People (disambiguation)

People is the plural of "person" and may also refer to:

Publications

Music

Albums

Songs

People (James Brown album)

People is the 52nd studio album by American musician James Brown. The album was released in March 1980, by Polydor Records.

Track listing

References

43 Things

43 Things was a social networking website established as an online goal setting community. It was built on the principles of tagging, rather than creating explicit interpersonal links (as seen in Friendster and Orkut). Users created accounts and then listed a number of goals or hopes; these goals were parsed by a lexer and connected to other people's goals that were constructed with similar words or ideas. This concept is also known as folksonomy. Users could set up to 43 goals, and were encouraged to explore the lists of other users and "cheer" them on towards achieving their goals.

The 43 Things website went offline on New Years Day, 2015.

History

43 Things was launched on January 1, 2005, by the Robot Co-op, a small company based in Seattle founded by blogger Erik Benson, Maktub keyboardist Daniel Spils, and former Amazon.com and Microsoft executive Josh Petersen. 43things.com became read-only on August 15, 2014, and shut down permanently January 1, 2015.

Critique

According to "43 Things: A Community Study," 43 Things had two shortcomings: (1) it failed to have a central area containing documentation about the website and (2) it relied heavily upon RSS, which is unfamiliar to a large portion of users. Regardless, it received solid reviews in regards to responsiveness and user suggestion integration.

Mad (Ne-Yo song)

"Mad" is a song by American pop/R&B singer Ne-Yo. It is the third single from his album Year of the Gentleman and was produced by Stargate and himself.

Music video

The video for the song was directed by Diane Martel. It premiered on AOL on November 25, 2008. The video, shot in black and white, presents a narrative wherein Ne-Yo argues with his girlfriend (played by Faune Chambers). After leaving, in an attempt to save a child from a car accident, someone is fatally hit. At the end of the video, it is revealed that the whole time it has been the ghost of Ne-Yo's character singing, and that it was he who was killed. The video to this song is Part 2 to his song Part of the List.

The music video appears to mirror the 1999 American thriller The Sixth Sense from M. Night Shyamalan, in which Bruce Willis plays a psychologist who is shot by an estranged patient of his. Based on how the film was shot and portrayed, Bruce Willis is shown in many situations as if he is there physically, when in actuality he was murdered by his patient, just as how Ne-Yo appears with his girlfriend, seeming to be there physically and that she is ignoring him due to their earlier argument, when he is actually dead.

Mad1

Mad1 is a non-essential protein in yeast which has a function in the spindle assembly checkpoint (SAC). This checkpoint monitors chromosome attachment to spindle microtubules and prevents cells from starting anaphase until the spindle is built up. The name Mad refers to the observation that mutant cells are mitotic arrest deficient (MAD) during microtubule depolymerization. Mad1 recruits the anaphase inhibitor Mad2 to unattached kinetochores and is essential for Mad2-Cdc20 complex formation in vivo but not in vitro. In vivo, Mad1 acts as a competitive inhibitor of the Mad2-Cdc20 complex. Mad1 is phosphorylated by Mps1 which then leads together with other activities to the formation of the mitotic checkpoint complex (MCC). Thereby it inhibits the activity of the anaphase-promoting complex/cyclosome (APC/C). Homolog’s of Mad1 are conserved in eukaryotes from yeast to mammals.

Introduction

In the early 90s, yeast genes were identified which mutations resulted in a defect in mitotic arrest in response to microtubule disassembly (mitotic arrest deficient genes - MAD genes). This cells showed during division no mitotic arrest in the presence of microtubule polymerization inhibitors and were therefore not able to delay cell division. The genes identified included the MAD1, MAD2 and MAD3 genes. They are conserved in all eukaryotes and are involved in a pathway that is active in prometaphase to prevent the premature separation of sister chromatids and constitute the so-called spindle assembly checkpoint(SAC). This checkpoint monitors the status of chromosome attachment to the mitotic spindle and inhibits the metaphase to anaphase transition by preventing the activation of the anaphase-promoting complex/cyclosome (APC/C), and thereby the degradation of cell cycle regulators. Mad1 is in this pathway accumulated at unattached kinetochores and acts as a sensor for unattached kinetochores in this machinery.

Mad2

Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons. The human orthologues of Mad2 (MAD2L1 and MAD2L2) were first cloned in a search for human cDNAs that would rescue the microtubule poison-sensitivity of a yeast strain in which a kinetochore binding protein was missing. The protein was shown to be present at unattached kinetochores and antibody inhibition studies demonstrated it was essential to execute a block in the metaphase-to-anaphase transition in response to the microtubule poison nocodazole. Subsequent cloning of the Xenopus laevis orthologue, facilitated by the sharing of the human sequence, allowed for the characterization of the mitotic checkpoint in egg extracts.

Metaphase-to-anaphase transition

Female (1933 film)

Female is a 1933 Warner Bros. Pre-Code film directed by Michael Curtiz and starring Ruth Chatterton and George Brent. It is based on the novel of the same name by Donald Henderson Clarke.

Plot

Alison Drake (Ruth Chatterton) is the wealthy owner and hard-driving, no-nonsense head of a large automobile company, inherited from her father. Her work has caused her to lose her youthful romanticism, and she has casual affairs with men, including her own employees.

Alison hosts a party at her mansion, but becomes fed up with the men out to either sell her things or marry her for her money. She dresses down and goes to an amusement park, where she picks up a man at a shooting gallery. They have fun together, but he refuses her offer to go home with him.

The next day, they meet again at her factory. To their mutual astonishment, he turns out to be Jim Thorne (George Brent), a gifted engineer she has ordered her underlings to hire away from her competition. Saying that she has no time now, Alison has him come to her mansion that night, supposedly to discuss his plans for the company in detail. She attempts to seduce him, but he rejects her as anything other than his employer.