Zacapa is one of the 22 departments of Guatemala. The capital is the city of Zacapa.

Coordinates: 14°58′21″N 89°31′42″W / 14.9725°N 89.52833°W / 14.9725; -89.52833

Zacapa is a city in eastern Guatemala, along the Río Grande de Zacapa. It is renowned locally for its manual crafting of cigars, hard dry cheese and a flavored cake made with said cheese (Quezadilla).

Zacapa once was a bustling railroad stop and attracted a fair number of non-Guatemalan immigrants, it is not unusual to find people whose surnames were originally from England, Germany, Italy, and Spain.

Zacapa is also the name of the departmental capital department of Zacapa and the municipal seat of Zacapa municipality. The population for the whole department of Zacapa as of the year 2000 is estimated at 212,794, 94.09% are non-indigenous (mostly of European ancestry or Mestizos), only about 4.39% are Indigenous.

Other cities close to Zacapa (in the same department of Zacapa) are Gualan (once a river port), Teculutan (located on the Carretera al Atlantico providing stopover facilities) and Estanzuela, home to the Calado handicrafts and to the Archeological Museum.

Zacapa is mainly a rural area that contains a large amount of flat land used mostly to grow cantaloupe, tobacco and roma tomatoes. Bordering the Zacapa valley is the Sierra de las Minas, which harbors forests, and contains marble mines and coffee plantations. Some of the world's finest jade is also found in this area.