"Mad" is a song by American pop/R&B singer Ne-Yo. It is the third single from his album Year of the Gentleman and was produced by Stargate and himself.
The video for the song was directed by Diane Martel. It premiered on AOL on November 25, 2008. The video, shot in black and white, presents a narrative wherein Ne-Yo argues with his girlfriend (played by Faune Chambers). After leaving, in an attempt to save a child from a car accident, someone is fatally hit. At the end of the video, it is revealed that the whole time it has been the ghost of Ne-Yo's character singing, and that it was he who was killed. The video to this song is Part 2 to his song Part of the List.
The music video appears to mirror the 1999 American thriller The Sixth Sense from M. Night Shyamalan, in which Bruce Willis plays a psychologist who is shot by an estranged patient of his. Based on how the film was shot and portrayed, Bruce Willis is shown in many situations as if he is there physically, when in actuality he was murdered by his patient, just as how Ne-Yo appears with his girlfriend, seeming to be there physically and that she is ignoring him due to their earlier argument, when he is actually dead.
Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons. The human orthologues of Mad2 (MAD2L1 and MAD2L2) were first cloned in a search for human cDNAs that would rescue the microtubule poison-sensitivity of a yeast strain in which a kinetochore binding protein was missing. The protein was shown to be present at unattached kinetochores and antibody inhibition studies demonstrated it was essential to execute a block in the metaphase-to-anaphase transition in response to the microtubule poison nocodazole. Subsequent cloning of the Xenopus laevis orthologue, facilitated by the sharing of the human sequence, allowed for the characterization of the mitotic checkpoint in egg extracts.
The first season of Veronica Mars, an American drama television series created by Rob Thomas, premiered on UPN in the United States on September 22, 2004. The series was produced by Warner Bros. Television, Silver Pictures Television and Rob Thomas Productions, and Joel Silver and Thomas served as the executive producers.
The season revolves around Veronica Mars (Kristen Bell), a high school student and private investigator in the fictional Southern California seaside town of Neptune. When Veronica's best friend, Lilly Kane (Amanda Seyfried), is murdered, her life falls apart. Her father, County Sheriff Keith Mars (Enrico Colantoni), accuses Lilly's father of being involved in the murder. This provokes Neptune's wrath and Keith's ousting as sheriff in a recall election. Veronica's mother, Lianne (Corinne Bohrer), develops a drinking problem and leaves town. Veronica's "09er" friends—wealthy students from the fictional 90909 ZIP code—force her to choose between them and her father; she chooses her father. Keith opens a private investigation agency, Mars Investigations, where Veronica works part-time.
George is a widespread given name, derived from Greek Γεώργιος (Geōrgios)) through the Latin Georgius. While it is commonly a masculine name, in English it is also sometimes given as a feminine name. Its popularity is due to the widespread veneration of the Christian military saint Saint George (George of Lydda c. 275/281–303).
The name derives in origin from the name of Zeus Georgos, worshipped as a god of crops.
The noun γεωργός geōrgos "husbandman, farmer" and the verb γεωργέω geōrgeō "to be a farmer; to plow, till, cultivate" is found in the classical language (Plato, Aristophanes). The word geōrgos "husbandman, farmer" was one of Zeus's epithets in Athens: Ζεύς Γεωργός (Zeus Geōrgos), the god of crops and harvest.Aelius Herodianus in the 2nd century lists Georgios alongside Demetrios and Ammonios as a theophoric name derived from the theonym by suffixing -ios. It is likely that the historical Saint George (Georgios) was born in Lydda, Palestine in c. 280 as the son of a Greek Christian nobleman from Cappadocia. After his martyrdom in 303, the name Georgios soon became used more widely among Christians in the Eastern Empire.
George, Giorgi, (Georgian: გიორგი) (1250–1268) was the eldest son of David VII Ulu, a Bagratid king of Georgia, by whom he was designated as heir-apparent to the throne. In the early 1260s, he was held as a hostage at the Mongol Ilkhan court of Hulagu Khan and later served with his father in the Mongol military ranks. He died at the age of 18 in 1268, preceding his father by two years.
George was born in 1250 to King David VII and the Alan woman Altun, whom the king took as a temporary wife because he had no children by his queen Jigda-Khatun and whom he agreed to dismiss after the birth of an heir. The marriage was, in fact, repudiated after the birth of the second child, a daughter, Tamar. George was adopted by Jigda-Khatun, who died shortly afterwards. George, along with his father, step-mother, and the uncle David VI Narin, is mentioned in a church inscription from Abelia in the south of Georgia.
George is a webcomic written and illustrated by John R. Norton. The strip has been in existence for several years, making its first appearance on the web as early as 1999. As of December 4, 2009, there have been 529 full-color comics published. The current George website was established in January 2005, using a strip from the old site to make its debut. Since then, however, all content has been entirely new. New comic strips were originally posted every Monday and Thursday before going to a Monday-Wednesday-Friday schedule. In early 2006, the strip went on hiatus for most of the year, but returned with regular, though unscheduled, updates in January 2007. Currently, new comics are once again posted on Mondays, Wednesdays and Fridays.
The strip is centered around a fairly normal freelance cartoonist, George, and his circle of friends. The strip often deals with computers, technology, and generally "geeky" things like World of Warcraft and Star Wars, though a myriad of light-hearted subjects are commonly explored. The strip takes place in the fairly small, fictional town of Perkton, located in the heart of California, presumably somewhere near Fresno. It is not particularly close to well-known California cities such as Los Angeles and San Francisco, and is not in line with the stereotypical view of California. Most of the strip's characters are between 26 and 30 years of age, with a few exceptions, such as Chain-Link Jefferson and Coach Demurson, who are much older, and Megan Beauxmont, who is much younger.