jesus?
Don'tcha wanna be like Jesus?
I heard Jesus smoked weed.
I heard Jesus smoked weed.
Was the holy man from Galilee.
I heard Jesus smoked weed.
Not a place to call home, not a thing to eat.
(No thing to eat!)
JC and his apostles loved to chief.
(They loved to chief! Smokin’ it day and night!)
They roamed around the land and they tried to teach.
(Stoned trying to teach.)
They preached about the gospel and THC.
(THC)
Now all the little kids is smoking weed.
(They all be smoking weedy weed.)
They all be swinging stoned and free.
(Swinging stoned and free yeah)
Now why’s all the children toking trees?
(Toking them trees all night)
‘Cause they all heard that Jesus smoked weed!
Don’t you wanna be like Jesus?
Don’t you wanna be like Jesus?
Don’t you wanna be like Jesus?
live in a duplex.
a big old house in a big old town.
split down the middle.
we got the plywood walls nailed over the doorways.
basement connected.
nailed up with wood.
they say he cooked meth in the basement next door.
they say he cooked meth in the basement next door.
twas the one right after nine oh nine.
twas the one the papers didn’t write.
paid in cash.
moved into a basement full of trash.
cereal boxes and a mattress hidden behind a wall.
they say he cooked meth in the basement next door.
had jars of semen in the basement next door.
had jars of urine and feces in the basement next door.
they say he cooked meth in the basement next door.
livin’ in a duplex.
a big old house in a big old town.
split in half down the middle.
plywood walls nailed over the doorways.
basement connected.
nailed up with wood.
they say he cooked meth in the basement next door.
yeah, I hear he cooked meth in the basement next door.
twas the one right after nine oh nine.
twas the one the papers didn’t write.
they say he cooked meth in the basement next door.
had jars of semen in the basement next door.
had jars of urine and feces in the basement next door.
Ha ha ha ha ha ha ha….
Ugghhh…
Ladies and gentlemen!
Boys and girls of all ages!
Let’s give a big round of applause,
On the flaming trapeze,
To Mister Stephen Glover!
A-Ha ha ha ha ha!
Here we go!
This boy had a vision,
Was gonna see it ‘til the end.
Was gonna go to Harvard,
But became a clown instead.
He put his thumb out with grace,
To find a ride to a school.
That would let him paint his face,
And teach him to be a fool.
All right, come on now!
Oh yeah!
Hand me that bottle!
This boy hit the bottle,
‘Cause clowns, they ain’t no saints.
He started using a camera,
And he threw away his paints.
Bottle rockets in his asshole,
And fire in his hair.
He’ll do whatever is funny,
‘Cause Steve-O, he don’t get scared.
Well, except for one time…
Oh no…
Oh man…
You knew this was coming.
All right, I want every single one of you guys,
If you’re hearing this,
If you’re in the audience or in your car,
I want you to sing along to this part.
‘Cause this here is the representation of a moment…
P-C-P SAVED MY LIFE!!! X4
Now with all the good times,
Come the bad.
But what we have to pay attention to,
And focus on,
Is that the good times outweigh the bad.
And that’s what’s most important.
And that’s why we do what we do!
He’ll be your human dartboard,
Or your human urinal.
He’s the human of all humans,
And that ain’t normal.
Throw your panties on the stage,
And he’ll staple ‘em to his chest.
Be careful to fall in love,
Or he’ll set fire to your breasts.
He went to the jungle,
Conquered all he could find.
And if our hero died,
We would’ve seen it on prime time.
I don’t know much about life,
But one thing that I know.
The world would be a better place,
If we lived like Steve-O!
I don’t know much about life,
But one thing that I know.
The world would be a better place,
If we lived like Steve-O!
And this,
Is why we love you!
Forever!
He let Val Kilmer,
Blow fire off his chin.
He even had the balls,
To jump off the London bridge!
Got locked up in Sweden,
For chronic in his caboose.
Gave ‘em all he had,
Just to keep them badass shoes!
If you’ve got a knife cut,
You don’t need no stitches.
