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Henry Hallett Dale
Born	(1875-06-09)9 June 1875 London, England
Died	23 July 1968(1968-07-23) (aged 92) Cambridge, England
Nationality	United Kingdom
Fields	Pharmacology, Physiology
Known for	Acetylcholine
Notable awards	Nobel Prize in Physiology or Medicine (1936)

Sir Henry Hallett Dale, OM, GBE, PRS^[1] (9 June 1875 – 23 July 1968) was an English pharmacologist and physiologist. For his study of acetylcholine as agent in the chemical transmission of nerve impulses (neurotransmission) he shared the 1936 Nobel Prize in Physiology or Medicine with Otto Loewi.^[2][3]

Biography[link]

The Nobel Prize diploma of Sir Henry H. Dale, displayed in the Royal Society, London.

Henry Hallett Dale was born in Islington, London, to Charles James Dale, a pottery manufacturer from Staffordshire, and his wife, Frances Anne Hallett, daughter of a furniture manufacturer.^[4][1] Henry was the third of seven children, one of whom (his younger brother, Benjamin Dale) became an accomplished composer and warden of the Royal Academy of Music. Henry was educated at the local Tollington Park College and then The Leys School Cambridge (one of the school's houses is named after him) and in 1894 entered Trinity College at Cambridge University,^[5] working under the physiologist John Langley. For a few months in 1903 he also studied under Paul Ehrlich in Frankfurt, Germany. Also in 1903, Dale assisted Ernest Starling and William Bayliss in the vivisection of a dog, by removing the dog's pancreas and then killing the dog with a knife, which ultimately led to the events of the Brown Dog affair.

Dale received his M.D. from Cambridge in 1909. While working at the University College London he met and became friends with Otto Loewi. Dale became the Director of the Department of Biochemistry and Pharmacology at the National Institute for Medical Research in London in 1914. He was knighted in 1932, receiving the Order of Merit in 1944 and the Knight Grand Cross of the Order of the British Empire in 1948. Dale served as President of the Royal Society from 1940 to 1945. He became a Fullerian Professor of Chemistry at the Royal Institution in 1942. During World War II, he served on the Scientific Advisory Panel to the Cabinet.

In 1904, Dale had married his first cousin Ellen Harriet Hallett and had a son and two daughters.

Research[link]

This section requires expansion.

Although Dale and his colleagues first identified acetylcholine in 1914 as a possible neurotransmitter, Loewi showed its importance in the nervous system. The two men shared the 1936 Nobel Prize for Medicine.

During the 1940s Dale was embroiled in the scientific debate over the nature of signaling at the synapse. Dale and others believed that signaling at the synapse was chemical, while John Carew Eccles and others believed that the synapse was electrical. It was later found that most synaptic signalling is chemical, but there are some synapses that are electrical.

Dale also originated the scheme used to differentiate neurons according to what neurotransmitter they release. Thus, neurons releasing norepinephrine (also known as noradrenaline) are called noradrenergic, neurons releasing GABA are GABAergic, and so on. This scheme is related to Dale's principle (sometimes erroneously referred to as Dale's Law). This principle states that each neuron releases only one type of neurotransmitter. Dale's principle has been shown to be false; since many neurons have been shown to release neuropeptides and amino acids in addition to classical neurotransmitters such as acetylcholine or biogenic amines (Bear, et al. 2001). This finding, that numerous neurotransmtters can be released by the same neuron, is referred to as the "coexistence principle." This phenomenon was most popularized by the Swedish neuroanatomist and neuropharmacologist Tomas Hökfelt, who is considered to be the "Father of the Coexistence Principle."

References[link]

External links[link]

• Sir Henry Dale – Biography. Nobel Foundation.
• Sabbatini, R.M.E.: Neurons and synapses. The history of its discovery. IV. Chemical transmission. Brain & Mind, 2004.
• Fullerian Professorships

Mike Hallett

Born	(1959-07-06) July 6, 1959 (age 52)
Sport country	England
Professional	1980–
Highest ranking	6 (1989/90)
Career winnings	£920,000
Highest break	139
Tournament wins
Ranking	1
Non-ranking	2

Mike Hallett (born July 6, 1959) is an English professional snooker player and television sports commentator.

Career[link]

Hallett was a consistently solid snooker player, but never reached the very top ranks. After winning the national under-16 title in 1975, his world ranking peaked at number six in 1989–90, after his only ranking tournament victory at the 1989 Hong Kong Open in which he beat Dene O'Kane 9–8.

