Karnei Shomron (Hebrew: קַרְנֵי שׁוֹמְרוֹן‎‎) (lit. "Rays of (light of) Samaria") is an Israeli settlement and town established in 1977 in the northwestern West Bank, east of Kfar Sava. Karnei Shomron is located 48 kilometres (30 mi) northeast of Tel Aviv and 85 kilometres (53 mi) north of Jerusalem. In 2006, the population of Karnei Shomron was 6,300. The international community considers Israeli settlements in the West Bank illegal under international law, but the Israeli government disputes this.

In 1991, several Israeli settlements were merged to become a single municipality called Karnei Shomron Local Council:

Mitzpe Tzvaim; Midreshet Shilat, a midrasha for girls; and Ramat Gil'ad are also part of Karnei Shomron. Neve Aliza is a religious neighborhood of American-style homes founded by new immigrants from the United States and Canada in 1985.

The chief rabbi of Karnei Shomron is Rabbi Yitzhak HaLevy. Herzl Ben-Ari is the head of the Karnei Shomron Local Council.

On February 16, 2002, two teenagers were killed and 30 people were wounded, six seriously, when a suicide bomber blew himself up at a pizzeria in the Karnei Shomron (located in Ginot Shomron) shopping mall. A third teenager died of her wounds on February 27. The Popular Front for the Liberation of Palestine claimed responsibility for the attack.