Grab a bottle of glue,
And let ol’ Uncle Steve-O fix it!
Let’s not forget,
Why this guy stopped skating.
It’s ‘cause of a bad ass motherfucker,
Named RYAN SIMONETTI!
That guy is CRAZY!!!
Stapling of his balls to the inside of his legs.
Now the butterfly is illegal in forty-nine states!
Taking shots of vodka straight into his vein.
What this guy pulls would drive another man insane!
David Blaine shared his magic with the quarter trick.
Steve-O showed us on the Internet!
Got a little club for the disease infected.
Where everybody has sex unprotected!
Now you say that you only get a tattoo,
If you’re pretty sure that everybody’s gonna laugh at it.
Well I guarantee you that if you get a Bone Fags tattoo,
Everybody is gonna laugh at you!
All right Steve-O!
This one is for you!
For all the times you’ve made us laugh,
Now we’re trying to return the favor.
I don’t know much about life,
But one thing that I know.
The world would be a better place,
If we lived like Steve-O.
I don’t know much about life,
But one thing that I know.
The world would be a better place,
If we lived like Steve-O.
Now Hunter couldn’t do it,
But you did it.
All he had was a quote,
Now you’ve got a video.
P-C-P,
Saved my life! X19
Stephen Glover,
One evening as the moon came out and we had a joint a burning
Down the alley came a punk rocker, and he said "dudes I'm not turning
"I'm headed for a town that's far away, does my face look like I’m clownin’
"So come with me, we'll go and see the Punk Rock Candy Mountains"
In the Punk Rock Candy Mountains there's a show that lasts all night
And they never charge a cover and you’ll never see a fight
The taxis drive ya around for free and no one gets in your way
No bloods or G’s and no hippies
And no one clings to their one night flings
In the Punk Rock Candy Mountains
In the Punk Rock Candy Mountains you can never break your legs
And for the price of a forty ounce you can buy yourself a keg
Cause stores are made for you to loot and ya never gotta pay
Oh I'm bound to go where there ain't no snow
Just the kind that you put up your nose
In the Punk Rock Candy Mountains
In the Punk Rock Candy Mountains you’ll never see a clock
And the little streams of PBR come a-trickling down the rocks
The shows are never-ending and the bands are all unsigned
There’s a joint for you, go head take two
Cause you can always do what you wanna do
In the Punk Rock Candy Mountains
In the Punk Rock Candy Mountains the jails are made of tin
And you can walk right out of them as soon as you are in
There ain't no fuckin’ assholes, no douche-bags, cops or dicks
I'm a-goin' to stay where you drink all day
Where they hung the jerk that invented work
In the Punk Rock Candy Mountains
In the Punk Rock Candy Mountains you’ll never go to court
There are no processing fees and no unpaid child support
The skate-parks are full of life and ya never wait in line
No falsification they call taxation
There’s no violation of fuckin’ probation
In the Punk Rock Candy Mountains
When I was just a kid I couldn't wait to be a man.
Now that I'm a man I'll be a kid as long as I can.
I took everything I ever had and I buried it in the ground.
And when I dug it up I couldn't believe what I had found.
Small was big and time was slow and I forgot what I once was.
And everything we ever did was for the reason just because.
I did what I was told to do and taught all that I know.
And I buried my dreams in the ground and decided to let em go 'cause...
We're gonna live - FOREVER!
We live our lives until we choose to die.
And when we die, gonna die - TOGETHER!
And let know happy times be cast aside.
I've worked many jobs and I quit 'em all and I'm always moving on.
'Cause the feeling I get when I do the same shit it makes these days seem wrong.
Now I'm running around with my head cut off and doing what you say.
I've done it every day and all your way working for your shitty pay.
We're gonna live - FOREVER!
We live our lives until we choose to die.
And when we die, gonna die - TOGETHER!
And let know happy times be cast aside.
But I keep my head up and I keep looking forward 'cause I know what I'm here to do.
I'm gonna live my life and walk with pride and I'm doing it all for you!
