Interstate 10 (I-10) is the fourth-longest Interstate Highway in the United States, after I-90, I-80, and I-40. It is the southernmost east–west, coast-to-coast Interstate Highway (although I-4 and I-8 are further south). It stretches from the Pacific Ocean at State Route 1 (Pacific Coast Highway) in Santa Monica, California to Interstate 95 in Jacksonville, Florida. I-10 intersects with nine of the 10 primary north–south interstates (all except I-85) and also with the major Interstate routes I-8, I-12, I-17, I-19, I-20, I-37, I-49 and I-59.

Between its west terminus in Santa Monica, California and the East Los Angeles Interchange it is known as the Santa Monica Freeway. The Santa Monica Freeway is also called the "Rosa Parks Freeway" for the segment beginning at I-405 (the San Diego Freeway), and ending at I-110 / State Route 110 (the Harbor Freeway); either name can be used when referring to this stretch of road. The segment between the East Los Angeles Interchange and the city of San Bernardino, California, 63 miles (101 km) long, is known as the San Bernardino Freeway. Other names exist for I-10. For example, a sign near the western terminus of the highway (in Santa Monica, California) announces it as the Christopher Columbus Transcontinental Highway. It is known to a considerably lesser degree as the "Veterans Memorial Highway", and it is listed as a Blue Star Memorial Highway.