Nicolás Andrés Burdisso (born 12 April 1981) is an Argentine professional footballer who plays as a central or right defender for A.S. Roma. He also holds European Union nationality.

Burdisso is the product of Argentine club Boca Juniors's youth system. He began his professional career with them in 1999 at age 18. With Boca Juniors, he won two Argentine Championships (2000 Apertura and 2003 Apertura), three Copa Libertadores (2000, 2001, 2003), and two Intercontinental Cups (2000, 2003).

In 2004, he moved to Internazionale, signing a four-year contract. However, he missed almost all of the 2004–05 season with Inter helping his daughter to fight leukemia. Returning to the squad in mid-2005, he won the 2006 Coppa Italia. On 31 August 2006, he extended his contract until 2009. During 2006, when Giacinto Facchetti died, Burdisso was given the number 16 jersey for the retirement of Facchetti's beloved number 3 jersey. In spite of being a defender, he has scored a number of goals, including two goals scored with headers on 29 November 2006 in the 4–0 victory against Messina. He again scored twice on 24 January 2007, in the 3–0 victory against Sampdoria. He has scored many goals from headers off of corner-kicks.