They can't take it away 'cause I do what I say and I'm doing it till the end.
I'll wrap my arms around you and always help you through and we can make it with just a friend!
We're gonna live - FOREVER!
We live our lives until we choose to die.
And when we die, gonna die - TOGETHER!
And let know happy times be cast aside.
We're gonna live - FOREVER!
We live our lives until we choose to die.
And when we die, gonna die - TOGETHER!
Drinking beer and breaking windows
Life seems kind of simple
As we're wasting all this away
Went to the store overdraw my account
It seems so avoidable
As I'm making my today
Scratching my balls not knowing what crabs are
A condom wouldn't have stopped it
But I'm fucking strangers anyway
Driving my car straight through the glass
It seems so illogical
But fuck, it's in my way
Living my life. My entire life today.
Doing it all before time gets in my way.
Living my life. All of it today.
Doing it all before time gets in my way.
I'm all wasted I gotta get outta here
No cash for a taxi
I got sirens in my rear view mirror
Eviction notice and I just got fired
I'm sure I could've stopped it
But hey fuck it, I was having a good time
Tattoo infected and I Ripped the scab off
It could have looked cooler
But it looks cooler now
Got fish skin clogging up my sink
Got no disposal but
It covers up the smell of beer
Living my life. All of it today.
Doing it all before time gets in my way.
Living my life. All of it today.
People people people try to get in my face
Say, "Who the fuck are you get outta my way"
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Swallow your bullets and drink your mace
Now who the fuck are you get outta my face!
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Run run run gonna chase you down
When the cops comin' at ya get outta town!
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
People are fucked, gonna fuck you too
When the cops come around you know what I do.
I jump the wall!
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
Jump The Wall, Jump The Wall
If I keep doing this until the end of time then I’ll feel good even when I die.
I’ll try not to lust and I’ll try not to lie and I’ll feel good even when I die.
I’ll rattle my body and I’ll shake it around
and I’m gonna do it ‘till my knees go out.
I jump up and down and I twist and I shout.
And I’m gonna sing when I hear that sound.
I take one step and I leave one behind.
There’s no tellin’ what you or I may find
if we keep on searchin’ and forget about the time.
Then we’ll all stand together in a neverending line
with the smiles of laughter and the smiles with tears.
It’s okay ‘cause we all have fears.
We’ll just keep on rhymin’ and grindin’ those gears
and when our moment comes we’ll remember these years.
And I’ll feel good even when I die
‘cause I know that I was livin’ with pride.
And I’ll feel good even when I die
‘cause ya know that I was livin’ it with pride.
[another verse comin‘ at ya!]
I wake up today and I step outside.
There’s surprises I hide and surprises I find.
I never stop lookin’ but I never look behind
‘and the direction I go is the way of the mind.
’Cause my mind is turnin’ and it never stops learning.
Begins where it ends but it’s never returning.
And the words that I’m singing always make their own meaning
and you can’t believe what it is that you’re reading.
The book of our life it doesn’t start or end.
The chapters flow but they never begin.
The pages break but you still got a pen
so just keep on writing it again and again
and I’ll feel good even when I die.
‘Cause ya know that I am living with pride.
And I’ll feel good even when I die,
Hear the ghost clock ticking in our head
With a tick tock it's over when we're dead
Hear the ghost clock ticking in our head
With a tick tock it's over when we're dead
Walk till our legs won't take us there
Then this is where we'll be
Said we'll walk till our legs won't take us there
Then this is where we'll be
When we hear the ghost clock
Sticking in our head
With a tick tock it'll be over when we're dead
Hear the ghost clock sticking in our head
With a tick tock it'll be over when we're dead
With a ghost clock ticking in our head
With a tick tock it'll be over when we're dead
Walk till our legs won't take us there
Then this is where we'll be
Said we'll walk till our legs won't take us there
Then this is where we'll be
When we hear the ghost clock
Ticking in our head
With a tick tock
It'll be over when we're dead
Hear the ghost clock sticking in our head
With a tick tock it'll be over when we're dead
We'll hear the ghost clock ticking in our head
With a tick tock it'll be over when we're dead
Walk till our legs won't take us there
Then this is where we'll be
Said we'll walk till our legs won't take us there
Then this is where we'll be
When we hear the ghost clock
Ticking in our head
With a tick tock
All the little people are walkin’ down the street.