In a semi-final match against John Parrott in the 1988 Benson & Hedges Masters, he recovered from needing four snookers to win the decider, 6–5. However, he lost 9–0 to Steve Davis in the final.

In 1991 he reached the Masters Final again at Wembley where, in the 17-frame match, he surged to a 7–0 lead over Stephen Hendry and missed a pink which would have put him 8–0 ahead. He then moved into an 8–2 lead and needed just one frame to win the tournament (in fact, he had just the pink and black to clear for the match in the eleventh frame, but missed with the rest). Hendry managed to spring a comeback to win the match 9–8. To make matters worse, Hallett returned home to find that his house had been burgled.^[1]

Hallett did reach the quarter-finals of the World Championship twice, but never progressed further than that. His final season on the main tour was in 2004–05, but went on to play in the Pontin's International Open Series.^[2] During his career he won approximately £920,000.^[3]

Recently, Hallett has been commentating on Premier League Snooker for Sky Sports, and all major Snooker events on Eurosport. At the start of the 2011/12 season Hallett has entered PTC1 and after winning his first two matches against Duane Jones 4-3 and Elliot Slessor also 4-3, he played Ronnie O'Sullivan and managed to take two frames in losing 4-2.^[4]

Tournament wins[link]

Ranking tournaments[link]

• Hong Kong Open (1989)

Non-ranking tournaments[link]

• Humo Masters (1991)
• Regal Scottish Masters (1991)

Team events[link]

• Fosters World Doubles (1987) (with Stephen Hendry)
• World Masters Doubles (1991) (with Stephen Hendry)

References[link]

External links[link]

• Mike Hallett at CueTracker.net: Snooker Results and Statistic Database

Roxana Zal (born November 8, 1969) is an American actress.

Zal was born and raised in Malibu, California, the daughter of Maureen and Hossein Zal, a Los Angeles investor.^[1] She was on her High School tennis team. Her first acting role was a guest spot on Hart to Hart at age 12. She has had several other guest roles since then, the most recent being in the show Navy NCIS. She is primarily known for being the youngest winner of a prime-time Emmy Award. She won for Something about Amelia when she was fourteen, in which she played a girl molested by her father (played by Ted Danson). She co-produced and starred in the 1998 independent film, Broken Vessels. She also played a main role of "Tara Matthews" in the 1999 film "Primal Force".

References[link]

External links[link]

• Roxana Zal at the Internet Movie Database
• Roxana Zal at the TCM Movie Database
• Roxana Zal at Yahoo! Movies

This article about an American television actor or actress born in the 1960s is a stub. You can help Wikipedia by expanding it. v t e

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Brent David Fraser (born February 21, 1967) is an American actor and musician. He was born in Bremerton, Washington.

Filmography[link]

Film[link]

• The Chocolate War (1988) .... Emile Janza
• Book of Love (1990) .... Meatball
• Wild at Heart (1990) (as Brent Fraser) .... Idiot Punk
• Class of 1999 (1990) .... Flavio
• Plymouth (1991) (TV) .... Litchfield
• The Can (1994)
• Mixed Blessings (1998) .... Derek
• Broken Vessels (1998) .... Jed
• Farewell to Harry (2002) .... Mickey
• Dead & Breakfast (2004) .... The Drifter
• The Memory Thief (2006) .... Pound Custodian

Television[link]

• The Tracey Ullman Show (1990) episode: "Her First Grownup" - Jimmy
• Dark Skies (1997) episode: "The Last Wave" - Jim Morrison
• Fame L.A. (1997) episode: "Who Do You Love?" - Brent Legget
• The Outer Limits (1998) episode: "The Vaccine" - Graham

External links[link]

• Brent David Fraser at the Internet Movie Database
• Brent David Fraser on Facebook

This article about a United States film and television actor or actress born in the 1960s is a stub. You can help Wikipedia by expanding it. v t e

Christian Kane
Kane in Las Vegas, April 27, 2006
Born	(1974-06-27) June 27, 1974 (age 37) Dallas, Texas
Occupation	Actor, singer/songwriter
Years active	1997–present
Website
www.christiankane.com

Christian Kane (born June 27, 1974) is an American actor and singer/songwriter of Native American descent. He currently stars as Eliot Spencer on the TNT series Leverage. He is best known for his roles in the television shows Angel and Into the West, and the movies Just Married and Secondhand Lions.

He is the lead singer of the country-southern rock band Kane. On December 7, 2010 they released The House Rules, their third album and their debut for record label Bigger Picture Group. The album reached #25 on the Billboard Country Albums chart. The first single from the album, also titled "The House Rules", debuted at #54 on the Billboard Country Songs chart. The second single, “Let Me Go”, was released on July 11, 2011.

