SPRED1

Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) is a protein that in humans is encoded by the SPRED1 gene located on chromosome 15q13.2 and has seven coding exons.

Function

Spred-1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade.

Clinical associations

Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).

Mutations in this gene are associated with

Mutations

The following mutations have been observed:

Chance (TV series)

Chance is an upcoming American television series created by Kem Nunn and Alexandra Cunningham starring Hugh Laurie. The series is based on the book by Nunn of the same name and has been ordered straight-to-series on January 06, 2016 with a straight two-season-order, containing 20 Episodes.

Plot

The series focuses on a San Francisco-based forensic neuropsychiatrist, played by Laurie.

Cast

References

Chance (novel)

Chance is a novel by Joseph Conrad, published in 1913 following serial publication the previous year. Although the novel was not one upon which Conrad's later critical reputation was to depend, it was his greatest commercial success upon initial publication.

Chance is narrated by Conrad's regular narrator, Charles Marlow, but is characterised by a complex, nested narrative in which different narrators take up the story at different points. The novel is also unusual among its author's works for its focus on a female character: the heroine, Flora de Barral.

The narrators describe and attempt to interpret various episodes in the life of Miss de Barral, the daughter of a convicted swindler named Smith de Barral (though this character is famous in the world of the novel as a criminal, he may, at least at first, have been merely an incompetent banker). Miss de Barral leads a sheltered life while her father is prosperous, then must rely on the generosity of others, who resent her or have agendas for her, before she escapes by marrying one Captain Anthony. Much of the book involves the musing of the various narrators over what she and the Captain expected from this union, and what they actually got from it. When her father is released from prison, he joins them on ship, and the book heads towards its denouement.

Handful of Rain

Handful of Rain is a heavy metal album by Savatage that was released in 1994. The first album since the death of their lead guitarist, Criss Oliva, the music is often dark in reflection of brother Jon Oliva's loss.

The title track was originally released as an abridged version, missing its second verse. Some editions of the album (for instance, the "Rock Masters" version released on the iTunes Store) include the omitted piece, referred to by the band and fans alike as "The Barmaid Verse". "Chance" is about Chiune Sugihara, a Japanese diplomat in Lithuania during World War II who defied government orders by signing exit visas for thousands of Jewish refugees. "Castles Burning" is about Giovanni Falcone, an Italian magistrate killed by the mafia in 1992. "Alone You Breathe" is a tribute to Criss which reuses the chord progression (albeit in a different key) and lyrics from the Streets song "Believe" in its long coda, and also part of the ending chorus in the Gutter Ballet song "When The Crowds Are Gone", although the lyrics do not mirror his death and the songs are not literally about him. The tour in support of this album was documented in the live release, Japan Live '94, which was released in 1995.

Jana Kramer

Jana Rae Kramer (born December 2, 1983) is an American actress and country music singer. She is best known for her role as Alex Dupre on the television series One Tree Hill. Kramer began a country music career in 2012 with the single "Why Ya Wanna" from her self-titled debut album for Elektra Records.

Early life

Kramer was born in Rochester Hills, Michigan, United States, to Nora and Martin Kramer. She is of German Chilean, Croatian and French ancestry. Jana has one brother Steve who is a police officer. Jana attended Rochester Adams High School. She speaks some German.

Career

2002–11: acting career and record deal

In 2002, Kramer made her acting debut in the low-budget independent horror film Dead/Undead. The following year Kramer guest appeared on All My Children, which marked Kramer's television debut. Kramer has since continued to appear in a number of television shows such as CSI: Crime Scene Investigation, Grey's Anatomy, Private Practice and CSI: NY. She has also had small supporting roles in films such as Click, Prom Night and Spring Breakdown.

Love (given name)

Love, or more uncommon Lowe, is a Swedish version of the French name Louis. It can also be a version of Lovisa, and can thus be used both for men and women, although it is more common with men.

The name is uncommon amongst adults; there are less than 200 men older than 30 in Sweden with the name, but several hundreds from every cohort born in the 1990s. 31 December 2009, there was in total 6,058 men in Sweden with the name Love/Lowe, of which 2,953 had it as first nnameame, the rest as middle name. There were also 531 women with the name, of which 128 had it as given name.

In 2003, 344 boys got the name, and of those, 182 got it as given name. The same year, 24 girls got the name, of which 6 got it as given name.

The name day in Sweden is 2 October (1986-1992: 3 December; 1993-2000: 26 November).

Persons with the name Love or Lowe

References

SCB

Tennis scoring system

A tennis tournament is organized into matches between players (for singles tournaments) or teams of two players (for doubles tournaments). The matches of a tournament are grouped into rounds. In round 1, all players (or teams) are paired and play against each other in matches. The losers are said to leave, or be out. They no longer compete in the tournament (this is single elimination). The winners are again paired to play in the matches of the next round. The tournament continues until the quarterfinal round (having eight players or teams playing in pairs), then the semifinal round (having four players or teams playing in pairs), and finally the final round (having only two players or teams) are played. The winner of the final round is declared the winner of the entire tournament.

A tennis match is composed of points, games, and sets. A match is won when a player or a doubles team wins the majority of prescribed sets. Traditionally, matches are either a best of three sets or best of five sets format. The best of five set format is typically only played in the Men's singles or doubles matches at Majors and Davis Cup matches.