Multiple endocrine neoplasia type 2

Multiple endocrine neoplasia type 2 (MEN2) (also known as "Pheochromocytoma and amyloid producing medullary thyroid carcinoma", "PTC syndrome," and "Sipple syndrome") is a group of medical disorders associated with tumors of the endocrine system. The tumors may be benign or malignant (cancer). They generally occur in endocrine organs (e.g. thyroid, parathyroid, and adrenals), but may also occur in endocrine tissues of organs not classically thought of as endocrine.

MEN2 is a sub-type of MEN (multiple endocrine neoplasia) and itself has sub-types, as discussed below.

Classification

Before gene testing was available, the type and location of tumors determined which type of MEN2 a person had. Gene testing now allows a diagnosis before tumors or symptoms develop.

A table in the multiple endocrine neoplasia article compares the various MEN syndromes. MEN2 and MEN1 are distinct conditions, despite their similar names. MEN2 includes MEN2A, MEN2B and familial medullary thyroid cancer (FMTC).

Boyz II Men

Boyz II Men is an American R&B vocal group, best known for emotional ballads and a cappella harmonies. Formerly a quartet featuring Michael McCary, they are currently a trio composed of baritone Nathan Morris alongside tenors Wanya Morris and Shawn Stockman. During the 1990s, Boyz II Men found fame on Motown Records as a quartet. McCary left the group in 2003 due to health issues.

During the 1990s, Boyz II Men gained international success. This began with the release of the number one single "End of the Road" in 1992, which reached the top of charts worldwide. "End of the Road" would set a new record for longevity, staying at number one on the Billboard Hot 100 for thirteen weeks, breaking the decades-old record held by Elvis Presley. Boyz II Men proceeded to break this record with the subsequent releases of "I'll Make Love to You" and "One Sweet Day" (with Mariah Carey), which, at fourteen and sixteen weeks respectively, each set new records for the total number of weeks at number one. "I'll Make Love to You" also topped the charts in Australia (for four weeks) and garnered international success. As of 2015, "One Sweet Day" still holds the all-time record with sixteen weeks at the top of the Hot 100.

Lady Deathstrike

Lady Deathstrike (Yuriko Oyama), occasionally spelled "Deathstryke," is a fictional supervillain appearing in American comic books published by Marvel Comics. She is a foe of the X-Men, especially Wolverine.

Her father Lord Dark Wind created the adamantium-bonding process that was forced on Wolverine by Weapon X. A self-styled warrior, Lady Deathstrike hired the villain Spiral’s "body shoppe" to bond adamantium to her own skeleton in addition to other cyber-genetic enhancements. She has since worked as a mercenary and assassin and feels a need to prove herself by killing Wolverine.

A mutant version of Lady Deathstrike, played by Kelly Hu and without any of Deathstrike's backstory, appeared as a brainwashed henchwoman of William Stryker in the 2003 film X2: X-Men United. She also re-appeared in X-Men: The Official Game, where she was revealed to be Silver Samurai's apprentice. In 2009, Lady Deathstrike was ranked as IGN's 78th Greatest Comic Book Villain of All Time.

Publication history