Wleń

Wleń [vlɛɲ] (German: Lähn) is a town in Lwówek Śląski County, Lower Silesian Voivodeship, in south-western Poland. It is located on the Bóbr river in the historic Lower Silesian region, approximately 13 kilometres (8 mi) south-east of Lwówek Śląski, and 97 kilometres (60 mi) west of the regional capital Wrocław.

The town is the seat of the administrative district (gmina) called Gmina Wleń. As of 2011, it has a population of 1,855.

Wleń was established in 1214 by the Silesian duke Henry I the Bearded and his wife Hedwig of Andechs. The ruins of Łupki Castle (German: Lehnhaus), until 1945 property of the Haugwitz noble family, lie off the town's center, it served to protect the nearby borders with Bohemia and Upper Lusatia and was devastated during the Thirty Years' War. A Baroque palace was rebuilt underneath it. Prior to 1945 it was in Germany. After World War II the region was placed under Polish administration and ethnically cleansed according to the post-war Potsdam Agreement. The native German populace was expelled and replaced with Poles.

Wheeling and Lake Erie Railway (1916–88)

The Wheeling and Lake Erie Railway (reporting mark WLE) was a Class I railroad mostly within the U.S. state of Ohio. It was leased to the New York, Chicago and St. Louis Railroad (Nickel Plate Road) in 1949, and merged into the Norfolk and Western Railway in 1988. A new regional railroad reused the Wheeling and Lake Erie Railway name in 1990 when it acquired most of the former W&LE from the N&W.

At the end of 1944, W&LE operated 507 miles of road and 1003 miles of track; that year it reported 2371 million net ton-miles of revenue freight and 0.002 million passenger-miles.

History

The original Wheeling and Lake Erie Railway's oldest predecessor rail line began in Ohio, with the organization of the Carroll County Railroad on March 9, 1850.

The Wheeling and Lake Erie Railroad was established on April 6, 1871, and was first built as a 3 ft (914 mm) gauge narrow gauge line between Norwalk and Huron, Ohio. Service began on the new line on May 31, 1877. However, the new road was unable to attract regular traffic, or financing for expansion, and had closed within two years.

Wingless localisation element 3 (WLE3)

The WL3 Wingless localisation element 3 (WLE3) is an RNA structure that localises the wingless mRNA in flies.

The structure consists of a stem, a bulge region, another stem and a loop. The published structure was determined and refined through experiments.

Wingless localisation element 3 (WLE3) is a 53-nt (nt 518-570) apical localization element within the 3'-untranslated region of the wingless (wg) mRNA. It is shown to be sufficient and necessary for apical RNA transport in microinjection assays and transgenic reporters. Indeed, deletion of WLE3 in an otherwise full-length wg 3'UTR completely abolishes apical localization. However, a minimal WLE3 monomer by itself shows weak activity on its own. The incomplete activity of a single WLE3 element indicates a requirement for additional elements or sequences.

Phylogenetic comparison of WLE3 elements predicts a highly conserved stem-loop structure in Drosophila species (using ALIFOLD) and deemed necessary for WLE function by mutational analyses.