- published: 05 Aug 2014
- views: 60553
Cancer Immunotherapy - PD-1 and PD-L1
Discovering the PD-1 Checkpoint: Winners of the 2014 William B. Coley Award for Tumor Immunology
PD-1, PD-L1 role in immune system inhibition
PD-L1/PD-1 Pathway: A Security Checkpoint
Immunotherapy - PD-1 and Beyond - Melanoma Education Symposium, Patrick Ott MD PhD
PD-1 and PD-L1 Checkpoint Inhibitor Pathway (Webinar)
Anti–PD-1/PD-L1 therapy of human cancer
The basic biology of PD-1/PD-L1
Anti–PD-1/PD-L1 therapy of human cancer(with sound track)
[CF] P.D. #1 - O COMEÇO !
Dan Chen MD, PhD from Stanford Medical Oncology and Genentech describes brilliantly how our immune system detects cancer cells and how tumors get past our immune system through PD-L1, PD-1, and B7.1 interactions. A must see!!! Brilliant way to understand the effects of checkpoint inhibitors and cancer immunotherapy.
Winners of the 2014 William B. Coley Award for Distinguished Research in Tumor Immunology discuss their contributions to the discovery of the PD-1 immune checkpoint and its role in cancer immunotherapy. Featuring Arlene Sharpe, M.D., Ph.D., of Harvard Medical School; Gordon Freeman, Ph.D., of Dana-Farber Cancer Institute; Tasuku Honjo, M.D., Ph.D., of Kyoto University School of Medicine; and Lieping Chen, M.D., Ph.D., of Yale University School of Medicine. The William B. Coley Award is given annually to scientists who have made important contributions to basic or tumor immunology, and is the highest honor bestowed by the Cancer Research Institute. Photos of Dr. Chen courtesy of Harold Shapiro.
Dr. Patrick Ott, Assistant Orofessor of Medicine at Harvard Medical School, Dana Farber Cancer Center speaks on the future of immunotherapy and clinical trials for metastatic melanoma at the 2013 Melanoma Education Symposium hosted by The Angeles Clinic Foundation and AIM at Melanoma
www.phenopath.com Dr. Allen M. Gown (from PhenoPath) and Dr. Farah Patell-Socha (from Horizon Discovery) presented “PD-1 and PD-L1 Checkpoint Inhibitor Pathway” at 8:00AM (PST) on Thursday, May 5, 2016. Listen to the webinar and learn about: - Mechanisms of PD-1/PD-L1 interactions and the principle behind the use of PD-1 and PD-L1 inhibitors - How data is supporting the use of PD-L1 Immunohistochemical testing in predicting drug response - The different Immunohistochemical assays currently available to assess PD-L1 expression and their challenges and limitations - Development and testing the analytical performance of your PD-L1 assay with precisely defined external controls Check http://phenopath.com/uploads/pdf/pd-l1-22c3-28-8-e1l3n.pdf for more information about anti-PD-L1 antibodi...
PD-L1,a 40kDa type 1 transmembrane protein, is a PD-1 ligand that can deliver inhibitory signals to PD-1+ T-cells to suppress immune responses. PD-L1 is widely expressed in cancer, where it contributes to immune evasion and facilitates tumor growth. Immunotherapy for the treatment of cancer is rapidly evolving from therapies that globally and non-specifically simulate the immune system to more targeted activation of individual components of the immune system. More specifically, therapies that inhibit the interaction between PD-L1, present on the surface of tumor or antigen-presenting cells, and PD-1, present on the surface of activated lymphocytes, are generating much excitement and enthusiasm, even in malignancies that are not traditionally considered to be immunogenic.
Drs. John M. Kirkwood and Antoni Ribas chaired the Perspectives in Melanoma XVII meeting on September 13-14, 2013 in Baltimore, Maryland. This webcast is composed of presentations from though leaders and clinical investigators in melanoma on current and controversial topics in the field and new scientific leads from the bench to the clinic. Follow along to learn about new screening and staging modalities, emerging new management approaches, and clinical trial updates from some of the world's leading investigators in melanoma. Earn accreditation for this activity at the following location: http://elc.imedex.com/elc/activity-search.aspx?search=6917 © 2013 Imedex, LLC.
Anti–PD-1/PD-L1 therapy of human cancer: PD-L1,a 40kDa type 1 trans-membrane protein, is a PD-1 ligand that can deliver inhibitory signals to PD-1+ T-cells to suppress immune responses. PD-L1 is widely expressed in cancer, where it contributes to immune evasion and facilitates tumor growth. Immunotherapy for the treatment of cancer is rapidly evolving from therapies that globally and non-specifically simulate the immune system to more targeted activation of individual components of the immune system. More specifically, therapies that inhibit the interaction between PD-L1, present on the surface of tumor or antigen-presenting cells, and PD-1, present on the surface of activated lymphocytes, are generating much excitement and enthusiasm, even in malignancies that are not traditionally consi...
I'll open up if you make an incision
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Open heart surgery
I was fine at first
Now I assume the worst
When I could overhear
The repercussions of a sad discussion
Another girl in tears
I could've saved here if I only knew better
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Took her apart and put her back together
Open heart surgery
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Even she's begun to understand
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I find a way to get along somehow
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Just take it slow
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I'm on the verge of an emergency
The final blow
Will make me tougher
Until then you will always be
A danger to me
We should've listened to our intuition
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In addition to our suspicions
Only time could tell
With friends like you I get confused
Who needs enemies
We've been here too many times before
Open heart surgery
If girls like you and girls like me
Are really a dime a dozens
Why are we in such a high demand
My mother says it's just a shame you don't come around too often
Even she's begun to understand
Just let me know
What you were thinking
I find a way to get along somehow
Just let me go
Don't leave me hanging
Oh, please don't fail me now
Just take it slow
Don't let me suffer
I'm on the verge of an emergency
The final blow
Will make me tougher
Until then you will always be
A danger to me
A danger to me
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