Antonio D. Perkins (born January 9, 1981) is a former American college and professional football player who was a kick returner and cornerback in the National Football League (NFL) for two seasons during the early 2000s. He played college football for the University of Oklahoma, and earned All-American honors. Perkins played professionally for the NFL's Cleveland Browns.

Perkins was born in Lawton, Oklahoma. He attended Lawton High School, graduating in 2000. He was a letterman in football.

Perkins attended the University of Oklahoma, and played for the Oklahoma Sooners football team from 2000 to 2004. In 47 games with the Sooners, he started 30 times and finished with 125 tackles, one sack, five stops for losses, two forced fumbles, two fumble recoveries and 21 pass deflections. He set the NCAA record for most punt returns for touchdowns in a single game, with three, as well as most punt return yards in a game with 277, against UCLA in 2003. He is tied with Wes Welker and Ted Ginn, Jr. for most punt return touchdowns in a career, in NCAA history, with 8.