Early life[link]

Christian Kane was born in Dallas, Texas. He is of Native American descent^[1] and is a cousin of country singer Branden Hart.^[2] His parents participated in, and met at, the rodeo. The family moved around the South and Midwest because his father was in the oil business and finally settled in Norman, Oklahoma, when Kane was in 8th grade. While growing up in Texas and Oklahoma, Kane was a wrestler and played American Football (as a strong safety) .^[3] He studied Art History at the University of Oklahoma but decided he wanted to be an actor and headed to Los Angeles before finishing the degree.^[4] In LA, he worked at a talent management company where he delivered scripts in exchange for being sent on auditions.^[5]

Career[link]

Acting[link]

Kane with Amy Acker at a signing in Santa Barbara.

Kane landed his first acting role in 1997 as one of the leads in MGM's television series Fame L.A.; in the series he played a country singer who moved to Los Angeles from Kansas. His television roles have included a recurring role in Joss Whedon’s Angel as the lawyer Lindsey MacDonald, the Jerry Bruckheimer produced series Close to Home on CBS, the TNT television film Crossfire Trail in which he appeared alongside Tom Selleck, and he played the role of Abe Wheeler in the Steven Spielberg produced miniseries Into the West.

Kane’s appearances on the big screen include the 20th Century Fox film Just Married and New Line Cinema's Secondhand Lions, as the younger version of Robert Duvall's Hub McCann, he has a scar on his upper lip from an injury he received while filming the movie.^[6] He also appeared in Taxi, Life or Something Like It, the Peter Berg directed Friday Night Lights, and the Warner Bros. baseball film Summer Catch.

In 2007, Kane was featured in the Carrie Underwood music video, "So Small", playing the role of one of the three converging stories.

In 2009, he appeared in the psychological thriller, Hide,^[7] in which he played the lead role of Billy, and The Donner Party which is based on the true story of the Donner Party.

In 2010, he starred in the romantic drama, Not Since You.^[8][9]

Since late 2008, Kane appears on the TNT television series Leverage, which will return for its fifth season next summer.^[10] Kane does his own stunts and fights^[1] as Eliot Spencer, a retrieval specialist who teams up with four other specialists to undo the injustices perpetrated upon the helpless.

Music[link]

In 1997, Christian Kane met Steve Carlson, who had taken over his old job. They started writing songs together, and in 1998, they formed the Southern rock band Kane. They have toured the U.S. as well as England and Germany. The band has self-released two albums, their self-titled debut, Kane, in 2000 and a recording of a live acoustic set, Acoustic Live In London! in 2004.^[11]

The band consists of Christian Kane (lead vocals, guitar), Steve Carlson (rhythm guitar, backing vocals), Jason Southard (lead guitar), Will Amend (bass guitar), and Ryan Baker (drums) and is signed to independent record label Bigger Picture Group (Zac Brown Band, Big Kenny, The Harters). Their label debut, The House Rules, was released December 7, 2010. It debuted at #1 on the Billboard Heatseekers album chart and #25 on the Country Albums chart.^[12] The album was produced by Bob Ezrin and Jimmie Lee Sloas.^[13]

The first single from the album, also titled "The House Rules" debuted at #54 on the Billboard Country Songs chart^[14] and was the 7th most added song on Mediabase Country stations on its official impact date.^[13] The video for the single was directed by Timothy Hutton and premiered on CMT's Big New Music Weekend October 1, 2010.^[15] The second single, Let Me Go, was released on July 11, 2011. The video for the single was directed by Roman White, it premiered on CMT August 8, 2011 and reached #1 on their Today's Top Videos chart .^[16]

Christian Kane is also signed to a songwriting deal with EMI Music Publishing and writes much of his own material. Trace Adkins released a song written by Kane called "Happy Man" on his 2010 album, Cowboy's Back in Town.^[17]

Kane's co-writing efforts include songs written with Blair Daly, Brett James, David Lee Murphy, Casey Beathard, and Jerrod Niemann.^[18] "Thinking of You", a song he co-wrote with Blair Daly, featured in episode 3X06, "The Studio Job", of Leverage.^[4][19]

Filmography[link]

Actor[link]

Soundtrack[link]

Discography[link]

Studio albums[link]

Extended plays[link]

Live albums[link]

Singles[link]

Music videos[link]

References[link]

External links[link]

Wikimedia Commons has media related to: Christian Kane

• Official website
• Christian Kane Official Facebook
• Christian Kane Official Myspace
• Christian Kane Official Twitter
• Christian Kane at the Internet Movie Database