3-dehydrosphinganine reductase
3-dehydrosphinganine reductase (EC 1.1.1.102) also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an enzyme that in humans is encoded by the KDSR gene.
Function
3-dehydrosphinganine reductase catalyzes the chemical reaction:
Thus, the two substrates of this enzyme are sphinganine and NADP+, whereas its 3 products are 3-dehydrosphinganine, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in sphingolipid metabolism.
Tissue distribution
Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue.
Clinical significance
FVT1 shows a high rate of transcription in some T cell malignancies and in phytohemagglutinin-stimulated lymphocytes. The proximity of FVT1 to BCL2 suggests that it may participate in the tumoral process.
References
FVT
FVT may refer to:
X-Ray Mirror
Tunnel seems so long
Touching the bottom
A slim reflexion
Punctured my vision
I didn't notice
Beside the last door
Standing on nothing
There was a mirror
Even inside... scrutinized
I am, he is, the face I hate
Refracting cells and prismed self
Who's X who's y in a blank place
I can't believe this is my image
Like the mirror without a frame
Baring a scarred side
Open in daylight
Recoil and reply
Farside of my pride
The introspection
Ruptures the blood core
Magnification
Draws out the mirror
Seeking me out
What will he find?
I am, he is, a repugnant state
I can't shake this curiosity
My privacy starts to fade
I can't believe this is my image
Like the mirror
A polar exchange
He gloating over my fleeting image
He used to be me
He knows who is free
How long will I wait... here
Stuck in this void place... here
I can't believe I am the immage
Within the mirror
Into the chrome lake
The glass is broken