All the little people and they don’t know how to meet.
all the little people and their heads are looking down.
all the little people walking on their little ground.
Everytime I run around I end up where i’m comin’ from.
And everytime I turn around I don’t know what it is i’ve done.
Everytime I run around I end up where i’m comin’ from.
everyone is walkin’ and they don’t know who they are.
everybody talkin’ but they don’t know what they are.
everybody lookin’ down but no one wants to make a sound.
‘cause everyone is lookin’ round but doesn’t want to tear it down.
Everytime I run around I end up where i’m comin’ from.
And everytime I turn around I don’t know what it is i’ve done.
all the little people and they walkin’ kind of funny.
all the little people and they don’t they got no money.
Everytime I run around I end up where i’m comin’ from.
And everytime I turn around I don’t know what it is i’ve done.
LaLaLa.
all the little voices and the people do not hear.
all the little people here and all the little people there.
and all the little people to never to be seen.
Woke up today with a brain like this
Brain like this, yeah, a brain like this
Smoke them cigarettes and drink that gin
Voice was like this, like this, like this
Gonna get worse 'cause I'm doing it again
I'll do it again and again and again
I can barely talk and I'm losing my friends
But I'm gonna do it again and again
Swallow sandpaper, I'm all right
Scream real loud and shout all night
Like a broken megaphone, I'm all right
Scream like a dog and bark all night
I started talking today
My voice is sounding this way
What else can I say?
This band is fucking gay
My mouth is bone dry
My voice is all haggard
I'm still walking funny with that
Drunken swagger
Yeah
Woke up today with a brain like this
Brain like this, yeah, a brain like this
Smoke them cigarettes and drink that gin
Voice was like this, like this, like this
My mouth is still dry
My voice is more haggard
Tell the boss I died
Take advantage of this matter
Drink a glass of water
It turns into sand
I'm throwing up into the glass in my hand
Pour another shot
Take it like a man
Keep this voice as long as I can
Woke up today with a brain like this
Brain like this, yeah, a brain like this
Smoke them cigarettes and drink that gin
One evening as the moon came out and we had a joint a burning
Down the alley came a punk rocker, and he said "dudes I'm not turning
"I'm headed for a town that's far away, does my face look like I’m clownin’
"So come with me, we'll go and see the Punk Rock Candy Mountains"
In the Punk Rock Candy Mountains there's a show that lasts all night
And they never charge a cover and you’ll never see a fight
The taxis drive ya around for free and no one gets in your way
No bloods or G’s and no hippies
And no one clings to their one night flings
In the Punk Rock Candy Mountains
In the Punk Rock Candy Mountains you can never break your legs
And for the price of a forty ounce you can buy yourself a keg
Cause stores are made for you to loot and ya never gotta pay
Oh I'm bound to go where there ain't no snow
Just the kind that you put up your nose
In the Punk Rock Candy Mountains
In the Punk Rock Candy Mountains you’ll never see a clock
And the little streams of PBR come a-trickling down the rocks
The shows are never-ending and the bands are all unsigned
There’s a joint for you, go head take two
Cause you can always do what you wanna do
In the Punk Rock Candy Mountains
In the Punk Rock Candy Mountains the jails are made of tin
And you can walk right out of them as soon as you are in
There ain't no fuckin’ assholes, no douche-bags, cops or dicks
I'm a-goin' to stay where you drink all day
Where they hung the jerk that invented work
In the Punk Rock Candy Mountains
In the Punk Rock Candy Mountains you’ll never go to court
There are no processing fees and no unpaid child support
The skate-parks are full of life and ya never wait in line
No falsification they call taxation
There’s no violation of fuckin’ probation
In the Punk Rock Candy Mountains